Publication: DPYD c.1905+1G>A promotes fluoropyrimidine-induced anemia, a prognostic factor in disease-free survival, in colorectal cancer
dc.contributor.author | Deligönül, Adem | |
dc.contributor.author | Aksoy, Seçil | |
dc.contributor.author | Tezcan, Gülçin | |
dc.contributor.author | Tunca, Berrin | |
dc.contributor.author | Kanat, Özkan | |
dc.contributor.author | Çubukcu, Erdem | |
dc.contributor.author | Yılmazlar, Tuncay | |
dc.contributor.author | Öztürk, Ersin | |
dc.contributor.author | Egeli, Ünal | |
dc.contributor.author | Çeçener, Gülşah | |
dc.contributor.author | Alemdar, Adem | |
dc.contributor.author | Evrensel, Türkkan | |
dc.contributor.buuauthor | DELİGÖNÜL, ADEM | |
dc.contributor.buuauthor | AKSOY, SEÇİL | |
dc.contributor.buuauthor | TEZCAN, GÜLÇİN | |
dc.contributor.buuauthor | TUNCA, BERRİN | |
dc.contributor.buuauthor | Kanat, Özka | |
dc.contributor.buuauthor | ÇUBUKÇU, ERDEM | |
dc.contributor.buuauthor | YILMAZLAR, AHMET TUNCAY | |
dc.contributor.buuauthor | EGELİ, ÜNAL | |
dc.contributor.buuauthor | ÇEÇENER, GÜLŞAH | |
dc.contributor.buuauthor | ALEMDAR, ADEM | |
dc.contributor.buuauthor | EVRENSEL, TÜRKKAN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Diş Hekimliği Fakültesi/Temel Bilimler Bölümü. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü. | |
dc.contributor.orcid | 0000-0002-6400-4911 | |
dc.contributor.orcid | 0000-0002-5956-8755 | |
dc.contributor.orcid | 0000-0002-1619-6680 | |
dc.contributor.orcid | 0000-0001-8593-5101 | |
dc.contributor.orcid | 0000-0001-7904-883X | |
dc.contributor.orcid | 0000-0002-3820-424X | |
dc.contributor.researcherid | HIZ-7332-2022 | |
dc.contributor.researcherid | AAH-1420-2021 | |
dc.contributor.researcherid | AAH-3843-2020 | |
dc.contributor.researcherid | ESM-4544-2022 | |
dc.contributor.researcherid | JDG-0330-2023 | |
dc.contributor.researcherid | ABI-6078-2020 | |
dc.contributor.researcherid | CYM-0930-2022 | |
dc.contributor.researcherid | ETP-1691-2022 | |
dc.contributor.researcherid | CKK-3621-2022 | |
dc.contributor.researcherid | AAP-9988-2020 | |
dc.contributor.researcherid | EXZ-0745-2022 | |
dc.date.accessioned | 2024-07-01T12:43:56Z | |
dc.date.available | 2024-07-01T12:43:56Z | |
dc.date.issued | 2021-04-01 | |
dc.description.abstract | Background and Aim: In 10-30% of colorectal cancer (CRC) patients, toxic reactions occur after fluoropyrimidine-based chemotherapy. A dihydropyridine dehydrogenase (DPYD) gene variant, c.1905 + 1G>A, leads to intolerance to fluoropyrimidines. Due to the low frequency of this variant in many populations, the prevalence of fluoropyrimidine-induced hematologic side effects in CRC patients with the c.1905 + 1G>A variant is unclear. In this study, we investigated the prevalence of the DPYD c.1905 + 1 variants in a Turkish CRC cohort and the potential effects of these variants on fluoropyrimidine-induced hematologic side effects.Materials and Methods: The DPYD c.1905 + 1 variant was genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis and confirmed by Sanger sequencing in peripheral blood samples of 100 CRC patients who received fluoropyrimidine-based chemotherapy and 60 healthy volunteers. The association of c.1905 + 1 variants with susceptibility to hematologic side effects was evaluated.Results: The DPYD c.1905 + 1G>A variant was more common in the CRC group than in the healthy control group (p = 0.001). The presence of the c.1905 + 1G>A variant was associated with thrombocytopenia (p = 0.039) and anemia (p = 0.035). CRC patients with fluoropyrimidine-induced anemia had shorter disease-free survival than CRC patients without fluoropyrimidine-induced anemia (p = 0.0009).Conclusions: Before administering fluoropyrimidine-based chemotherapy, genetic screening for the DPYD c.1905 + 1G>A variant should be performed with the aim of preventing anemia and anemia-induced complications in CRC patients. | |
dc.identifier.doi | 10.1089/gtmb.2020.0285 | |
dc.identifier.endpage | 283 | |
dc.identifier.issn | 1945-0265 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 276 | |
dc.identifier.uri | https://doi.org/10.1089/gtmb.2020.0285 | |
dc.identifier.uri | https://www.liebertpub.com/doi/10.1089/gtmb.2020.0285 | |
dc.identifier.uri | https://hdl.handle.net/11452/42666 | |
dc.identifier.volume | 25 | |
dc.identifier.wos | 000641538600004 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Mary Ann Liebert, Inc | |
dc.relation.journal | Genetic Testing and Molecular Biomarkers | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | DPYD c.1905+1G > A | |
dc.subject | Fluoropyrimidine | |
dc.subject | Anemia | |
dc.subject | Colorectal cancer | |
dc.subject | Biochemistry & molecular biology | |
dc.subject | Genetics & heredity | |
dc.title | DPYD c.1905+1G>A promotes fluoropyrimidine-induced anemia, a prognostic factor in disease-free survival, in colorectal cancer | |
dc.type | Article | |
dspace.entity.type | Publication | |
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