Publication:
The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia

dc.contributor.authorAyyildiz, T.
dc.contributor.authorErturk, B.
dc.contributor.buuauthorDolar, E.
dc.contributor.buuauthorDOLAR, MAHMUT ENVER
dc.contributor.buuauthorUgras, N.
dc.contributor.buuauthorUĞRAŞ, NESRİN
dc.contributor.buuauthorDizdar, O. S.
dc.contributor.buuauthorAdim, S. B.
dc.contributor.buuauthorYerci, O.
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.researcheridD-6213-2013
dc.contributor.researcheridAAG-9177-2021
dc.date.accessioned2024-06-05T12:27:21Z
dc.date.available2024-06-05T12:27:21Z
dc.date.issued2021-04-01
dc.description.abstractBackground: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors.
dc.identifier.doi10.4103/njcp.njcp_302_20
dc.identifier.endpage613
dc.identifier.issn1119-3077
dc.identifier.issue4
dc.identifier.startpage608
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_302_20
dc.identifier.urihttps://hdl.handle.net/11452/41779
dc.identifier.volume24
dc.identifier.wos000640572500022
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalNigerian Journal Of Clinical Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdiponectin
dc.subjectAdipo-r1
dc.subjectR2
dc.subjectGastric carcinoma
dc.subjectIntestinal metaplasia
dc.subjectHelicobacter pylori
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleThe expression and relationship of adipo R1/R2 in gastric intestinal metaplasia
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Gastroentoloji Ana Bilim Dalı
relation.isAuthorOfPublication9f100906-5262-4b98-9828-2958eac56d15
relation.isAuthorOfPublicationdd613ef2-8621-4e20-8c27-0393f7c8e632
relation.isAuthorOfPublication.latestForDiscovery9f100906-5262-4b98-9828-2958eac56d15

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