Maternal serum mannose-binding lectin levels and serum parameters in severe preeclampsia

Abstract

Objective: We have aimed to compare the serum mannose-binding lectin (MBL) levels in severe preeclampsia with those in uncomplicated pregnancies and healthy women and to investigate the correlation with serum biochemical markers.Materials and Methods: This study includes 27 patients with severe preeclampsia (Group 1); 27, with uncomplicated pregnancy (Group 2); and 25 healthy women of reproductive-age (Group 3). We have made complete blood counts and measured the prothrombin time, activated partial thromboplastin time, the international normalized ratio; and the serum levels of urea, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and MBL.Results: The mean serum MBL level was significantly higher (p <= 0.05) in Group 1 than in Groups 2 and 3, while the MBL levels did not differ significantly between Groups 2 and 3 (p>0.05). High MBL level was not correlated with age, blood pressure, complete blood count, haemostatic parameters, and liver and renal functions.Discussion: Serum MBL level increases significantly in severe preeclampsia, but is not correlated with the degree of the severity.