Diagnostic value of serum high mobility group box protein 1 (HMGB1) and soluble CD163 (sCD163) levels in brucellosis

Abstract

Both CD4+ and CD8+ T lymphocytes play critical roles in immunity to Brucella, in part because they secrete IFN-c and activate the bactericidal functions in macrophages. Therefore, use of markers which can evaluate macrophage activation may have diagnostic and prognostic importance. High mobility group-box 1 protein (HMGB1) is a late-onset proinflammatory cytokine secreted from activated macrophages. Soluble hemoglobin scavenger receptor (sCD163) is a specific marker of antiinflammatory macrophages. The aim of this study was to test potential associations of serum levels of HMGB1 and sCD163 with Brucellosis and its acute, subacute and chronic forms