Publication:
The effect of benzene on the activity of adenosine deaminase in tissues of rats

dc.contributor.buuauthorTurhan, Ali
dc.contributor.buuauthorDere, Egemen
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.researcheridAAH-5068-2021
dc.contributor.scopusid57213904899
dc.contributor.scopusid6603627015
dc.date.accessioned2024-02-27T07:36:54Z
dc.date.available2024-02-27T07:36:54Z
dc.date.issued2007-05-31
dc.description.abstractSwiss Albino (Rat rattus norvegicus) rats were intraperitoneally injected with a 100 mg kg(-1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in the adenosine deaminase (ADA) activity in the liver, kidney and serum of rats were investigated at 0, 2, 4, 8, 16, 32 and 64 h following injection. Serum physiological was administered to each control group. Enzyme activities were measured spectrophotometrically. Our purpose was to further investigations of some diseases caused by benzene, and present evidence of variations in the activity of ADA enzyme effected by benzene. While benzene caused significant inhibitions in ADA activity in the liver at 16 and 32 h and at 0.05 probability level, no significant inhibition or activation occurred at other test periods (hours). ADA activity did not present any significant variation in the kidneys. It was observed that ADA activity displayed similar patterns in the control groups. Comparisons of ADA activities in the two groups showed a statistically significant decrease between 4(th) and 64(th) hours (p < 0.05), demonstrating a direct correlation between benzene and its effects on ADA enzymes.
dc.identifier.citationTurhan, A. ve Dere, E. (2007). ''The effect of benzene on the activity of adenosine deaminase in tissues of rats''. Journal of Biochemistry and Molecular Biology, 40(3), 295-301.
dc.identifier.doihttps://doi.org/10.5483/BMBRep.2007.40.3.295
dc.identifier.endpage301
dc.identifier.issn1225-8687
dc.identifier.issue3
dc.identifier.pubmed17562280
dc.identifier.scopus2-s2.0-34249655226
dc.identifier.startpage295
dc.identifier.urihttp://koreascience.or.kr/article/JAKO200710103425908.page
dc.identifier.urihttps://hdl.handle.net/11452/39988
dc.identifier.volume40
dc.identifier.wos000246859400001
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer Singapore
dc.relation.journalJournal of Biochemistry and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdenosine deaminase
dc.subjectBenzene
dc.subjectKidney
dc.subjectLiver
dc.subjectSerum
dc.subjectExposure
dc.subjectIn-vitro
dc.subjectMicrosomal membrane
dc.subjectCovalent binding
dc.subjectBlood
dc.subjectRisk assessment
dc.subjectMetabolites
dc.subjectC-14 benzene
dc.subjectInhibition
dc.subjectBiochemistry & molecular biology
dc.subjectRattus
dc.subjectRattus norvegicus
dc.subject.scopusS-Phenyl-N-Acetylcysteine; Muconic Acid; Occupational Exposure
dc.subject.wosBiochemistry & molecular biology
dc.titleThe effect of benzene on the activity of adenosine deaminase in tissues of rats
dc.typeArticle
dc.wos.quartileQ3 (Biochemistry & molecular biology)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atWOS
local.indexed.atScopus

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