Publication: The effect of centrally injected CDP-choline on respiratory system; involvement of phospholipase to thromboxane signaling pathway
Date
Authors
Topuz, Bora Burak
Altınbaş, Burçin
Yılmaz, Mustafa Sertaç
Savcı, Vahide
Yalçın, Murat
Authors
Saha, Sikha
Batten, Trevor F.C.
Advisor
Language
Type
Publisher:
Elsevier
Journal Title
Journal ISSN
Volume Title
Abstract
CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Exogenous administration of CDP-choline has been shown to affect brain metabolism and to exhibit cardiovascular, neuroendocrine neuroprotective actions. On the other hand, little is known regarding its respiratory actions and/or central mechanism of its respiratory effect. Therefore the current study was designed to investigate the possible effects of centrally injected CDP-choline on respiratory system and the mediation of the central cholinergic receptors and phospholipase to thromboxane signaling pathway on CDP-choline-induced respiratory effects in anaesthetized rats. Intracerebroventricularly (i.c.v.) administration of CDP-choline induced dose- and time-dependent increased respiratory rates, tidal volume and minute ventilation of male anaesthetized Sprague Dawley rats. I.c.v. pretreatment with atropine failed to alter the hyperventilation responses to CDPcholine whereas mecamylamine, cholinergic nicotinic receptor antagonist, mepacrine, phospholipase A2 inhibitor, and neomycin phospholipase C inhibitor, blocked completely the hyperventilation induced by CDP-choline. In addition, central pretreatment with furegrelate, thromboxane A2 synthesis inhibitor, also partially blocked CDP-choline-evoked hyperventilation effects. These data show that centrally administered CDP-choline induces hyperventilation which is mediated by activation of central nicotinic receptors and phospholipase to thromboxane signaling pathway.
Description
Source:
Keywords:
Keywords
CDP-choline, Tidal volume, Central cholinergic receptors, Respiratory frequency, Central prostaglandinergic system, Minute ventilation, Intracerebroventricular, Increases plasma vasopressin, Arachidonic-acid, Cytidine, Brain, Hypotension, Rat, Activation, Pressor, Receptor, A(2), Physiology, Respiratory system
Citation
Topuz, B. B. vd. (2014). "The effect of centrally injected CDP-choline on respiratory system; involvement of phospholipase to thromboxane signaling pathway". Respiratory Physiology and Neurobiology, 195, 50-58.