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Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis

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dc.contributor.authorEscribano, Damian
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorJoaquin Ceron, Jose
dc.contributor.authorPardo-Marin, Luis
dc.contributor.authorTorrecillas, Alejandro
dc.contributor.authorMartinez-Subiela, Silvia
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentDahiliye Ana Bilim Dalı
dc.contributor.orcid0000-0001-9836-0749
dc.contributor.researcheridV-5578-2017
dc.contributor.scopusid36437200800
dc.contributor.scopusid35944810500
dc.date.accessioned2022-11-29T07:56:05Z
dc.date.available2022-11-29T07:56:05Z
dc.date.issued2016-10-10
dc.description.abstractThe aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed. APO-A1 was selected and an immunoturbidimetric assay was validated for its measurement in dogs. Significantly decreased concentrations of APO-A1 in dogs with leishmaniosis and a significant increase after a good response to the treatment were observed, suggesting that APO-A1 could be a potential biomarker of treatment monitoring with the advantages of an automated measurement.
dc.description.sponsorshipRobles Chillida foundation
dc.description.sponsorshipProgram for Research Groups of Excellence of the Seneca Foundation - 19894/GERM/15
dc.description.sponsorshipJuan de la Cierva postdoctoral fellowship (Spanish Ministry of Economy and Competitiveness)
dc.identifier.citationEscribano, D. vd. (2016). "Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis". Comparative Immunology Microbiology and Infectious Diseases, 49, 82-87.
dc.identifier.doi10.1016/j.cimid.2016.10.002
dc.identifier.endpage87
dc.identifier.issn0147-9571
dc.identifier.issn1878-1667
dc.identifier.pubmed27865270
dc.identifier.scopus2-s2.0-84993970544
dc.identifier.startpage82
dc.identifier.urihttps://doi.org/10.1016/j.cimid.2016.10.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0147957116300984
dc.identifier.urihttp://hdl.handle.net/11452/29618
dc.identifier.volume49
dc.identifier.wos000390521800011
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalComparative Immunology, Microbiology and Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakTOVAG-2130032
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImmunology
dc.subjectMicrobiology
dc.subjectVeterinary sciences
dc.subjectLeishmaniosis
dc.subjectDogs
dc.subjectApolipoprotein A1
dc.subjectTreatment monitoring
dc.subjectVisceral leishmaniasis
dc.subjectProteins
dc.subjectIdentification
dc.subjectProteomics
dc.subjectDiagnosis
dc.subject.emtreeAlpha 1 antitrypsin
dc.subject.emtreeApolipoprotein A1
dc.subject.emtreeBiological marker
dc.subject.emtreeHaptoglobin
dc.subject.emtreeHemoglobin beta chain
dc.subject.emtreeImmunoglobulin lambda chain
dc.subject.emtreeMeglumine
dc.subject.emtreeRetinol binding protein 4
dc.subject.emtreeVitamin D binding protein
dc.subject.emtreeAllopurinol
dc.subject.emtreeAntiprotozoal agent
dc.subject.emtreeApolipoprotein A1
dc.subject.emtreeMeglumine antimoniate
dc.subject.emtreeOrganometallic compound
dc.subject.emtreeProteome
dc.subject.emtreeArticle
dc.subject.emtreeBlood sampling
dc.subject.emtreeCanine leishmaniasis
dc.subject.emtreeDrug response
dc.subject.emtreeLeishmaniasis
dc.subject.emtreeLimit of detection
dc.subject.emtreeMass spectrometry
dc.subject.emtreeMonitoring
dc.subject.emtreeNonhuman
dc.subject.emtreeProtein blood level
dc.subject.emtreeProtein expression
dc.subject.emtreeProteomics
dc.subject.emtreeTwo dimensional electrophoresis
dc.subject.emtreeValidity
dc.subject.emtreeAnimal
dc.subject.emtreeBlood
dc.subject.emtreeChemistry
dc.subject.emtreeDog
dc.subject.emtreeLeishmaniasis
dc.subject.emtreeTwo dimensional gel electrophoresis
dc.subject.meshAllopurinol
dc.subject.meshAnimals
dc.subject.meshAntiprotozoal agents
dc.subject.meshApolipoprotein A-I
dc.subject.meshBiomarkers
dc.subject.meshDogs
dc.subject.meshElectrophoresis, gel, two-dimensional
dc.subject.meshLeishmaniasis
dc.subject.meshMass spectrometry
dc.subject.meshMeglumine
dc.subject.meshOrganometallic compounds
dc.subject.meshProteome
dc.subject.scopusLeishmania Infantum; Dog; Psychodidae
dc.subject.wosImmunology
dc.subject.wosMicrobiology
dc.subject.wosVeterinary sciences
dc.titleSerum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis
dc.typeArticle
dc.wos.quartileQ4 (Immunology)
dc.wos.quartileQ3 (Microbiology)
dc.wos.quartileQ1 (Veterinary sciences)
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Dahiliye Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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