Publication: Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties
dc.contributor.author | Yılmaz, Sunde Süslüer | |
dc.contributor.author | Büyükgüngör, Orhan | |
dc.contributor.buuauthor | Yılmaz, Veysel Turan | |
dc.contributor.buuauthor | Göçmen, Elif | |
dc.contributor.buuauthor | İçsel, Ceyda | |
dc.contributor.buuauthor | Cengiz, Murat | |
dc.contributor.department | Veterinerlik Fakültesi | |
dc.contributor.department | Fen Edebiyat Fakültesi | |
dc.contributor.department | Kimya Bölümü | |
dc.contributor.department | Klinik Öncesi Bilimler Bölümü | |
dc.contributor.orcid | 0000-0002-2849-3332 | |
dc.contributor.orcid | 0000-0002-2717-2430 | |
dc.contributor.researcherid | AAI-3342-2021 | |
dc.contributor.researcherid | L-7238-2018 | |
dc.contributor.researcherid | ABE-5935-2020 | |
dc.contributor.scopusid | 7006269202 | |
dc.contributor.scopusid | 55992981200 | |
dc.contributor.scopusid | 55551960400 | |
dc.contributor.scopusid | 16635026700 | |
dc.date.accessioned | 2022-09-13T08:28:21Z | |
dc.date.available | 2022-09-13T08:28:21Z | |
dc.date.issued | 2014-01 | |
dc.description.abstract | A series of new silver(I) saccharinate (sac) complexes, [Ag-2(sac)(2)(mu-dppm)H2O]center dot H2O (1), {[Ag-2(mu-sac)(2)(mu-dppe)]center dot 3H(2)O center dot CH2Cl2} (n) (2), [Ag-2(mu-sac)(2)(mu-dppp)] (n) (3), and [Ag(sac)(mu-dppb)] (n) (4) [dppm is 1,1-bis(diphenylphosphino)methane, dppe is 1,2-bis(diphenylphosphino)ethane, dppp is 1,3-bis(diphenylphosphino)propane, and dppb is 1,4-bis(diphenylphosphino)butane], have been synthesized and characterized by C, H, N elemental analysis, IR spectroscopy, H-1 NMR, C-13 NMR, and P-31 NMR spectroscopy, electrospray ionization mass spectrometry, and thermogravimetry-differential thermal analysis. Single-crystal X-ray studies show that the diphosphanes act as bridging ligands to yield a dinuclear complex (1) and one-dimensional coordination polymers (2 and 4), whereas the sac ligand adopts a mu(2)-N/O bridging mode in 2, and is N-coordinated in 1 and 4. The interaction of the silver(I) complexes with fish sperm DNA was investigated using UV-vis spectroscopy, fluorescence spectroscopy, and agarose gel electrophoresis. The binding studies indicate that the silver(I) complexes can interact with fish sperm DNA through intercalation, and complexes 1 and 3 have the highest binding affinity. The gel electrophoresis assay further confirms the binding of the complexes with the pBR322 plasmid DNA. The minimum inhibitory concentrations of the complexes indicate that complex 1 exhibits very high antibacterial activity against standard bacterial strains of Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus, being much higher than those of AgNO3, silver sulfadiazine, ciprofloxacin, and gentamicin. Moreover, complexes 1-3 exhibit very high cytotoxic activity against A549 and MCF-7 cancer cell lines, compared with AgNO3 and cisplatin. The bacterial and cell growth inhibitions of the silver(I) complexes are closely related to their DNA binding affinities. | |
dc.identifier.citation | Yılmaz, V. T. vd. (2014). "Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties". Journal of Biological Inorganic Chemistry, 19(1), 29-44. | |
dc.identifier.endpage | 44 | |
dc.identifier.issn | 0949-8257 | |
dc.identifier.issn | 1432-1327 | |
dc.identifier.issue | 1 | |
dc.identifier.pubmed | 24132752 | |
dc.identifier.scopus | 2-s2.0-84891851872 | |
dc.identifier.startpage | 29 | |
dc.identifier.uri | https://doi.org/10.1007/s00775-013-1052-y | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00775-013-1052-y | |
dc.identifier.uri | http://hdl.handle.net/11452/28666 | |
dc.identifier.volume | 19 | |
dc.identifier.wos | 000329236300003 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Springer | |
dc.relation.bap | UAP(F)-2011/36 | |
dc.relation.collaboration | Yurt içi | |
dc.relation.journal | Journal of Biological Inorganic Chemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Silver(I) complexes | |
