Publication:
Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation

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dc.contributor.authorMeade, Julie
dc.contributor.authorGül, Zülfiye
dc.contributor.authorBağdaş, Deniz
dc.contributor.buuauthorCam, Betül
dc.contributor.buuauthorCinkılıç, Nilüfer
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.departmentBiyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.researcheridAAH-5296-2021
dc.contributor.researcheridCGO-3719-2022
dc.contributor.researcheridDVX-8040-2022
dc.contributor.scopusid56427863700
dc.contributor.scopusid26533892300
dc.contributor.scopusid55664349700
dc.date.accessioned2022-12-19T12:11:21Z
dc.date.available2022-12-19T12:11:21Z
dc.date.issued2020
dc.description.abstractBackground: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.
dc.identifier.citationBağdaş, D. vd. (2020). "Pharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation". Current Neuropharmacology, 18(3), 216-228.
dc.identifier.endpage228
dc.identifier.issn1570-159X
dc.identifier.issn1875-6190
dc.identifier.issue3
dc.identifier.pubmed31631820
dc.identifier.scopus2-s2.0-85079435812
dc.identifier.startpage216
dc.identifier.urihttps://doi.org/10.2174/1570159X17666191021111809
dc.identifier.urihttp://www.eurekaselect.com/article/101699
dc.identifier.urihttp://hdl.handle.net/11452/29959
dc.identifier.volume18
dc.identifier.wos000514651000004
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherBentham Science
dc.relation.collaborationYurt dışı
dc.relation.collaborationYurt içi
dc.relation.journalCurrent Neuropharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChlorogenic
dc.subjectAcid
dc.subjectInflammation
dc.subjectPain
dc.subjectInflammatory
dc.subjectNeuropathic
dc.subjectAntihyperalgesic
dc.subjectAntiallodynic
dc.subjectNF-Kappa B
dc.subjectGated potassium channels
dc.subjectGaba receptor agonists
dc.subjectNitric-oxide synthase
dc.subjectIncuded liver-injury
dc.subjectOxygen species ros
dc.subjectHypericum-perforatum
dc.subjectCaffeic acid
dc.subjectNeuropathic pain
dc.subjectIn-vitro
dc.subjectNeurosciences & neurology
dc.subjectPharmacology & pharmacy
dc.subject.emtreeAntioxidant
dc.subject.emtreeBidens pilosa extract
dc.subject.emtreeCaffeic acid
dc.subject.emtreeCheilanthes farinose extract
dc.subject.emtreeChlorogenic acid
dc.subject.emtreeChlorogenic acid derivative
dc.subject.emtreeCnidium officinale extract
dc.subject.emtreeDrug metabolite
dc.subject.emtreeErycibe obtusifolia extract
dc.subject.emtreeFerulic acid
dc.subject.emtreeHypericum perforatum extract
dc.subject.emtreeIon channel
dc.subject.emtreeMansoa alliacea extract
dc.subject.emtreePlant extract
dc.subject.emtreePorana sinensis extract
dc.subject.emtreeRosae multiflorae extract
dc.subject.emtreeUnclassified drug
dc.subject.emtreeUrtica circularis extract
dc.subject.emtreeAnalgesic agent
dc.subject.emtreeAntiinflammatory agent
dc.subject.emtreeChlorogenic acid
dc.subject.emtreePlant extract
dc.subject.emtreeAntiinflammatory activity
dc.subject.emtreeAntinociception
dc.subject.emtreeArthritis
dc.subject.emtreeChronic pain
dc.subject.emtreeConsensus
dc.subject.emtreeDegenerative disease
dc.subject.emtreeDisease model
dc.subject.emtreeDrug mechanism
dc.subject.emtreeEthnopharmacology
dc.subject.emtreeHuman
dc.subject.emtreeIn vivo study
dc.subject.emtreeInflammation
dc.subject.emtreeInflammatory pain
dc.subject.emtreeNeuropathic pain
dc.subject.emtreeNonhuman
dc.subject.emtreePain
dc.subject.emtreeReview
dc.subject.emtreeRheumatoid arthritis
dc.subject.emtreeAnimal
dc.subject.emtreeChronic pain
dc.subject.emtreeComplication
dc.subject.emtreeEncephalitis
dc.subject.emtreeMetabolism
dc.subject.emtreeSepsis
dc.subject.meshAnalgesics
dc.subject.meshAnimals
dc.subject.meshAnti-inflammatory agents
dc.subject.meshChlorogenic acid
dc.subject.meshChronic pain
dc.subject.meshDisease models
dc.subject.meshAnimal
dc.subject.meshEncephalitis
dc.subject.meshHumans
dc.subject.meshPlant extracts
dc.subject.meshSepsis
dc.subject.scopusAntioxidant; Carlina Oxide; Lonicera
dc.subject.wosNeurosciences
dc.subject.wosPharmacology & pharmacy
dc.titlePharmacologic overview of chlorogenic acid and its metabolites in chronic pain and inflammation
dc.typeArticle
dc.wos.quartileQ1
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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