Publication:
Enzymatic generation of highly anticoagulant bovine intestinal heparin

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dc.contributor.authorFu, Li
dc.contributor.authorLi, Kevin
dc.contributor.authorHirakane, Makoto
dc.contributor.authorLin, Lei
dc.contributor.authorGrover, Navdeep
dc.contributor.authorDatta, Payel
dc.contributor.authorYu, Yanlei
dc.contributor.authorZhao, Jing
dc.contributor.authorZhang, Fuming
dc.contributor.authorMousa, Shaker A.
dc.contributor.authorDordick, Jonathan S.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-11-03T12:10:59Z
dc.date.available2022-11-03T12:10:59Z
dc.date.issued2017-10-26
dc.description.abstractUnlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA - HL096972 - HL62244 - HL094463 - GM38060tr_TR
dc.identifier.citationFu, L. vd. (2017). ''Enzymatic generation of highly anticoagulant bovine intestinal heparin''. Journal of Medicinal Chemistry, 60(20), 8673-8679.en_US
dc.identifier.endpage8679tr_TR
dc.identifier.issn0022-2623
dc.identifier.issn1520-4804
dc.identifier.issue20tr_TR
dc.identifier.pubmed28972371tr_TR
dc.identifier.scopus2-s2.0-85032449266tr_TR
dc.identifier.startpage8673tr_TR
dc.identifier.urihttps://doi.org/10.1021/acs.jmedchem.7b01269
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01269?cookieSet=1
dc.identifier.urihttp://hdl.handle.net/11452/29361
dc.identifier.volume60tr_TR
dc.identifier.wos000414114300030
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAmer Chemicalen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectMolecular-weight heparinsen_US
dc.subjectChemoenzymatic synthesisen_US
dc.subjectInduced thrombocytopeniaen_US
dc.subjectPharmaceutical heparinsen_US
dc.subjectChondroitin sulfateen_US
dc.subjectPorcineen_US
dc.subjectBindingen_US
dc.subjectTissuesen_US
dc.subjectDrugsen_US
dc.subject.emtree3 o sulfotransferaseen_US
dc.subject.emtree6 o sulfotransferaseen_US
dc.subject.emtreeAnticoagulant agenten_US
dc.subject.emtreeAntithrombin IIIen_US
dc.subject.emtreeBovine intestinal heparinen_US
dc.subject.emtreeHeparinen_US
dc.subject.emtreeSulfotransferaseen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeAnticoagulant agenten_US
dc.subject.emtreeEnzymeen_US
dc.subject.emtreeHeparinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnticoagulationen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBinding affinityen_US
dc.subject.emtreeBinding siteen_US
dc.subject.emtreeBioengineeringen_US
dc.subject.emtreeChemical compositionen_US
dc.subject.emtreeEnzyme modificationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein bindingen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBiosynthesisen_US
dc.subject.emtreeBovineen_US
dc.subject.emtreeCarbohydrate analysisen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeIntestineen_US
dc.subject.emtreeLeporidaeen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNuclear magnetic resonance spectroscopyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticoagulantsen_US
dc.subject.meshCarbohydrate sequenceen_US
dc.subject.meshCattleen_US
dc.subject.meshEnzymesen_US
dc.subject.meshHeparinen_US
dc.subject.meshIntestinesen_US
dc.subject.meshMagnetic resonance spectroscopyen_US
dc.subject.meshRabbitsen_US
dc.subject.scopusHeparan Sulfate; Heparosan; Glycosaminoglycansen_US
dc.subject.wosChemistry, medicinalen_US
dc.titleEnzymatic generation of highly anticoagulant bovine intestinal heparinen_US
dc.typeArticle
dc.wos.quartileQ1en_US
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Fizyoloji Ana Bilim Dalıtr_TR

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