Publication:
MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats

dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorKorfali, Ender
dc.contributor.buuauthorÖztürk, Hülya
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.buuauthorYılmazlar, Selçuk
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.departmentBeyin Cerrahisi Ana Bilim Dalı
dc.contributor.orcid0000-0003-3633-7919
dc.contributor.orcid0000-0003-0841-8201
dc.contributor.researcheridAAH-5070-2021
dc.contributor.researcheridAAG-7070-2021
dc.date.accessioned2021-09-01T12:22:02Z
dc.date.available2021-09-01T12:22:02Z
dc.date.issued2005
dc.description.abstractBackground: Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of ischemic spinal cord injury (ISCI). The aim of this study was to investigate the neuroprotective effect of a single dose of MK-801, an antiexcitotoxic drug, in a rat model of ISCI. Methods: Ischemic spinal cord injury was induced for 17 minutes in Sprague-Dawley rats using direct aortic arch, just proximal to the left common carotid artery, plus left subclavian artery cross-clamping through a left-sided limited thoracotomy. Study groups were as follows: control group (n = 8) receiving only vehicle and experimental group (n = 8) receiving a single dose of MK-801 (1 mg/kg IV) 10 minutes before aortic clamping. Neurological examination was performed at 6 hours, 24 hours, and daily up to 96 hours. Rats were sacrificed at 96 hours, and spinal cords were removed for histopathology. Results: All the control rats had severe permanent neurological deficits after ISCI, whereas the MK-801-treated rats had statistically (P <.05) better neurological outcome and good recovery. Histopathology revealed severe neuronal necrosis in the lumbar gray matter of control rats, whereas MK-801-treated rats showed mild injury. Conclusion: These results demonstrate that combined temporary clipping of the aortic arch (just proximal to the left common carotid artery) plus left subclavian artery for 17 minutes reproduces reliable paraplegia, and a single dose of MK-801 given before ISCI provides significant neuroprotection.
dc.identifier.citationKocaeli, H. vd. (2005). "MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats". Surgical Neurology, 64(Supplement 2), 22-27.
dc.identifier.endpage27
dc.identifier.issn0090-3019
dc.identifier.issueSupplement 2
dc.identifier.scopus2-s2.0-27444443134
dc.identifier.startpage22
dc.identifier.urihttps://doi.org/10.1016/j.surneu.2005.07.034
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S009030190500532X
dc.identifier.urihttp://hdl.handle.net/11452/21620
dc.identifier.volume64
dc.identifier.wos000233321000006
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science
dc.relation.journalSurgical Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAorta
dc.subjectMK-801
dc.subjectNeuroprotection
dc.subjectRat
dc.subjectSpinal cord ischemia
dc.subjectThoracotomy
dc.subjectGlutamate antagonist
dc.subjectApoptosis
dc.subjectModel
dc.subjectInjury
dc.subjectParaplegia
dc.subjectPrevention
dc.subjectDeficits
dc.subjectNeurosciences & neurology
dc.subjectSurgery
dc.subject.scopusThoracic Aorta Aneurysm; Spinal Cord Ischemia; Endoleak
dc.subject.wosClinical neurology
dc.subject.wosSurgery
dc.titleMK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats
dc.typeArticle
dc.wos.quartileQ2 (Surgery)
dc.wos.quartileQ3 (Clinical neurology)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Beyin Cerrahisi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: