Publication: The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids
dc.contributor.author | Ceylan, Alper | |
dc.contributor.author | Kara, Nurten | |
dc.contributor.author | Güven, Hakan | |
dc.contributor.author | Yıldız, Levent | |
dc.contributor.buuauthor | Kaya, Ekrem | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Cerrahi Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-9562-4195 | |
dc.contributor.researcherid | AAG-7319-2021 | |
dc.contributor.scopusid | 7004568109 | |
dc.date.accessioned | 2024-03-14T07:54:08Z | |
dc.date.available | 2024-03-14T07:54:08Z | |
dc.date.issued | 2007-06 | |
dc.description.abstract | Background/aims: The effects of short-chain fatty acids and glutamine on diseased colonic mucosa, such as in inflammatory bowel disease, are not well described. The aim of this study was to investigate the role of L-glutamine and short-chain fatty acids, both via enema and oral administration, on mucosal healing in experimental colitis. Methods: Colitis was induced with trinitrobenzenesulphonic acid in ethanol enema in rats. Saline enema (Colitis group, n: 12), L-glutamine enema (n: 12), short-chain fatty acids enema (n: 12), oral L-glutamine (n:11) and oral short-chain fatty acids (n. 11) were applied twice daily for 10 days after induction of colitis. The sham group (n: 12) received only saline enema. Rats were sacrificed at the tenth day. Crypt depth and DNA content were measured in colonic mucosa. Results: Crypt depth was significantly greater in both glutamine groups and short-chain fatty acids enema group than in sham and colitis groups (p<0.05). The mucosal DNA contents of the colitis and glutamine enema groups were significantly greater than both short-chain fatty acids groups (p<0.05). DNA content in the oral glutamine group was significantly greater than in the short-chain fatty acids enema group (p<0.05). Conclusions: L-glutamine enema can accelerate mucosal healing and regeneration in experimentally induced colitis in rats. When compared to glutamine in this study, short-chain fatty acids showed no beneficial effect on colitis. | |
dc.identifier.citation | Kaya, L. vd. (2007). "The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids". Turkish Journal of Gastroenterology, 18(2), 89-94. | |
dc.identifier.endpage | 94 | |
dc.identifier.issn | 1300-4948 | |
dc.identifier.issue | 2 | |
dc.identifier.pubmed | 17602355 | |
dc.identifier.scopus | 2-s2.0-43549126223 | |
dc.identifier.startpage | 88 | |
dc.identifier.uri | https://hdl.handle.net/11452/40391 | |
dc.identifier.volume | 18 | |
dc.identifier.wos | 000254609800005 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Aves | |
dc.relation.collaboration | Yurt içi | |
dc.relation.journal | Turkish Journal of Gastroenterology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Experimental colitis | |
dc.subject | Glutamine | |
dc.subject | Short-chain fatty acid | |
dc.subject | Gastroenterology & hepatology | |
dc.subject | Absorption | |
dc.subject | Enemas | |
dc.subject | Rat | |
dc.subject | Distal colon | |
dc.subject | Rectal irrigation | |
dc.subject | Experimental-model | |
dc.subject | Cell proliferation | |
dc.subject | Butyrate metabolism | |
dc.subject | Colonic-mucosa | |
dc.subject | Quiescent ulcerative-colitis | |
dc.subject.emtree | Alcohol | |
dc.subject.emtree | Butyric acid | |
dc.subject.emtree | Dna | |
dc.subject.emtree | Enema | |
dc.subject.emtree | Glutamine | |
dc.subject.emtree | Short chain fatty acid | |
dc.subject.emtree | Sodium chloride | |
dc.subject.emtree | Trinitrobenzenesulfonic acid animal experiment | |
dc.subject.emtree | Animal model | |
dc.subject.emtree | Animal tissue | |
dc.subject.emtree | Article | |
dc.subject.emtree | Colitis | |
dc.subject.emtree | Colon mucosa | |
dc.subject.emtree | Controlled study | |
dc.subject.emtree | Diarrhea | |
dc.subject.emtree | Dna content | |
dc.subject.emtree | Experimental study | |
dc.subject.emtree | Histopathology | |
dc.subject.emtree | Inflammation | |
dc.subject.emtree | Nonhuman | |
dc.subject.emtree | Rat | |
dc.subject.emtree | Weight change | |
dc.subject.emtree | Wound healing | |
dc.subject.mesh | Administration, oral | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Colitis | |
dc.subject.mesh | Disease models, animal | |
dc.subject.mesh | Dna | |
dc.subject.mesh | Enema | |
dc.subject.mesh | Glutamine | |
dc.subject.mesh | Intestinal mucosa | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, wistar | |
dc.subject.mesh | Regeneration | |
dc.subject.mesh | Wound healing | |
dc.subject.scopus | Volatile Fatty Acid; Butyric Acid; Intestine Flora | |
dc.subject.wos | Gastroenterology & hepatology | |
dc.title | The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Cerrahi Ana Bilim Dalı | |
local.indexed.at | WOS | |
local.indexed.at | Scopus |
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