Publication:
Clinical value of a mucin-like carcinoma-associated antigen in monitoring breast cancer patients in comparison with CA 15-3

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dc.contributor.authorMiserez, Andre R.
dc.contributor.authorMüllerbrand, Jan
dc.contributor.authorWalther, Eike
dc.contributor.authorFridrich, Raimund
dc.contributor.authorMäcke, Helmut
dc.contributor.buuauthorGüneş, İlknur
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNükleer Tıp Ana Bilim Dalı
dc.date.accessioned2021-06-29T07:50:39Z
dc.date.available2021-06-29T07:50:39Z
dc.date.issued1991
dc.description.abstractA new tumour marker, mucin-like carcinoma-associated antigen (MCA), was evaluated in 176 breast cancer patients classified either as free of tumour (NED, n = 141) or as having metastases (PD, n = 35). During the 5 year follow-up, 842 measurements of MCA and 363 measurements of CA 15-3 were done. MCA levels were significantly increased in the PD group (P = 0.0001) but not in the NED group. The sensitivities of the MCA and the CA 15-3 assays were 84% and 78% and the specificities were 81% and 78%, respectively. The negative predictive value of 97% for MCA was significantly higher (P = 0.0001) than the 88% for CA 15-3. Thus the MCA enzyme immunoassay is at least equivalent to the CA 15-3 test and is recommended in the assessment of metastatic spread or tumour recurrence in breast cancer patients.
dc.identifier.citationMiserez, A. R. vd. (1991). ''Clinical value of a mucin-like carcinoma-associated antigen in monitoring breast cancer patients in comparison with CA 15-3''. European Journal of Cancer, 27(2), 126-131.
dc.identifier.endpage131
dc.identifier.issn0959-8049
dc.identifier.issue2
dc.identifier.pubmed1827273
dc.identifier.scopus2-s2.0-0025973380
dc.identifier.startpage126
dc.identifier.urihttps://doi.org/10.1016/0277-5379(91)90468-S
dc.identifier.urihttp://hdl.handle.net/11452/20892
dc.identifier.volume27
dc.identifier.wosA1991FD47000007
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.collaborationYurt dışı
dc.relation.journalEuropean Journal of Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMonoclonal-antibodies
dc.subjectCA 15-3
dc.subjectTumor-markers
dc.subjectDisease
dc.subjectDiagnosis
dc.subjectEpitopes
dc.subjectMCA
dc.subjectOncology
dc.subject.wosOncology
dc.titleClinical value of a mucin-like carcinoma-associated antigen in monitoring breast cancer patients in comparison with CA 15-3
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nükleer Tıp Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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