Publication:
Epigenetic approach to early-onset Parkinson's disease: Low methylation status of SNCA and PARK2 promoter regions

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dc.contributor.authorElibol, Bülent
dc.contributor.authorBora, Ayşe Tokcaer
dc.contributor.authorSaka, Esen
dc.contributor.authorDemirkıran, Meltem
dc.contributor.authorAkbostancı, Cenk
dc.contributor.authorDoğu, Okan
dc.contributor.authorÇolakoğlu, Beril
dc.contributor.authorKenangil, Gülay
dc.contributor.authorKaleagası, Hakan
dc.contributor.buuauthorEryılmaz, Işıl Ezgi
dc.contributor.buuauthorÇeçener, Gulşah
dc.contributor.buuauthorErer, Sevda
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorZarifoğlu, Mehmet
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNöroloji Ana Bilim Dalı
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3316-316X
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridGWV-3548-2022
dc.contributor.researcheridAAP-9988-2020
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridABI-6078-2020
dc.contributor.scopusid57189380840
dc.contributor.scopusid6508156530
dc.contributor.scopusid25635370800
dc.contributor.scopusid55665145000
dc.contributor.scopusid6603411305
dc.contributor.scopusid6602965754
dc.date.accessioned2023-01-02T12:49:56Z
dc.date.available2023-01-02T12:49:56Z
dc.date.issued2017-08-12
dc.description.abstractBackground and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods: The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with EOPD and 52 healthy individuals. Results: The methylation of SNCA and PARK2 promoter regions were significantly lower in EOPD patients compared to the control group (P = 0.013 and P = 0.03, respectively). We also found that the methylation status of the SNCA might be associated with positive family history of PD (P = 0.042). Conclusion: Although it should be supported by further analysis, based on the results of the present study, the methylation status of SNCA and PARK2 genes might contribute to EOPD pathogenesis.
dc.identifier.citationEryılmaz, I. E. vd. (2017). ''Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions''. Neurological Research, 39(11), 965-972.
dc.identifier.endpage972
dc.identifier.issn0161-6412
dc.identifier.issue11
dc.identifier.pubmed28830306
dc.identifier.scopus2-s2.0-85028553453
dc.identifier.startpage965
dc.identifier.urihttps://doi.org/10.1080/01616412.2017.1368141
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01616412.2017.1368141
dc.identifier.uri1743-1328
dc.identifier.urihttp://hdl.handle.net/11452/30224
dc.identifier.volume39
dc.identifier.wos000414052900004
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.bapKUAP(T)-2013/43
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectEarly-onset parkinson’s disease
dc.subjectEpigenetic
dc.subjectMethylation
dc.subjectPARK2
dc.subjectSNCA
dc.subjectAlpha-synuclein
dc.subjectLeukocyte dna
dc.subjectGene
dc.subjectMutations
dc.subjectExpression
dc.subject.emtreeAlpha synuclein
dc.subject.emtreeBisulfite
dc.subject.emtreeLevodopa
dc.subject.emtreeParkin 2
dc.subject.emtreeUbiquitin protein ligase E3
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAlpha synuclein
dc.subject.emtreeParkin
dc.subject.emtreeSNCA protein, human
dc.subject.emtreeUbiquitin protein ligase
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeCpG island
dc.subject.emtreeDisease duration
dc.subject.emtreeDNA methylation
dc.subject.emtreeDNA sequence
dc.subject.emtreeEpigenetics
dc.subject.emtreeExon
dc.subject.emtreeFemale
dc.subject.emtreeGene
dc.subject.emtreeGenetic association
dc.subject.emtreeHuman
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeMiddle aged
dc.subject.emtreeMissense mutation
dc.subject.emtreeNonsense mutation
dc.subject.emtreePARK2 gene
dc.subject.emtreeParkinson disease
dc.subject.emtreePolymerase chain reaction
dc.subject.emtreePromoter region
dc.subject.emtreeSNCA gene
dc.subject.emtreeUnified parkinson disease rating scale
dc.subject.emtreeGenetic epigenesis
dc.subject.emtreeGenetic predisposition
dc.subject.emtreeGenetics
dc.subject.emtreeMetabolism
dc.subject.emtreeOnset age
dc.subject.emtreeParkinson disease
dc.subject.emtreePedigree
dc.subject.meshAge of onset
dc.subject.meshalpha-synuclein
dc.subject.meshCpG islands
dc.subject.meshEpigenesis, genetic
dc.subject.meshFemale
dc.subject.meshGenetic predisposition to disease
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshParkinson disease
dc.subject.meshPedigree
dc.subject.meshPromoter regions
dc.subject.meshGenetic
dc.subject.meshUbiquitin-protein ligases
dc.subject.meshDNA methylation
dc.subject.scopusPTEN-induced Putative Kinase; Parkin Protein; Protein Deglycase DJ-1
dc.subject.wosClinical neurology
dc.subject.wosNeurosciences
dc.titleEpigenetic approach to early-onset Parkinson's disease: Low methylation status of SNCA and PARK2 promoter regions
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Nöroloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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