Publication:
The relationship between MIB-1 proliferative activity and mitotic index in gastrointestinal stromal tumors

dc.contributor.buuauthorFiliz, Gülaydan
dc.contributor.buuauthorYalçınkaya, Ülviye
dc.contributor.buuauthorGürel, Selim
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorMemik, Faruk
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentCerrahi Patoloji Ana Bilim Dalı
dc.contributor.departmentGastroenteroloji Ana Bilim Dalı
dc.contributor.researcheridEVQ-8652-2022
dc.contributor.researcheridAAH-8924-2021
dc.contributor.researcheridHLH-8209-2023
dc.contributor.researcheridEIS-5114-2022
dc.contributor.researcheridDGO-4135-2022
dc.contributor.scopusid6602693514
dc.contributor.scopusid6508300295
dc.contributor.scopusid7003706434
dc.contributor.scopusid6603810549
dc.contributor.scopusid6701813462
dc.date.accessioned2023-11-01T08:29:44Z
dc.date.available2023-11-01T08:29:44Z
dc.date.issued2007-03
dc.description.abstractBackground/Aims: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors originating from the gastrointestinal canal wall. Although a number of studies are performed concerning prognostic factors, no indicators of recurrence or metastasis could be established. In this study we assessed the prognostic value of MIB-1 proliferative index (PI) in GIST, and whether there was a relationship to any other clinicopathological findings. Methodology: In the study 37 patients with GIST diagnosis were included. The cases were classified as low, intermediate, and high risk groups according to tumor size and mitotic activity. The average PI of 10% in high risk group was set as the cut-off value. Results: Of all the cases, those with a MIB-1 PI over the cut-off value had a significantly shorter survival (Log-rank test, p < 0.05). Likewise cases with small bowel tumors with. a MIB-1 PI over the cut-off value had a significantly shorter survival (Log-rank test, p < 0.05). A statistically significant negative correlation was found between presence of necrosis and survival using McPearson correlation test (p < 0.01). Conclusions: MIB-1 PI and presence of necrosis are possible indicators of prognosis especially in GIST cases of the small bowel.
dc.identifier.citationFiliz, G. vd. (2007). "The relationship between MIB-1 proliferative activity and mitotic index in gastrointestinal stromal tumors". Hepato-Gastroenterology, 54(74), 438-441.
dc.identifier.endpage441
dc.identifier.issn0172-6390
dc.identifier.issue74
dc.identifier.pubmed17523292
dc.identifier.scopus2-s2.0-34248137859
dc.identifier.startpage438
dc.identifier.urihttp://hdl.handle.net/11452/34731
dc.identifier.volume54
dc.identifier.wos000246271800027
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherH.G.E. Update Medical Publishing
dc.relation.journalHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGastroenterology & hepatology
dc.subjectSurgery
dc.subjectGastrointestinal stromal tumor
dc.subjectProliferative indexprognosis
dc.subjectMib-1
dc.subjectPrognostic value
dc.subjectDna-ploidy
dc.subjectImmunoreactivity
dc.subjectCell
dc.subjectExpression
dc.subjectStomach
dc.subjectKi-67
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeArticle
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeGastrointestinal stromal tumor
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMitosis index
dc.subject.emtreePriority journal
dc.subject.emtreeRisk factor
dc.subject.emtreeSurvival
dc.subject.emtreeTumor localization
dc.subject.emtreeTumor volume
dc.subject.emtreeKi 67 antigen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBiopsy
dc.subject.meshCell division
dc.subject.meshFemale
dc.subject.meshGastrointestinal stromal tumors
dc.subject.meshHumans
dc.subject.meshImmunoenzyme techniques
dc.subject.meshIntestinal mucosa
dc.subject.meshKi-67 antigen
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshMitotic index
dc.subject.meshPrognosis
dc.subject.meshSurvival analysis
dc.subject.scopusGastrointestinal Stromal Tumors; Imatinib; Cancer
dc.subject.wosGastroenterology & hepatology
dc.subject.wosSurgery
dc.titleThe relationship between MIB-1 proliferative activity and mitotic index in gastrointestinal stromal tumors
dc.typeArticle
dc.wos.quartileQ3 (Surgery)
dc.wos.quartileQ4 (Gastroenterology & hepatology)
dc.wos.quartileQ3
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Cerrahi Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Gastroenteroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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