dc.subject | Saccharinate | |
dc.subject | Tertiary diphosphanes | |
dc.subject | DNA binding | |
dc.subject | Antibacterial activity | |
dc.subject | Metalmultinuclear molecules | |
dc.subject | Ray crystal-structure | |
dc.subject | Antimicrobial activities | |
dc.subject | Coordination polymers | |
dc.subject | Thermal analysis | |
dc.subject | Platinum(II) | |
dc.subject | Complexes | |
dc.subject | Carboxylate complexes | |
dc.subject | Topical therapy | |
dc.subject | Ir-spectra | |
dc.subject | Palladium(II) | |
dc.subject | Biochemistry & molecular biology | |
dc.subject | Chemistry | |
dc.subject.emtree | Antiinfective agent | |
dc.subject.emtree | Antineoplastic agent | |
dc.subject.emtree | Ciprofloxacin | |
dc.subject.emtree | Cisplatin | |
dc.subject.emtree | DNA | |
dc.subject.emtree | Gentamicin | |
dc.subject.emtree | Plasmid DNA | |
dc.subject.emtree | Silver nitrate | |
dc.subject.emtree | Silver saccharinate 1,1 bis(diphenylphosphino)methane complex | |
dc.subject.emtree | Silver saccharinate 1,2 bis(diphenylphosphino)ethane complex | |
dc.subject.emtree | Silver saccharinate 1,3 bis(diphenylphosphino)propane complex | |
dc.subject.emtree | Silver saccharinate 1,4 bis(diphenylphosphino)butane complex | |
dc.subject.emtree | Sulfadiazine silver | |
dc.subject.emtree | Unclassified drug | |
dc.subject.emtree | Agar gel electrophoresis | |
dc.subject.emtree | Animal cell | |
dc.subject.emtree | Antibacterial activity | |
dc.subject.emtree | Antineoplastic activity | |
dc.subject.emtree | Article | |
dc.subject.emtree | Bacterial growth | |
dc.subject.emtree | Bacterial strain | |
dc.subject.emtree | Binding affinity | |
dc.subject.emtree | Cell growth | |
dc.subject.emtree | Cell strain MCF 7 | |
dc.subject.emtree | Concentration response | |
dc.subject.emtree | Controlled study | |
dc.subject.emtree | Differential scanning calorimetry | |
dc.subject.emtree | Drug DNA binding | |
dc.subject.emtree | Drug structure | |
dc.subject.emtree | Electrospray mass spectrometry | |
dc.subject.emtree | Escherichia coli | |
dc.subject.emtree | Fish | |
dc.subject.emtree | Fluorescence spectroscopy | |
dc.subject.emtree | Growth inhibition | |
dc.subject.emtree | Human | |
dc.subject.emtree | Human cell | |
dc.subject.emtree | In vitro study | |
dc.subject.emtree | Infrared spectroscopy | |
dc.subject.emtree | Intercalation complex | |
dc.subject.emtree | Male | |
dc.subject.emtree | Minimum inhibitory concentration | |
dc.subject.emtree | Nonhuman | |
dc.subject.emtree | Nuclear magnetic resonance spectroscopy | |
dc.subject.emtree | Priority journal | |
dc.subject.emtree | Salmonella typhimurium | |
dc.subject.emtree | Sperm | |
dc.subject.emtree | Staphylococcus aureus | |
dc.subject.emtree | Thermogravimetry | |
dc.subject.emtree | Ultraviolet spectroscopy | |
dc.subject.emtree | X ray crystallography | |
dc.subject.mesh | Anti-bacterial agents | |
dc.subject.mesh | Antineoplastic agents | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Bacterial infections | |
dc.subject.mesh | Cell line | |
dc.subject.mesh | Cell line, tumor | |
dc.subject.mesh | Coordination complexes | |
dc.subject.mesh | DNA | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Models, molecular | |
dc.subject.mesh | Neoplasms | |
dc.subject.mesh | Phosphines | |
dc.subject.mesh | Zinc | |
dc.subject.scopus | Complex; Diphenyl Ethers; Silver | |
dc.subject.wos | Biochemistry & molecular biology | |
dc.subject.wos | Chemistry, inorganic & nuclear | |
dc.title | Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties | |
dc.type | Article | |
dc.wos.quartile | Q3 (Biochemistry & molecular biology) | |
dc.wos.quartile | Q1 (Chemistry) | |
dspace.entity.type | Publication | |
local.contributor.department | Fen Edebiyat Fakültesi/Kimya Bölümü | |
local.contributor.department | Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü | |
local.indexed.at | PubMed | |
local.indexed.at | WOS |
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