Publication:
Unilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy

dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNeonatoloji Ana Bilim Dalı
dc.contributor.scopusid23994946300
dc.contributor.scopusid16679325400
dc.contributor.scopusid7003323615
dc.date.accessioned2022-06-20T11:07:46Z
dc.date.available2022-06-20T11:07:46Z
dc.date.issued2008
dc.description.abstractLamotrigine (LTG) has been used in epilepsia patients for treatment of partial seizures. It can cross the placenta and there are limited data about its use in pregnancy and foetal adverse effects. Extremity and cardiac malformations, dysmorphic facial appearance, coanal atresia and upper respiratory and gastrointestinal anomalies have been reported because of LTG use in pregnancy. Oxcarbazepine (OXC) is one of the new antiepileptic agents. Although the drug and its metabolites can easily pass from placenta to the foetus, available data suggest that it can be safely used during pregnancy because no teratogenicity has been reported. One infant with atrial septal defect and patent ductus arteriosus due to use of LTG and OXC in pregnancy has been reported in literature. Here, we report a female infant with micrognatia, low-set ears, facial dysmorphism and unilateral radius aplasia born to a mother who used LTG 100 mg/day and OXC 1200 mg/day during pregnancy for seizures. To our knowledge, this is the first major anomaly case associated with the combined use of these drugs. This case can provide useful data about the teratogenicity of LTG and OXC combination therapy.
dc.identifier.citationÇetinkaya, M. vd. (2008). "Unilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy". Journal of Maternal-Fetal and Neonatal Medicine, 21(12), 927-930.
dc.identifier.endpage930
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue12
dc.identifier.pubmed19065466
dc.identifier.scopus2-s2.0-57449120934
dc.identifier.startpage927
dc.identifier.urihttps://doi.org/10.1080/14767050802366210
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/14767050802366210
dc.identifier.urihttp://hdl.handle.net/11452/27314
dc.identifier.volume21
dc.identifier.wos000262645800013
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalJournal of Maternal-Fetal and Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectObstetrics & gynecology
dc.subjectLamotrigine
dc.subjectOxcarbazepine
dc.subjectPolytherapy
dc.subjectPregnancy
dc.subjectUnilateral radius aplasia
dc.subjectAntiepileptic drugs
dc.subjectEpilepsy
dc.subjectTeratogenicity
dc.subjectMalformations
dc.subjectExposure
dc.subject.emtreeCarbamazepine
dc.subject.emtreeLamotrigine
dc.subject.emtreeOxcarbazepine
dc.subject.emtreeApgar score
dc.subject.emtreeArticle
dc.subject.emtreeBlood chemistry
dc.subject.emtreeBone radiography
dc.subject.emtreeCase report
dc.subject.emtreeCesarean section
dc.subject.emtreeChromosome analysis
dc.subject.emtreeDrug substitution
dc.subject.emtreeDrug withdrawal
dc.subject.emtreeFace dysmorphia
dc.subject.emtreeFemale
dc.subject.emtreeFlexion contracture
dc.subject.emtreeGestation period
dc.subject.emtreeHuman
dc.subject.emtreeLow set ear
dc.subject.emtreeMicrognathia
dc.subject.emtreeNewborn
dc.subject.emtreeNuclear magnetic resonance imaging
dc.subject.emtreePhysical examination
dc.subject.emtreePositive end expiratory pressure
dc.subject.emtreePregnancy
dc.subject.emtreePriority journal
dc.subject.emtreeRadius aplasia
dc.subject.emtreeSeizure
dc.subject.meshAnticonvulsants
dc.subject.meshCarbamazepine
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, newborn
dc.subject.meshMaxillofacial abnormalities
dc.subject.meshPregnancy
dc.subject.meshRadius
dc.subject.meshTriazines
dc.subject.meshUpper extremity deformities
dc.subject.meshCongenital
dc.subject.scopusAnticonvulsants; Valproic Acid; Lamotrigine
dc.subject.wosObstetrics & gynecology
dc.titleUnilateral radius aplasia due to lamotrigine and oxcarbazepine use in pregnancy
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Neonatoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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