Publication:
Improvement of cross-linked alginate hydrogel microparticles loaded with galangin-β-cyclodextrin complex by response surface methodology

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dc.contributor.buuauthorŞAHİN, SALİHA
dc.contributor.buuauthorPatir, Ilkyaz
dc.contributor.buuauthorAYBASTIER, ÖNDER
dc.contributor.buuauthorDorken, Eftal Alp
dc.contributor.departmentKimya Ana Bilim Dalı.
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.orcid0000-0002-0380-1992
dc.contributor.researcheridX-4621-2018
dc.date.accessioned2025-02-06T06:02:35Z
dc.date.available2025-02-06T06:02:35Z
dc.date.issued2024-01-21
dc.description.abstractGalangin is a phenolic compound with antioxidant and anti-tyrosinase activity, which makes it highly useful in cosmetics and medicine. However, the poor solubility of galangin in water limits its usefulness in these areas. This study it is aimed to increase the solubility of galangin in water by encapsulation method. Therefore, in this study, ethanolic and methanolic extracts were obtained from Alpinia officinarum Hance, and the phenolic compound profile and content of the extracts were determined by HPLC-DAD. Galangin was purified and fractionated from Alpinia officinarum Hance extracts by column chromatography. Galangin was encapsulated with beta-cyclodextrin, and galangin-beta-cyclodextrin loaded alginate hydrogel microparticles were developed. The central composite design-response surface methodology was used to develop galangin-beta-cyclodextrin loaded alginate hydrogel microparticles under optimum conditions with maximum galangin release. The encapsulation efficiency and release of galangin in galangin-beta-cyclodextrin loaded alginate hydrogel microparticles developed under optimum conditions were characterized by HPLC-DAD, surface morphology by SEM, and structural properties by FTIR.
dc.identifier.doi10.1007/s10924-023-03155-8
dc.identifier.endpage3325
dc.identifier.issn1566-2543
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85182624381
dc.identifier.startpage3313
dc.identifier.urihttps://doi.org/10.1007/s10924-023-03155-8
dc.identifier.urihttps://hdl.handle.net/11452/50133
dc.identifier.volume32
dc.identifier.wos001145851700003
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalJournal Of Polymers And The Environment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUltrasonic-assisted extraction
dc.subjectAntioxidant compounds
dc.subjectIn-vitro
dc.subjectOptimization
dc.subjectSolubility
dc.subjectDelivery
dc.subjectSystem
dc.subjectVivo
dc.subjectHydrogel
dc.subjectOptimization
dc.subjectMicroencapsulation
dc.subjectAlpinia officinarum
dc.subjectGalangin
dc.subjectScience & technology
dc.subjectTechnology
dc.subjectPhysical sciences
dc.subjectEngineering, environmental
dc.subjectPolymer science
dc.subjectEngineering
dc.titleImprovement of cross-linked alginate hydrogel microparticles loaded with galangin-β-cyclodextrin complex by response surface methodology
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Ana Bilim Dalı.
local.indexed.atWOS
local.indexed.atScopus
relation.isAuthorOfPublication4b87bb21-e6b9-4caf-a469-4b4fad49f199
relation.isAuthorOfPublication875c0dc3-9c4b-47a6-8052-c7f44f84fc9b
relation.isAuthorOfPublication.latestForDiscovery4b87bb21-e6b9-4caf-a469-4b4fad49f199

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