Publication:
A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions

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dc.contributor.buuauthorTopal, Ersun
dc.contributor.buuauthorÖztürk, Ersin
dc.contributor.buuauthorŞen, Gürol
dc.contributor.buuauthorYerci, Ömer
dc.contributor.buuauthorYılmazlar, Tuncay
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGenel Cerrahi Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.scopusid16069863000
dc.contributor.scopusid35070171400
dc.contributor.scopusid23013375200
dc.contributor.scopusid6603810549
dc.contributor.scopusid6701800362
dc.date.accessioned2021-12-30T11:13:04Z
dc.date.available2021-12-30T11:13:04Z
dc.date.issued2010-02
dc.description.abstractPurpose : Three different drugs affecting the coagulation process at various stages were studied for their effectiveness in preventing intra-peritoneal adhesion formation in rats. Material and Methods: Forty female Wistar-Albino rats divided into four groups based on the drugs administered during the experimental laparotomy and caecal abrasion : the control group - no drug administered, the intra-peritoneal tissue plasminogen activator (TPA) group, the subcutaneous fondaparinux sodium (FS) group and the intra-peritoneal activated drotrecogin alfa (ADA) group. After two weeks, intra-peritoneal adhesions were macroscopically and micro-scopically scored. Results : The macroscopic scores of the three groups were similar but all lower than the control group (p = 0.002). Inflammation (p = 0.023) and fibrosis (p = 0.019) scores were lower in just the ADA group when compared to the control group. Conclusions : All three agents were effective in preventing adhesions when compared to the control group. Nevertheless, ADA seemed the most effective except when considering clinical applicability, in which case FS seemed to offer the greatest advantage.
dc.identifier.citationTopal, E. vd. (2010). "A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions". Acta Chirurgica Belgica, 110(1), 71-75.
dc.identifier.endpage75
dc.identifier.issn0001-5458
dc.identifier.issue1
dc.identifier.pubmed20306914
dc.identifier.scopus2-s2.0-77949357377
dc.identifier.startpage71
dc.identifier.urihttps://doi.org/10.1080/00015458.2010.11680569
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20306914/
dc.identifier.urihttp://hdl.handle.net/11452/23764
dc.identifier.volume110
dc.identifier.wos000275654000017
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTissue plasminogen activator
dc.subjectFondaparinux sodium
dc.subjectAdhesions
dc.subjectPeritoneum
dc.subjectMolecular-weight heparin
dc.subjectPlasminogen-activator
dc.subjectSurgery
dc.subjectObstruction
dc.subjectTrauma
dc.subjectSurgery
dc.subject.scopusMeglumine Diatrizoate; Tissue Adhesions; Icodextrin
dc.subject.wosSurgery
dc.titleA comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Genel Cerrahi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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