Publication:
Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: The involvement of cholinergic system

dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridAAH-1448-2021
dc.contributor.researcheridAAC-9702-2019
dc.date.accessioned2021-06-30T12:30:05Z
dc.date.available2021-06-30T12:30:05Z
dc.date.issued2002-05
dc.description.abstractIntracerebroventricular (i.c.v.) administration of CDP-choline (0.25, 0.5, 1 and 2 mumol) induced prompt, dose- and time-dependent increase in blood pressure in normotensive rats. Equimolar dose of CDP-choline (1 mumol; i.c.v.) and choline (1 mumol; i.c.v.) caused similar increases in blood pressure while cytidine (1 mumol; i.c.v.) failed to produce any pressor effect. In haemorrhagic shock, CDPcholine (0.1, 0.25, 0.5 and 1 mumol; i.c.v.) increased blood pressure dose- and time-dependently. The complete reversal of hypotension was observed with the i.c.v. injection of CDP-choline (1 mumol) and choline (1 mumol). Cytidine (1 mumol; i.c.v.) produced small, but significant (P<0.05) increase in blood pressure in haemorrhaged rats. Dose-related bradycardia was observed with the injection of CDP-choline in normotensive rats, but the changes in heart rate were not significantly different (P>0.05) in hypotensive conditions. Choline levels in lateral cerebral ventricle and hypothalamus increased about nine- and five-fold, respectively, after CDP-choline (1 mumol) administration in normotensive rats. In haemorrhagic shock extracellular choline levels in hypothalamus increased sevenfold after an i.c.v. administration of CDP-choline (1 mumol). Hemicholinium-3 (20 mug; i.c.v.), a neuronal high affinity choline uptake blocker, and mecamylamine (50 mug; i.c.v.), nicotinic receptor antagonist, pretreatment abolished the pressor effect of CDP-choline in normal rats. The increase in blood pressure was also attenuated by atropine (10 mug; i.c.v.) pretreatment. Atropine blocked the bradycardic response observed after CDP-choline. In haemorrhaged rats, the pressor effect of CDP-choline was attenuated by hemicholinium-3 and mecamylamine while atropine failed to alter the pressor response to CDP-choline. i.c.v. CDPcholine increased plasma adrenaline and vasopressin levels in normal rats. Haemorrhage, itself, increased plasma catecholamines and vasopressin levels. CDP-choline (1 mumol) produced additional increases in the elevated plasma levels of these hormones. An alpha(1)-adrenoceptor blocker, prazosin (0.5 mg/kg; i.v.), or vasopressin V, receptor antagonist, [beta-mercapto, beta,beta-cyclopenta-methyl-enepropionyl(1), O-Me-Tyr(2)-Arg(8)]-vasopressin (10 mug/kg; i.v.), pretreatments partially blocked the pressor response to CDP-choline (1 mumol; i.c.v.). Simultaneous administration of these two antagonists completely blocked the pressor effect of CDP-choline in haemorrhagic shock. These results show that the exogenous administration of CDPcholine increases blood pressure and reverses hypotension in haemorrhagic shock. In normotensive conditions, increase in blood pressure appears to be due to the activation of both nicotinic and muscarinic central cholinergic receptors through the activation of presynaptic cholinergic mechanisms. In hypotensive rats, activation of nicotinic cholinergic receptors is solely involved in the pressor effect. Increase in plasma vasopressin and adrenaline mediates the pressor response of CDP-choline in both normotensive and hypotensive conditions.
dc.identifier.citationSavcı, V. vd. (2002). "Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system". Naunyn-Schmiedebergs Archives of Pharmakology, 365(5), 388-398.
dc.identifier.endpage398
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue5
dc.identifier.pubmed12012025
dc.identifier.scopus2-s2.0-0036255544
dc.identifier.startpage388
dc.identifier.urihttps://doi.org/10.1007/s00210-002-0531-4
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00210-002-0531-4
dc.identifier.urihttp://hdl.handle.net/11452/20943
dc.identifier.volume365
dc.identifier.wos000176069900008
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.journalNaunyn-Schmiedebergs Archives of Pharmacokogy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCytidine
dc.subjectCdp-choline
dc.subjectCholine
dc.subjectCholinergic
dc.subjectShock
dc.subjectHaemorrhage
dc.subjectVasopressin
dc.subjectAdrenaline
dc.subjectConscıous rats
dc.subjectNicotinic receptors
dc.subjectAcetylcholine-receptors
dc.subjectTyrosine-Hydroxylase
dc.subjectHemorrhagic-shock
dc.subjectBlood-pressure
dc.subjectNeurons
dc.subjectBrain
dc.subjectHippocampal
dc.subjectCiticoine
dc.subjectPharmacology & pharmacy
dc.subject.wosPharmacology & pharmacy
dc.titleCardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: The involvement of cholinergic system
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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