Publication:
Effects of combination therapy with captopril and angiotensin ii on the viability of random-pattern skin flaps in diabetic rat model

dc.contributor.buuauthorAtalay, Fatma Öz
dc.contributor.buuauthorÖZ ATALAY, FATMA
dc.contributor.buuauthorVuruşkan, Berna Aytaç
dc.contributor.buuauthorAYTAÇ VURUŞKAN, BERNA
dc.contributor.buuauthorAkın, Selçuk
dc.contributor.buuauthorAKIN, SELÇUK
dc.contributor.buuauthorAygören, Binevs Heja
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-7188-6115
dc.contributor.researcheridAAH-9746-2021
dc.date.accessioned2024-09-24T06:16:47Z
dc.date.available2024-09-24T06:16:47Z
dc.date.issued2016-12-01
dc.description.abstractObjective: Diabetes mellitus leads to tissue damage by erythrocyte aggregation and an endothelial dysfunction-mediated disturbance in vascularization. These mechanisms facilitate the formation of skin wounds. As skin flaps are often used in the treatment of diabetic wounds, enhancing the blood supply and lowering blood glucose levels have emerged as important factors to increase the success of treatment using skin flaps. Therefore, in this study, the effectiveness of captopril and angiotensin II treatments were investigated to determine if they increased blood flow to skin flaps to protect their viability in an experimental diabetic rat model.Material and Methods: The experiment was conducted using 45 rats. Nine constituted the sham group, whereas diabetes was induced in 36 of them by an intraperitoneal injection of streptozotocin. Skin flaps (3x8 cm in diameter) were prepared, separated, and consequently reimplanted with staplers to their original place at the dorsum of the rats. Diabetic rats were treated with saline (n=9), angiotensin II (n=9), captopril (n=9), captopril+angiotensin II (n=9) during the postoperative period. Flap viability was assessed by clinical and histopathological findings.Results: The percentage of flap viability in diabetic rats was found to be significantly higher in the captopril+angiotensin II group than in the captopril group and was lowest in the angiotensin II group. Additionally, both individual and combined use of captopril and angiotensin II were found to increase the intensity of blood vessels compared to the administration of saline alone in diabetic rats.Conclusion: Our study showed that the use of captopril and angiotensin II could increase the viability of skin flaps in diabetic rats.
dc.identifier.doi10.5152/TurkJPlastSurg.2016.2077
dc.identifier.endpage196
dc.identifier.issn2528-8644
dc.identifier.issue4
dc.identifier.startpage190
dc.identifier.urihttps://doi.org/10.5152/TurkJPlastSurg.2016.2077
dc.identifier.urihttps://hdl.handle.net/11452/45104
dc.identifier.volume24
dc.identifier.wos000413899300006
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalTurkish Journal Of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndothelial growth-factor
dc.subjectIschemia-reperfusion
dc.subjectStimulates angiogenesis
dc.subjectType-1 receptor
dc.subjectBlood-flow
dc.subjectInhibition
dc.subjectSurvival
dc.subjectMuscle
dc.subjectInjury
dc.subjectPrevents
dc.subjectAngiotensin ii
dc.subjectCaptopril
dc.subjectDiabetes mellitus
dc.subjectSkin flap
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectSurgery
dc.titleEffects of combination therapy with captopril and angiotensin ii on the viability of random-pattern skin flaps in diabetic rat model
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
relation.isAuthorOfPublication1ce7be89-9690-438f-b756-18b50aad8607
relation.isAuthorOfPublicationb2f0fe6f-b16a-49fd-8a29-8bb3d5cb4671
relation.isAuthorOfPublication4ade53af-817c-4347-9383-c44a583a408c
relation.isAuthorOfPublication.latestForDiscovery1ce7be89-9690-438f-b756-18b50aad8607

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