Publication: Results of cisplatin, adriamycin and etoposide chemotherapy in patients with recurrent and metastatic endometrial cancer
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Bilgin, Tufan
Ozan, Hakan
Kara, H. Filiz
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MRE Press
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Abstract
The efficacy of the combination treatment of cisplatin, adriamycin and etoposide were retrospectively evaluated in 26 recurrent or metastatic endometrial cancer patients. One hundred and twenty-three treatment courses were observed. Patients received 20 mg/m(2) cisplatin and 80 mg/m(2) etoposide by continuous IV infusion for three days and adriamycin 40 mg/m(2) IV the second day. Treatment courses were repeated every four weeks. Megestrol acetate, 160 mg/day, was added in six patients who had positive progesterone receptors. Ten (38.5%) women had complete and three (11.5%) patients had partial response with an overall response rate of 50%. Median follow-up was 24 months. Surviving patients were alive for four months and six years. Toxicity was mainly hematological and gastrointestinal ulcerations and stomatitis were also observed.
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Oncology, Obstetrics and gynecology, Endometrial cancer, Chemotherapy, Cisplatin, Adriamycin, Etoposide, Medroxyprogesterone acetate, Adenocarcinoma, Cyclophosphamide, 5-Fluorouracil, Doxorubicin, Paclitaxel, Epirubicin, Carcinoma, Regimen
Citation
Bilgin, T. vd. (2004). “Results of cisplatin, adriamycin and etoposide chemotherapy in patients with recurrent and metastatic endometrial cancer”. European Journal of Gynaecological Oncology, 25(3), 379-380.