Publication:
Uridine treatment prevents REM sleep deprivation-induced learning and memory impairment

dc.contributor.authorSüyen, Güldal Güleç
dc.contributor.buuauthorÖcalan, Büşra
dc.contributor.buuauthorÇakır, Ayşen
dc.contributor.buuauthorKoç, Cansu
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-6097-5585
dc.contributor.orcid0000-0001-7729-7373
dc.contributor.orcid0000-0002-3405-3640
dc.contributor.orcid0000-0003-0841-8201
dc.contributor.researcheridAAA-4754-2022
dc.contributor.researcheridA-6819-2018
dc.contributor.researcheridN-9927-2019
dc.contributor.researcheridAAL-1786-2020
dc.contributor.researcheridAAG-7070-2021
dc.contributor.scopusid57191911801
dc.contributor.scopusid57191915856
dc.contributor.scopusid57205607904
dc.contributor.scopusid6602597846
dc.date.accessioned2023-03-27T06:59:45Z
dc.date.available2023-03-27T06:59:45Z
dc.date.issued2019-01-21
dc.description.abstractPrevious studies have shown that sleep plays an important role in cognitive functions and sleep deprivation impairs learning and memory. Uridine is the main pyrimidine nucleoside found in human blood circulation and has beneficial effects on cognitive functions. The aim of the present study was to investigate the effects of uridine administration on learning and memory impairment in sleep-deprived rats. Flower pot method was used to induce REM sleep deprivation. Uridine-treated groups received 1 mmol/kg uridine and control groups received 1 ml/kg saline (0.9% NaCl) twice a day for four days and once a day on the 5th day intraperitoneally. Learning and memory performances were measured using Morris water maze (MWM) test. We also measured the ratios of total calcium-calmodulin dependent kinase II (tCaMKII)/beta-tubulin and phosphorylated cyclic adenosine monophosphate (cAMP) response element binding protein (pCREB)/beta-tubulin, long-term potentiation (LTP) related molecules, using western blot analysis on the hippocampus. The results showed that REM sleep deprivation impaired learning and memory and also decreased the ratios of tCaMKII and pCREB. Uridine treatment enhanced learning and memory parameters in REM sleep-deprived rats. Additionally, decreases in tCaMKII and pCREB were prevented by uridine treatment. These data suggest that administration of uridine for five consecutive days prevents REM sleep deprivation-induced deficits in learning and memory associated with enhanced tCaMKII and pCREB ratios in the hippocampus.
dc.identifier.citationÖcalan, B. vd. (2019). ''Uridine treatment prevents REM sleep deprivation-induced learning and memory impairment''. Neuroscience Research, 148, 42-48.
dc.identifier.endpage48
dc.identifier.issn0168-0102
dc.identifier.issn1872-8111
dc.identifier.pubmed30685492
dc.identifier.scopus2-s2.0-85060754155
dc.identifier.startpage42
dc.identifier.urihttps://doi.org/10.1016/j.neures.2019.01.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0168010218306552
dc.identifier.urihttp://hdl.handle.net/11452/31752
dc.identifier.volume148
dc.identifier.wos000486296200006
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.indexed.wosSSCI
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.journalNeuroscience Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectWestern blot
dc.subjectBehavior
dc.subjectHippocampus
dc.subjectMorris water maze
dc.subjectLong-term potentiation
dc.subjectCalmodulin kinase-II
dc.subjectCdp-choline
dc.subjectDocosahexaenoic acid
dc.subjectCreb phosphorylation
dc.subjectBRAIN
dc.subjectStress
dc.subjectIncreases
dc.subjectLtp
dc.subjectSupplementation
dc.subject.emtreeBeta tubulin
dc.subject.emtreeCalcium calmodulin dependent protein kinase II
dc.subject.emtreeCyclic AMP
dc.subject.emtreeCyclic AMP responsive element binding protein
dc.subject.emtreePhosphotransferase
dc.subject.emtreeSodium chloride
dc.subject.emtreeUridine
dc.subject.emtreeCalcium calmodulin dependent protein kinase II
dc.subject.emtreeTubulin
dc.subject.emtreeAnimal experiment;
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeBehavior change
dc.subject.emtreeBehavior change
dc.subject.emtreeControlled study
dc.subject.emtreeDrug effect
dc.subject.emtreeFlower
dc.subject.emtreeHippocampus
dc.subject.emtreeLong term potentiation
dc.subject.emtreeMale
dc.subject.emtreeMemory disorder
dc.subject.emtreeMolecular biology
dc.subject.emtreeMorris water maze test
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeRem sleep deprivation
dc.subject.emtreeTreatment indication
dc.subject.emtreeAnimal
dc.subject.emtreeDrug therapy
dc.subject.emtreeMaze test
dc.subject.emtreeMetabolism
dc.subject.emtreeShort term memory
dc.subject.emtreeShort term memory
dc.subject.emtreeWistar rat
dc.subject.meshAnimals
dc.subject.meshCalcium-Calmodulin-Dependent Protein Kinase Type 2
dc.subject.meshHippocampus
dc.subject.meshMale
dc.subject.meshMaze learning
dc.subject.meshMemory, short-term
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshSleep deprivation
dc.subject.meshTubulin
dc.subject.scopusMemory Consolidation; REM Sleep; Slow Wave Sleep
dc.subject.wosNeurosciences
dc.titleUridine treatment prevents REM sleep deprivation-induced learning and memory impairment
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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