Publication: Mouse model recapitulates the phenotypic heterogeneity of human adult T-cell leukemia/lymphoma in bone
dc.contributor.author | Kohart, Nicole A. | |
dc.contributor.author | Elshafae, Said M. | |
dc.contributor.author | Supsahvad, Wachirapan | |
dc.contributor.author | Alasonyalılar-Demirer, Aylin | |
dc.contributor.author | Panfil, Amanda R. | |
dc.contributor.author | Xiang Jingyu | |
dc.contributor.author | Dirksen, Wessel P. | |
dc.contributor.author | Veis, Deborah J. | |
dc.contributor.author | Green, Patrick L. | |
dc.contributor.author | Weilbaecher, Katherine N. | |
dc.contributor.author | Rosol, Thomas J. | |
dc.contributor.buuauthor | ALASONYALILAR DEMİRER, AYLİN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı | |
dc.contributor.researcherid | EKS-2415-2022 | |
dc.date.accessioned | 2024-07-24T10:34:15Z | |
dc.date.available | 2024-07-24T10:34:15Z | |
dc.date.issued | 2019-12-01 | |
dc.description.abstract | Adult T-cell leukemia/lymphoma has a unique relationship to bone including latency in the marrow, and development of bone invasion, osteolytic tumors and humoral hypercalcemia of malignancy. To study these conditions, we established and characterized a novel mouse model of ATL bone metastasis. Patient-derived ATL cell lines including three that do not express HTLV-1 oncoprotein Tax (ATL-ED, RV-ATL, TL-0m1), an in vitro transformed human T-cell line with high Tax expression (HT-1RV), and an HTLV-1 negative T-cell lymphoma (Jurkat) were injected intratibially into NSG mice, and were capable of proliferating and modifying the bone microenvironment. Radiography, mu CT, histopathology, immunohistochemistry, plasma calcium concentrations, and qRT-PCR for several tumor-bone signaling mRNAs were performed. Luciferase-positive ATL-ED bone tumors allowed for in vivo imaging and visualization of bone tumor growth and metastasis over time. ATL-ED and HT-1RV cells caused mixed osteolytic/osteoblastic bone tumors, TL-Oml cells exhibited minimal bone involvement and aggressive local invasion into the adjacent soft tissues, Jurkat cells proliferated within bone marrow and induced minimal bone cell response, and RV-ATL cells caused marked osteolysis. This mouse model revealed important mechanisms of human ATL bone neoplasms and will be useful to investigate biological interactions, potential therapeutic targets, and new bone-targeted agents for the prevention of ATL metastases to bone. | |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) - P01 CA100730 | |
dc.description.sponsorship | Appeared in source as:National Cancer Institute T32 OD010429 Appeared in source as:National Cancer Institute | |
dc.description.sponsorship | Ohio State University Comprehensive Cancer Center | |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA - P30 CA016058 | |
dc.description.sponsorship | Appeared in source as:National Institutes of Health | |
dc.identifier.doi | 10.1016/j.jbo.2019.100257 | |
dc.identifier.issn | 2212-1374 | |
dc.identifier.uri | https://doi.org/10.1016/j.jbo.2019.100257 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2212137419300983 | |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911918/ | |
dc.identifier.uri | https://hdl.handle.net/11452/43411 | |
dc.identifier.volume | 19 | |
dc.identifier.wos | 000506872600001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.journal | Journal of Bone Oncology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Hormone-related protein | |
dc.subject | Leukemia-lymphoma | |
dc.subject | Humoral hypercalcemia | |
dc.subject | Gene-expression | |
dc.subject | Serum-levels | |
dc.subject | Kappa-b | |
dc.subject | Mice | |
dc.subject | Engraftment | |
dc.subject | Patient | |
dc.subject | Cancer | |
dc.subject | Htlv-1 | |
dc.subject | Lymphoma | |
dc.subject | Mouse model | |
dc.subject | Metastasis | |
dc.subject | Bone resorption | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Oncology | |
dc.title | Mouse model recapitulates the phenotypic heterogeneity of human adult T-cell leukemia/lymphoma in bone | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e | |
relation.isAuthorOfPublication.latestForDiscovery | 0181d6a3-f0f7-40e3-9dc8-9dc86a78ac8e |
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