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Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines

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dc.contributor.authorCevatemre, Buse
dc.contributor.authorAygun, Muhittin
dc.contributor.authorUlukaya, Engin
dc.contributor.buuauthorİçsel, Ceyda
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentKimya, Anorganik Kimya Bölümü
dc.contributor.orcid0000-0002-2849-3332
dc.contributor.orcid0000-0002-2717-2430
dc.contributor.researcheridL-7238-2018
dc.contributor.researcheridAAI-3342-2021
dc.contributor.scopusid55551960400
dc.contributor.scopusid56441123900
dc.date.accessioned2023-04-14T12:25:01Z
dc.date.available2023-04-14T12:25:01Z
dc.date.issued2019-06
dc.description.abstractCis-[PtCl(sac)(PPh2Me)(2)] (1), cis-[PtCl(sac)(PPhMe2)(2)] (2), trans-[PtCl(sac)(PPh2Et)(2)] (3) and trans- [PtCl(sac) (PPhEt2)(2)] (4) complexes (sac = saccharinate) were synthesized and characterized by elemental analysis and spectroscopic methods. The structures of 2-4 were determined by X-ray single-crystal diffraction. The interaction of the complexes with DNA was studied various biochemical, biophysical and molecular docking methods. Only the cis-configured complexes (1 and 2) showed nuclease activity and their binding affinity towards DNA was considerably higher than those of their trans-congeners (3 and 4). The chlorido ligand in the cis-configured complexes underwent aquation, making them more reactive towards DNA. Furthermore, 1 and 2 exhibited anticancer potency on breast (MCF-7) and colon (HCT116) cancer cells similar to cisplatin, whereas 3 and 4 were biologicallly inactive. Mechanistic studies on MCF-7 cells showed that higher nuclear uptake, cell cycle arrest at the S phase, dramatically increased DNA double-strand breaks, apoptosis induction, elevated levels of reactive oxygen species (ROS) and high mitochondrial membrane depolarization greatly contribute to the anticancer potency of 1 and 2.
dc.identifier.citationİçsel, C. vd. (2019). ''Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines''. Journal of Inorganic Biochemistry, 195, 39-50.
dc.identifier.endpage50
dc.identifier.issn0162-0134
dc.identifier.issn1873-3344
dc.identifier.pubmed30889415
dc.identifier.scopus2-s2.0-85062936854
dc.identifier.startpage39
dc.identifier.urihttps://doi.org/10.1016/j.jinorgbio.2019.03.008
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0162013419300650
dc.identifier.urihttp://hdl.handle.net/11452/32399
dc.identifier.volume195
dc.identifier.wos000469408500005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.journalJournal of Inorganic Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak215Z230
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPt(II) complex
dc.subjectSaccharinate
dc.subjectPhosphine
dc.subjectDNA binding
dc.subjectCytotoxicity
dc.subjectAnticancer mechanism
dc.subjectAscites-carcinoma eac
dc.subjectAntiproliferative activity
dc.subjectPhosphorus Ligands
dc.subjectAntitumor-activity
dc.subjectPhosphine-Ligands
dc.subjectIn-Vitro
dc.subjectPalladium(II)
dc.subjectDNA
dc.subjectCislatin
dc.subjectTerpyridine
dc.subjectBiochemistry & molecular biology
dc.subjectChemistry
dc.subject.emtreeCisplatin
dc.subject.emtreeNuclease
dc.subject.emtreePhosphine derivative
dc.subject.emtreePlatinum complex
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCoordination compound
dc.subject.emtreeDNA
dc.subject.emtreePhosphine derivative
dc.subject.emtreePlatinum
dc.subject.emtreeSaccharin
dc.subject.emtreeAntineoplastic activity
dc.subject.emtreeArticle
dc.subject.emtreeBinding affinity
dc.subject.emtreeCancer cell
dc.subject.emtreeControlled study
dc.subject.emtreeDiffraction
dc.subject.emtreeDNA strand breakage
dc.subject.emtreeDrug DNA interaction
dc.subject.emtreeDrug mechanism
dc.subject.emtreeDrug potency
dc.subject.emtreeDrug structure
dc.subject.emtreeDrug synthesis
dc.subject.emtreeElemental analysis
dc.subject.emtreeHCT 116 cell line
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeLipophilicity
dc.subject.emtreeMCF-7 cell line
dc.subject.emtreeMembrane depolarization
dc.subject.emtreeMitochondrial membrane
dc.subject.emtreeMolecular docking
dc.subject.emtreeMxidative stress
dc.subject.emtreeS phase cell cycle checkpoint
dc.subject.emtreeX ray crystallography
dc.subject.emtreeApoptosis
dc.subject.emtreeChemical structure
dc.subject.emtreeChemistry
dc.subject.emtreeDouble stranded DNA break
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug screening
dc.subject.emtreeMetabolism
dc.subject.emtreeMitochondrion
dc.subject.emtreeSynthesis
dc.subject.emtreeTumor cell line
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshCell line, tumor
dc.subject.meshCoordination complexes
dc.subject.meshDNA
dc.subject.meshDNA breaks, double-stranded
dc.subject.meshDrug screening assays, antitumor
dc.subject.meshHumans
dc.subject.meshMitochondria
dc.subject.meshMoleculardocking simulation
dc.subject.meshMolecular structure
dc.subject.meshOxidative stress
dc.subject.meshPhosphines
dc.subject.meshPlatinum
dc.subject.meshS phase cell cycle checkpoints
dc.subject.meshSaccharin
dc.subject.scopusComplex; Palladium; 2-Phenylpyridine
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosChemistry, inorganic & nuclear
dc.titleStructures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines
dc.typeArticle
dc.wos.quartileQ2 (Biochemistry & molecular biology)
dc.wos.quartileQ1 (Chemistry, inorganic & nuclear)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya, Anorganik Kimya Bölümü
local.indexed.atScopus
local.indexed.atWOS

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