Publication:
Age-related changes in the rat hippocampus

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dc.contributor.authorİş, Merih
dc.contributor.authorComunoğlu, Cem
dc.contributor.authorEkici, Işın Doğan
dc.contributor.authorÖzkan, Ferda
dc.contributor.authorComunoğlu, Nil
dc.contributor.buuauthorEren, Bülent
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAdli Tıp Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-2319-1757
dc.contributor.researcheridAAU-7408-2020
dc.contributor.researcheridAAK-8096-2021
dc.contributor.researcheridAAX-8590-2021
dc.contributor.scopusid8725969000
dc.date.accessioned2022-03-16T13:25:50Z
dc.date.available2022-03-16T13:25:50Z
dc.date.issued2008-05
dc.description.abstractThe human brain is uniquely powerful in its cognitive abilities, yet the hippocampal and neocortical circuits that mediate these complex functions are highly vulnerable during aging. In this study, we analyzed age-related changes in the rat hippocampus by studying newborn (1 month), middle-aged (12 months), and older (24 months) male and female Sprague-Dawley rats. We evaluated neuronal dystrophy, neuron scattering, and granulovacuolar degeneration in the hippocampal area using light microscopy, according to age and gender. We detected significant neuronal dystrophy in the CA1, CA2, and CA3 areas in male rats, and in the CA1, CA3, and CA4 areas in female rats. Degenerative changes, indicated by neuron scattering, were observed in the CA1, CA2, and CA3 areas of male and the CA2 and CA4 areas of female rats. Changes in all areas of the hippocampus were observed with increasing age; these changes included neuronal dystrophy and neuron scattering and did not differ significantly between male and female rats.
dc.identifier.citationİş, M. vd. (2008). "Age-related changes in the rat hippocampus". Journal of Clinical Neuroscience, 15(5), 568-574.
dc.identifier.endpage574
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue5
dc.identifier.pubmed18342510
dc.identifier.scopus2-s2.0-41549141204
dc.identifier.startpage568
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2007.03.025
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0967586807003062
dc.identifier.urihttp://hdl.handle.net/11452/25101
dc.identifier.volume15
dc.identifier.wos000255339000014
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalJournal of Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectAging
dc.subjectGranulovacuolar degeneration
dc.subjectHippocampus
dc.subjectNeuron scattering
dc.subjectNeuronal dystrophy
dc.subjectGranulovacuolar degeneration
dc.subjectAlzheimers-disease
dc.subjectBrain
dc.subjectImpairment
dc.subjectNeurons
dc.subjectNumber
dc.subject.emtreeAging
dc.subject.emtreeAge
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeCell damage
dc.subject.emtreeCell degeneration
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeGender
dc.subject.emtreeGranulovacuolar degeneration
dc.subject.emtreeHippocampus
dc.subject.emtreeMale
dc.subject.emtreeMicroscopy
dc.subject.emtreeNeuron scattering
dc.subject.emtreeNeuronal dystrophy
dc.subject.emtreeNewborn
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.meshAge factors
dc.subject.meshAging
dc.subject.meshAmyloid beta-protein precursor
dc.subject.meshAnimals
dc.subject.meshFemale
dc.subject.meshHippocampus
dc.subject.meshMale
dc.subject.meshNerve degeneration
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley
dc.subject.meshSex factors
dc.subject.meshNeurons
dc.subject.scopusNeurofibrillary Tangles; Degeneration; Lewy Bodies
dc.subject.wosClinical neurology
dc.subject.wosNeurosciences
dc.titleAge-related changes in the rat hippocampus
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Adli Tıp Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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