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Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder

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dc.contributor.authorAlmacıoğlu, M. L.
dc.contributor.buuauthorArmaǧan, Erol
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorKöse, Ataman
dc.contributor.buuauthorKarkucak, Mutlu
dc.contributor.buuauthorKöksal, Özlem
dc.contributor.buuauthorGörükmez, Orhan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Genetik Ana Bilim Dalı
dc.contributor.departmentAcil Tıp Ana Bilim Dalı
dc.contributor.orcid0000-0003-2271-5659
dc.contributor.researcheridL-7334-2015
dc.contributor.researcheridAAM-7896-2020
dc.contributor.researcheridAAH-8846-2021
dc.contributor.researcheridABI-5648-2022
dc.contributor.researcheridAAK-8332-2020
dc.contributor.scopusid6506464232
dc.contributor.scopusid6602802424
dc.contributor.scopusid15755792500
dc.contributor.scopusid35388323500
dc.contributor.scopusid23389880200
dc.contributor.scopusid56681045900
dc.date.accessioned2024-01-09T06:35:41Z
dc.date.available2024-01-09T06:35:41Z
dc.date.issued2013
dc.description.abstractAlterations in catechol-O-methyltransferase (COMT) activity are involved in various types of neurological disorders. We examined a possible association between the COMT Val158Met polymorphism and conversion disorder in a study of 48 patients with conversion disorder and 48 control patients. In the conversion disorder group, 31 patients were Val/Met heterozygotes, 15 patients were Val/Val homozygotes and 2 patients were Met/Met homozygotes. In the control group, 32 patients were Val/Met heterozygotes and 16 patients were Val/Val homozygotes. There was no significant difference between the groups. We conclude that the COMT Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
dc.identifier.citationArmağan, E. (2013). “Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder”. Genetics and Molecular Research, 12(1), 852-858.
dc.identifier.doi10.4238/2013.March.19.1
dc.identifier.endpage858
dc.identifier.issn1676-5680
dc.identifier.issue1
dc.identifier.pubmed23613193
dc.identifier.scopus2-s2.0-84884403737
dc.identifier.startpage852
dc.identifier.urihttps://doi.org/10.4238/2013.March.19.1
dc.identifier.urihttps://hdl.handle.net/11452/38862
dc.identifier.volume12
dc.identifier.wos000318864400092
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFunpec-Editora
dc.relation.collaborationSanayi işbirliği
dc.relation.journalGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemistry & molecular biology
dc.subjectGenetics & heredity
dc.subjectCOMT
dc.subjectVal158Met genotype
dc.subjectConversion disorder
dc.subjectMethyltransferase gene
dc.subjectBipolar disorder
dc.subjectConduct disorder
dc.subjectEnzyme-activity
dc.subjectCatechol
dc.subjectPolymorphism
dc.subjectAssociation
dc.subjectAttention
dc.subjectAdhd
dc.subject.emtreeCatechol methyltransferase
dc.subject.emtreeCatechol methyltransferase
dc.subject.emtreeAdolescent
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeArticle
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeConversion disorder
dc.subject.emtreeFemale
dc.subject.emtreeGenetic association
dc.subject.emtreeGenetic polymorphism
dc.subject.emtreeGenetic risk
dc.subject.emtreeGenotype
dc.subject.emtreeHeterozygote
dc.subject.emtreeHomozygote
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeTurkey (republic)
dc.subject.emtreeAmino acid substitution
dc.subject.emtreeChi square distribution
dc.subject.emtreeEnzymology
dc.subject.emtreeGene frequency
dc.subject.emtreeGenetic polymorphism
dc.subject.emtreeGenetic predisposition
dc.subject.emtreeGenetics
dc.subject.emtreeMiddle aged
dc.subject.emtreeRisk factor
dc.subject.emtreeVery elderly
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAmino acid substitution
dc.subject.meshCatechol o-methyltransferase
dc.subject.meshChi-square distribution
dc.subject.meshConversion disorder
dc.subject.meshFemale
dc.subject.meshGene frequency
dc.subject.meshGenetic predisposition to disease
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshPolymorphism, genetic
dc.subject.meshRisk factors
dc.subject.meshTurkey
dc.subject.meshYoung adult
dc.subject.scopusCatechol Methyltransferase; Homozygote; Polymorphism
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosGenetics & heredity
dc.titleCathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Acil Tıp Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atScopus

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