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Serum pNF-H levels in the first six hours after experimental mild traumatic brain injury in rats

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dc.contributor.authorKaresioglu, E.
dc.contributor.authorCikriklar, H. I.
dc.contributor.authorDurak, V. A.
dc.contributor.authorAydin, B.
dc.contributor.authorArdic, A.
dc.contributor.authorArmagan, E.
dc.contributor.buuauthorKARESİOĞLU, EMİNE
dc.contributor.buuauthorÇIKRIKLAR, HALİL İBRAHİM
dc.contributor.buuauthorDURAK, VAHİDE ASLIHAN
dc.contributor.buuauthorAYDIN, BENGÜL
dc.contributor.buuauthorARDIÇ, ANIL
dc.contributor.buuauthorARMAĞAN, EROL
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAcil Tıp Ana Bilim Dalı
dc.contributor.scopusid57934241300
dc.contributor.scopusid6504065528
dc.contributor.scopusid55792633100
dc.contributor.scopusid58445062100
dc.contributor.scopusid57934555900
dc.date.accessioned2025-05-13T06:40:59Z
dc.date.issued2022-01-01
dc.description.abstractOBJECTIVE: Mild traumatic brain injury (mTBI) cases with a normal CT scanning account for the vast majority of all TBI patients. The aim of this study was to investigate the course of serum Phosphorylated Neurofilament Heavy Chain (pNF-H) levels in the first six hours after trauma in rats in experimental mTBI. MATERIALS AND METHODS: In this experimental animal study, 32 female Sprague-Dawley rats were enrolled equally (n=8) into 3 experimental groups and 1 control group. In experimental groups, animals were exposed to a mTBI with a free fall of 50-gram metal disc from a height of 80 cm. We compared serum pNF-H levels at the 2nd, 4th, and 6th hours after traumatic brain injury in the experimental groups with the control group. RESULTS: Serum pNF-H levels at the 2nd and 4th hours after traumatic brain injury were statistically significantly higher than the control group. Serum pNF-H levels gradually decreased at the 4th and 6th hours compared to the 2nd hour and decreased to a similar level to the control group at the 6th hour after injury. CONCLUSIONS: A high serum pNF-H value, could be used in the diagnosis and management of mTBI patients.
dc.identifier.doi10.26355/eurrev_202210_29873
dc.identifier.endpage6934
dc.identifier.issn1128-3602
dc.identifier.issue19
dc.identifier.scopus2-s2.0-85140227871
dc.identifier.startpage6928
dc.identifier.urihttps://hdl.handle.net/11452/51741
dc.identifier.volume26
dc.indexed.scopusScopus
dc.language.isoen
dc.publisherVerduci Editore
dc.relation.journalEuropean Review for Medical and Pharmacological Sciences
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhosphorylated neurofilament heavy chain
dc.subjectMild traumatic brain injury
dc.subjectEmergency department
dc.titleSerum pNF-H levels in the first six hours after experimental mild traumatic brain injury in rats
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Acil Tıp Ana Bilim Dalı
local.indexed.atScopus
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relation.isAuthorOfPublication78ee6e3b-c9bf-46cd-8b09-951e27cecebc
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relation.isAuthorOfPublication10e0e2a5-9120-45ab-91b7-930ed04c7fd4
relation.isAuthorOfPublication.latestForDiscovery26234427-85ac-4599-9cc9-7cedb8654ceb

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