Publication:
Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse

dc.contributor.authorToma, Wisam
dc.contributor.authorKyte, S. Lauren
dc.contributor.authorAlkhlaif, Yasmin
dc.contributor.authorAlsharari, Shakir D.
dc.contributor.authorLichtman, Aron H.
dc.contributor.authorChen, Zhi-Jian
dc.contributor.authorDel fabbro, Egidio
dc.contributor.authorBigbee, John W.
dc.contributor.authorGewirtz, David A.
dc.contributor.authorDamaj, M. Imad
dc.contributor.buuauthorBağdas, Deniz
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentDeney Hayvanları Yetiştirme ve Araştırma Merkezi
dc.contributor.scopusid15062425700
dc.date.accessioned2022-11-03T07:20:10Z
dc.date.available2022-11-03T07:20:10Z
dc.date.issued2017-05-01
dc.description.abstractPaclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer patients. However, paclitaxel and other chemotherapy drugs elicit peripheral nerve fiber dysfunction or degeneration that leads to peripheral neuropathy in a large proportion of cancer patients. Patients receiving chemotherapy also often experience changes in mood, including anxiety and depression. These somatic and affective disorders represent major dose-limiting side effects of chemotherapy. Consequently, the present study was designed to develop a preclinical model of paclitaxel-induced negative affective symptoms in order to identify treatment strategies and their underlying mechanisms of action. Intraperitoneal injections of paclitaxel (8 mg/kg) resulted in the development and maintenance of mechanical and cold allodynia. Carboplatin, another cancer chemotherapeutic drug that is often used in combination with paclitaxel, sensitized mice to the nociceptive effects of paclitaxel. Paclitaxel also induced anxiety-like behavior, as assessed in the novelty suppressed feeding and light/dark box tests. In addition, paclitaxel-treated mice displayed depression-like behavior during the forced swim test and an anhedonia-like state in the sucrose preference test. In summary, paclitaxel produced altered behaviors in assays modeling affective states in C57BL/6J male mice, while increases in nociceptive responses were longer in duration. The characterization of this preclinical model of chemotherapy-induced allodynia and affective symptoms, possibly related to neuropathic pain, provides the basis for determining the mechanism(s) underlying severe side effects elicited by paclitaxel, as well as for predicting the efficacy of potential therapeutic interventions.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA - R01-CA206028
dc.description.sponsorshipVCU Massey Cancer Center
dc.description.sponsorshipNIH-NCI Cancer Center Support Grant - P30 CA016059
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI) - R01CA206028 - P30CA016059
dc.identifier.citationToma, W. vd. (2017). ''Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse''. Neuropharmacology, 117, 305-315.
dc.identifier.endpage315
dc.identifier.issn0028-3908
dc.identifier.issn1873-7064
dc.identifier.pubmed28237807
dc.identifier.scopus2-s2.0-85013744790
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2017.02.020
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0028390817300746
dc.identifier.urihttp://hdl.handle.net/11452/29338
dc.identifier.volume117
dc.identifier.wos000400533800029
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalNephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurosciences & neurology
dc.subjectPharmacology & pharmacy
dc.subjectInduced peripheral neuropathy
dc.subjectQuality of life
dc.subjectBreast cancer
dc.subjectIn vivo
dc.subjectPain
dc.subjectChemotherapy
dc.subjectPrevalence
dc.subjectCisplatin
dc.subjectModel
dc.subjectPhass III
dc.subject.emtreeCarboplatin
dc.subject.emtreePaclitaxel
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCarboplatin
dc.subject.emtreePaclitaxel
dc.subject.emtreeAdult
dc.subject.emtreeAllodynia
dc.subject.emtreeAnhedonia
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeAnxiety
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeDepression
dc.subject.emtreeDose response
dc.subject.emtreeDrug sensitization
dc.subject.emtreeEmotional disorder
dc.subject.emtreeLow drug dose
dc.subject.emtreeMale
dc.subject.emtreeMouse
dc.subject.emtreeMultiple cycle treatment
dc.subject.emtreeNeuropathy
dc.subject.emtreeNociception
dc.subject.emtreeNonhuman
dc.subject.emtreeAnimal
dc.subject.emtreeAnimal behavior
dc.subject.emtreeC57BL mouse
dc.subject.emtreeChemically induced
dc.subject.emtreeDrug effects
dc.subject.emtreeEpidermis
dc.subject.emtreeHyperalgesia
dc.subject.emtreeInnervation
dc.subject.emtreeMotor activity
dc.subject.emtreeNociceptive pain
dc.subject.emtreePathology
dc.subject.emtreeRandomization
dc.subject.meshAnhedonia
dc.subject.meshAntineoplastic agents, phytogenic
dc.subject.meshBehavior
dc.subject.meshCarboplatin
dc.subject.meshDepression
dc.subject.meshEpidermis
dc.subject.meshHyperalgesia
dc.subject.meshMale
dc.subject.meshMice, inbred C57BL
dc.subject.meshMotor activity
dc.subject.meshNociceptive pain
dc.subject.meshPaclitaxel
dc.subject.meshRandom allocation
dc.subject.meshAnxiety
dc.subject.meshAnimals
dc.subject.meshAnimal
dc.subject.scopusEpithelial Mesenchymal Transition; Transcription Factors; Ectoderm
dc.subject.wosNeurosciences
dc.subject.wosPharmacology & pharmacy
dc.titleEffects of paclitaxel on the development of neuropathy and affective behaviors in the mouse
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi
local.indexed.atPubMed
local.indexed.atWOS

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