Publication:
Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH technique

dc.contributor.authorAcar, Hasan
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorKimya, Yalçın
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.departmentTıbbi Genetik Ana Bilim Dalı
dc.contributor.scopusid6602802424
dc.contributor.scopusid55665145000
dc.contributor.scopusid6603919968
dc.date.accessioned2022-04-21T06:53:40Z
dc.date.available2022-04-21T06:53:40Z
dc.date.issued2003-09
dc.description.abstractMeiotic segregation products of carriers with pericentric inversion are very important for assessing the risk of unbalanced forms and appropriate genetic counseling. We investigated the incidence of recombinant and nonrecombinant products of chromosome 1 with pericentric inversion, in the sperm nuclei of the carrier by using triple color fluorescence in situ hybridization (FISH). The centromere specific and telomere specific probes for chromosome 1 were used. In the segregation analysis, 1,636 sperm nuclei were analyzed; 82.5% of the sperms were including normal or inverted chromosome 1, and the dup(p)/del(q) and del(p)/dup(q) recombinant products in sperm nuclei of our carrier were 8.7 and 7.3%, respectively. The number of recombinant products may be dependent on the formation of an inversion loop, which the number of the formation of chiasmata results in the different number of normal/balanced and recombinant products. The use of FISH, using different probe combination, in sperm nuclei has proved to be an accurate approach to determine the meiotic segregation patterns and could help to better establish a reproductive prognosis and genetic counseling.
dc.identifier.citationYakut, T. vd. (2003). “Frequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH technique”. Molecular Reproduction and Development, 66(1), 67-71.
dc.identifier.endpage71
dc.identifier.issn1040-452X
dc.identifier.issue1
dc.identifier.pubmed12874801
dc.identifier.scopus2-s2.0-0042267426
dc.identifier.startpage67
dc.identifier.urihttps://doi.org/10.1002/mrd.10325
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/mrd.10325
dc.identifier.urihttp://hdl.handle.net/11452/25931
dc.identifier.volume66
dc.identifier.wos000184529700010
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.collaborationYurt içi
dc.relation.journalMolecular Reproduction and Development
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemistry and molecular biology
dc.subjectCell biology
dc.subjectDevelopmental biology
dc.subjectReproductive biology
dc.subject.emtreeArticle
dc.subject.emtreeCell nucleus
dc.subject.emtreeCentromere
dc.subject.emtreeChromosome 1
dc.subject.emtreeChromosome chiasm
dc.subject.emtreeChromosome segregation
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeFluorescence in situ hybridization
dc.subject.emtreeGenetic counseling
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeMale
dc.subject.emtreeMeiosis
dc.subject.emtreeNormal human
dc.subject.emtreePericentric chromosome inversion
dc.subject.emtreePriority journal
dc.subject.emtreeSperm
dc.subject.emtreeTelomere
dc.subject.meshCell nucleus
dc.subject.meshChromosome aberrations
dc.subject.meshChromosomes, human, pair 1
dc.subject.meshHumans
dc.subject.meshIn situ hybridization, fluorescence
dc.subject.meshMale
dc.subject.meshSpermatozoa
dc.subject.scopusRobertsonian Chromosome Translocation; Balanced; Chromosome Aberrations
dc.subject.wosBiochemistry and molecular biology
dc.subject.wosCell biology
dc.subject.wosDevelopmental biology
dc.subject.wosReproductive biology
dc.titleFrequency of recombinant and nonrecombinant products of pericentric inversion of chromosome 1 in sperm nuclei of carrier: By FISH technique
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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