Publication:
The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids

dc.contributor.authorCeylan, Alper
dc.contributor.authorKara, Nurten
dc.contributor.authorGüven, Hakan
dc.contributor.authorYıldız, Levent
dc.contributor.buuauthorKaya, Ekrem
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentCerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0002-9562-4195
dc.contributor.researcheridAAG-7319-2021
dc.contributor.scopusid7004568109
dc.date.accessioned2024-03-14T07:54:08Z
dc.date.available2024-03-14T07:54:08Z
dc.date.issued2007-06
dc.description.abstractBackground/aims: The effects of short-chain fatty acids and glutamine on diseased colonic mucosa, such as in inflammatory bowel disease, are not well described. The aim of this study was to investigate the role of L-glutamine and short-chain fatty acids, both via enema and oral administration, on mucosal healing in experimental colitis. Methods: Colitis was induced with trinitrobenzenesulphonic acid in ethanol enema in rats. Saline enema (Colitis group, n: 12), L-glutamine enema (n: 12), short-chain fatty acids enema (n: 12), oral L-glutamine (n:11) and oral short-chain fatty acids (n. 11) were applied twice daily for 10 days after induction of colitis. The sham group (n: 12) received only saline enema. Rats were sacrificed at the tenth day. Crypt depth and DNA content were measured in colonic mucosa. Results: Crypt depth was significantly greater in both glutamine groups and short-chain fatty acids enema group than in sham and colitis groups (p<0.05). The mucosal DNA contents of the colitis and glutamine enema groups were significantly greater than both short-chain fatty acids groups (p<0.05). DNA content in the oral glutamine group was significantly greater than in the short-chain fatty acids enema group (p<0.05). Conclusions: L-glutamine enema can accelerate mucosal healing and regeneration in experimentally induced colitis in rats. When compared to glutamine in this study, short-chain fatty acids showed no beneficial effect on colitis.
dc.identifier.citationKaya, L. vd. (2007). "The effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids". Turkish Journal of Gastroenterology, 18(2), 89-94.
dc.identifier.endpage94
dc.identifier.issn1300-4948
dc.identifier.issue2
dc.identifier.pubmed17602355
dc.identifier.scopus2-s2.0-43549126223
dc.identifier.startpage88
dc.identifier.urihttps://hdl.handle.net/11452/40391
dc.identifier.volume18
dc.identifier.wos000254609800005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAves
dc.relation.collaborationYurt içi
dc.relation.journalTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExperimental colitis
dc.subjectGlutamine
dc.subjectShort-chain fatty acid
dc.subjectGastroenterology & hepatology
dc.subjectAbsorption
dc.subjectEnemas
dc.subjectRat
dc.subjectDistal colon
dc.subjectRectal irrigation
dc.subjectExperimental-model
dc.subjectCell proliferation
dc.subjectButyrate metabolism
dc.subjectColonic-mucosa
dc.subjectQuiescent ulcerative-colitis
dc.subject.emtreeAlcohol
dc.subject.emtreeButyric acid
dc.subject.emtreeDna
dc.subject.emtreeEnema
dc.subject.emtreeGlutamine
dc.subject.emtreeShort chain fatty acid
dc.subject.emtreeSodium chloride
dc.subject.emtreeTrinitrobenzenesulfonic acid animal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeColitis
dc.subject.emtreeColon mucosa
dc.subject.emtreeControlled study
dc.subject.emtreeDiarrhea
dc.subject.emtreeDna content
dc.subject.emtreeExperimental study
dc.subject.emtreeHistopathology
dc.subject.emtreeInflammation
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeWeight change
dc.subject.emtreeWound healing
dc.subject.meshAdministration, oral
dc.subject.meshAnimals
dc.subject.meshColitis
dc.subject.meshDisease models, animal
dc.subject.meshDna
dc.subject.meshEnema
dc.subject.meshGlutamine
dc.subject.meshIntestinal mucosa
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshRegeneration
dc.subject.meshWound healing
dc.subject.scopusVolatile Fatty Acid; Butyric Acid; Intestine Flora
dc.subject.wosGastroenterology & hepatology
dc.titleThe effect of L-glutamine on mucosal healing in experimental colitis is superior to short-chain fatty acids
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Cerrahi Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: