Publication: Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells - An immuno electron microscopic study
Date
Authors
Çavuşoğlu, İlkin
Authors
Şeftalioğlu, Aysel
Karakuş, Sema
Dündar, Semra
Can, Belgin
Erdemli, Esra
Irmak, Mehmet Kemal
Öztaş, Emin
Korkmaz, Cem
Yazar, Fatih
Advisor
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Taylor and Francis
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Abstract
Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known; its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.
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Keywords
Oncology, Heparan-sulfate proteoglycan, Acute lymphoblastic-leukemia, Bone-marrow, Stroma, Molecular-cloning, Migration, Adhesion, Biopsy, Bone, Cells, Electron microscopy, Myeloblastic leukemia cells, Tumors
Citation
Şeftalioğlu, A. vd. (2003). “Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells - An immuno electron microscopic study”. Acta Oncologica, 42(1), 71-74.