Publication:
Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties

dc.contributor.authorYılmaz, Sunde Süslüer
dc.contributor.authorBüyükgüngör, Orhan
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.buuauthorGöçmen, Elif
dc.contributor.buuauthorİçsel, Ceyda
dc.contributor.buuauthorCengiz, Murat
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentKimya Bölümü
dc.contributor.departmentKlinik Öncesi Bilimler Bölümü
dc.contributor.orcid0000-0002-2849-3332
dc.contributor.orcid0000-0002-2717-2430
dc.contributor.researcheridAAI-3342-2021
dc.contributor.researcheridL-7238-2018
dc.contributor.researcheridABE-5935-2020
dc.contributor.scopusid7006269202
dc.contributor.scopusid55992981200
dc.contributor.scopusid55551960400
dc.contributor.scopusid16635026700
dc.date.accessioned2022-09-13T08:28:21Z
dc.date.available2022-09-13T08:28:21Z
dc.date.issued2014-01
dc.description.abstractA series of new silver(I) saccharinate (sac) complexes, [Ag-2(sac)(2)(mu-dppm)H2O]center dot H2O (1), {[Ag-2(mu-sac)(2)(mu-dppe)]center dot 3H(2)O center dot CH2Cl2} (n) (2), [Ag-2(mu-sac)(2)(mu-dppp)] (n) (3), and [Ag(sac)(mu-dppb)] (n) (4) [dppm is 1,1-bis(diphenylphosphino)methane, dppe is 1,2-bis(diphenylphosphino)ethane, dppp is 1,3-bis(diphenylphosphino)propane, and dppb is 1,4-bis(diphenylphosphino)butane], have been synthesized and characterized by C, H, N elemental analysis, IR spectroscopy, H-1 NMR, C-13 NMR, and P-31 NMR spectroscopy, electrospray ionization mass spectrometry, and thermogravimetry-differential thermal analysis. Single-crystal X-ray studies show that the diphosphanes act as bridging ligands to yield a dinuclear complex (1) and one-dimensional coordination polymers (2 and 4), whereas the sac ligand adopts a mu(2)-N/O bridging mode in 2, and is N-coordinated in 1 and 4. The interaction of the silver(I) complexes with fish sperm DNA was investigated using UV-vis spectroscopy, fluorescence spectroscopy, and agarose gel electrophoresis. The binding studies indicate that the silver(I) complexes can interact with fish sperm DNA through intercalation, and complexes 1 and 3 have the highest binding affinity. The gel electrophoresis assay further confirms the binding of the complexes with the pBR322 plasmid DNA. The minimum inhibitory concentrations of the complexes indicate that complex 1 exhibits very high antibacterial activity against standard bacterial strains of Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus, being much higher than those of AgNO3, silver sulfadiazine, ciprofloxacin, and gentamicin. Moreover, complexes 1-3 exhibit very high cytotoxic activity against A549 and MCF-7 cancer cell lines, compared with AgNO3 and cisplatin. The bacterial and cell growth inhibitions of the silver(I) complexes are closely related to their DNA binding affinities.
dc.identifier.citationYılmaz, V. T. vd. (2014). "Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties". Journal of Biological Inorganic Chemistry, 19(1), 29-44.
dc.identifier.endpage44
dc.identifier.issn0949-8257
dc.identifier.issn1432-1327
dc.identifier.issue1
dc.identifier.pubmed24132752
dc.identifier.scopus2-s2.0-84891851872
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.1007/s00775-013-1052-y
dc.identifier.urihttps://link.springer.com/article/10.1007/s00775-013-1052-y
dc.identifier.urihttp://hdl.handle.net/11452/28666
dc.identifier.volume19
dc.identifier.wos000329236300003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.bapUAP(F)-2011/36
dc.relation.collaborationYurt içi
dc.relation.journalJournal of Biological Inorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilver(I) complexes
dc.subjectSaccharinate
dc.subjectTertiary diphosphanes
dc.subjectDNA binding
dc.subjectAntibacterial activity
dc.subjectMetalmultinuclear molecules
dc.subjectRay crystal-structure
dc.subjectAntimicrobial activities
dc.subjectCoordination polymers
dc.subjectThermal analysis
dc.subjectPlatinum(II)
dc.subjectComplexes
dc.subjectCarboxylate complexes
dc.subjectTopical therapy
dc.subjectIr-spectra
dc.subjectPalladium(II)
dc.subjectBiochemistry & molecular biology
dc.subjectChemistry
dc.subject.emtreeAntiinfective agent
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCiprofloxacin
dc.subject.emtreeCisplatin
dc.subject.emtreeDNA
dc.subject.emtreeGentamicin
dc.subject.emtreePlasmid DNA
dc.subject.emtreeSilver nitrate
dc.subject.emtreeSilver saccharinate 1,1 bis(diphenylphosphino)methane complex
dc.subject.emtreeSilver saccharinate 1,2 bis(diphenylphosphino)ethane complex
dc.subject.emtreeSilver saccharinate 1,3 bis(diphenylphosphino)propane complex
dc.subject.emtreeSilver saccharinate 1,4 bis(diphenylphosphino)butane complex
dc.subject.emtreeSulfadiazine silver
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAgar gel electrophoresis
dc.subject.emtreeAnimal cell
dc.subject.emtreeAntibacterial activity
dc.subject.emtreeAntineoplastic activity
dc.subject.emtreeArticle
dc.subject.emtreeBacterial growth
dc.subject.emtreeBacterial strain
dc.subject.emtreeBinding affinity
dc.subject.emtreeCell growth
dc.subject.emtreeCell strain MCF 7
dc.subject.emtreeConcentration response
dc.subject.emtreeControlled study
dc.subject.emtreeDifferential scanning calorimetry
dc.subject.emtreeDrug DNA binding
dc.subject.emtreeDrug structure
dc.subject.emtreeElectrospray mass spectrometry
dc.subject.emtreeEscherichia coli
dc.subject.emtreeFish
dc.subject.emtreeFluorescence spectroscopy
dc.subject.emtreeGrowth inhibition
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIn vitro study
dc.subject.emtreeInfrared spectroscopy
dc.subject.emtreeIntercalation complex
dc.subject.emtreeMale
dc.subject.emtreeMinimum inhibitory concentration
dc.subject.emtreeNonhuman
dc.subject.emtreeNuclear magnetic resonance spectroscopy
dc.subject.emtreePriority journal
dc.subject.emtreeSalmonella typhimurium
dc.subject.emtreeSperm
dc.subject.emtreeStaphylococcus aureus
dc.subject.emtreeThermogravimetry
dc.subject.emtreeUltraviolet spectroscopy
dc.subject.emtreeX ray crystallography
dc.subject.meshAnti-bacterial agents
dc.subject.meshAntineoplastic agents
dc.subject.meshBacteria
dc.subject.meshBacterial infections
dc.subject.meshCell line
dc.subject.meshCell line, tumor
dc.subject.meshCoordination complexes
dc.subject.meshDNA
dc.subject.meshHumans
dc.subject.meshModels, molecular
dc.subject.meshNeoplasms
dc.subject.meshPhosphines
dc.subject.meshZinc
dc.subject.scopusComplex; Diphenyl Ethers; Silver
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosChemistry, inorganic & nuclear
dc.titleDi- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties
dc.typeArticle
dc.wos.quartileQ3 (Biochemistry & molecular biology)
dc.wos.quartileQ1 (Chemistry)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümü
local.contributor.departmentVeterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü
local.indexed.atPubMed
local.indexed.atWOS

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