The role of c-reactive protein on detection of postoperative atrial fibrillation in cardiac surgery: A systematic review and meta-analysis

Abstract

Background: In this review, we aimed to analyze the efficacy of C-reactive protein levels measured in preoperative period on detection of postoperative atrial fibrillation developing after cardiac surgery.Methods: Literature screening was performed at Pubmed database without date limitation. The results of trials were evaluated with random or fixed effect model according to the heterogenity. The statistical evaluation was performed by using Comprehensive Meta Analysis version 2 software.Results: Twenty-five articles containing the inclusion criteria and a total of 4,058 patients were included to the meta-analysis. Effect sizes were heterogeneous (Q=135.80, df(Q)=24, p=0.00, 12=82.32%). Results of analysis according to random effect model were OR=1.52, 95% CI 1.11-2.06, Z=4.48 and p<0.05.Conclusion: The analysis results showed that levels of preoperative standard serum C-reactive protein, not high sensitivity C-reactive protein, were associated with postoperative atrial fibrillation developing after cardiac surgery.