Publication:
Enzymatic generation of highly anticoagulant bovine intestinal heparin

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dc.contributor.authorFu, Li
dc.contributor.authorLi, Kevin
dc.contributor.authorHirakane, Makoto
dc.contributor.authorLin, Lei
dc.contributor.authorGrover, Navdeep
dc.contributor.authorDatta, Payel
dc.contributor.authorYu, Yanlei
dc.contributor.authorZhao, Jing
dc.contributor.authorZhang, Fuming
dc.contributor.authorMousa, Shaker A.
dc.contributor.authorDordick, Jonathan S.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAG-6956-2021
dc.contributor.scopusid57192959734
dc.date.accessioned2022-11-03T12:10:59Z
dc.date.available2022-11-03T12:10:59Z
dc.date.issued2017-10-26
dc.description.abstractUnlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA - HL096972 - HL62244 - HL094463 - GM38060
dc.identifier.citationFu, L. vd. (2017). ''Enzymatic generation of highly anticoagulant bovine intestinal heparin''. Journal of Medicinal Chemistry, 60(20), 8673-8679.
dc.identifier.endpage8679
dc.identifier.issn0022-2623
dc.identifier.issn1520-4804
dc.identifier.issue20
dc.identifier.pubmed28972371
dc.identifier.scopus2-s2.0-85032449266
dc.identifier.startpage8673
dc.identifier.urihttps://doi.org/10.1021/acs.jmedchem.7b01269
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01269?cookieSet=1
dc.identifier.urihttp://hdl.handle.net/11452/29361
dc.identifier.volume60
dc.identifier.wos000414114300030
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAmer Chemical
dc.relation.collaborationYurt dışı
dc.relation.journalJournal of Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPharmacology & pharmacy
dc.subjectMolecular-weight heparins
dc.subjectChemoenzymatic synthesis
dc.subjectInduced thrombocytopenia
dc.subjectPharmaceutical heparins
dc.subjectChondroitin sulfate
dc.subjectPorcine
dc.subjectBinding
dc.subjectTissues
dc.subjectDrugs
dc.subject.emtree3 o sulfotransferase
dc.subject.emtree6 o sulfotransferase
dc.subject.emtreeAnticoagulant agent
dc.subject.emtreeAntithrombin III
dc.subject.emtreeBovine intestinal heparin
dc.subject.emtreeHeparin
dc.subject.emtreeSulfotransferase
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAnticoagulant agent
dc.subject.emtreeEnzyme
dc.subject.emtreeHeparin
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnticoagulation
dc.subject.emtreeArticle
dc.subject.emtreeBinding affinity
dc.subject.emtreeBinding site
dc.subject.emtreeBioengineering
dc.subject.emtreeChemical composition
dc.subject.emtreeEnzyme modification
dc.subject.emtreeNonhuman
dc.subject.emtreeProtein binding
dc.subject.emtreeAnimal
dc.subject.emtreeBiosynthesis
dc.subject.emtreeBovine
dc.subject.emtreeCarbohydrate analysis
dc.subject.emtreeChemistry
dc.subject.emtreeIntestine
dc.subject.emtreeLeporidae
dc.subject.emtreeMetabolism
dc.subject.emtreeNuclear magnetic resonance spectroscopy
dc.subject.meshAnimals
dc.subject.meshAnticoagulants
dc.subject.meshCarbohydrate sequence
dc.subject.meshCattle
dc.subject.meshEnzymes
dc.subject.meshHeparin
dc.subject.meshIntestines
dc.subject.meshMagnetic resonance spectroscopy
dc.subject.meshRabbits
dc.subject.scopusHeparan Sulfate; Heparosan; Glycosaminoglycans
dc.subject.wosChemistry, medicinal
dc.titleEnzymatic generation of highly anticoagulant bovine intestinal heparin
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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