Publication:
Lack of prognostic significance of adiponectin immunohistochemical expression in patients with triplenegative breast cancer

dc.contributor.authorÇubukçu, Erdem
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorKanat, Özkan
dc.contributor.authorKabul, Selva
dc.contributor.authorCanhoroz, Mustafa
dc.contributor.authorAvcı, Nilüfer
dc.contributor.authorHartavi, Mustafa
dc.contributor.authorDeligönül, Adem
dc.contributor.authorÇubukçu, Sinem
dc.contributor.authorManavoğlu, Osman
dc.contributor.buuauthorÇUBUKÇU, ERDEM
dc.contributor.buuauthorÖlmez, Ömer Fatih
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorKABUL, SELVA
dc.contributor.buuauthorCanhoroz, Mustafa
dc.contributor.buuauthorAvcı, Nilüfer
dc.contributor.buuauthorHartavi, Mustafa
dc.contributor.buuauthorDELİGÖNÜL, ADEM
dc.contributor.buuauthorÇUBUKÇU, SİNEM
dc.contributor.buuauthorManavoğlu, Osman
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.researcheridETP-1691-2022
dc.contributor.researcheridDJG-4827-2022
dc.contributor.researcheridCYM-0930-2022
dc.contributor.researcheridCAH-9737-2022
dc.contributor.researcheridCJW-6018-2022
dc.contributor.researcheridCCT-7946-2022
dc.contributor.researcheridCUI-5353-2022
dc.contributor.researcheridESM-4544-2022
dc.contributor.researcheridJJB-0254-2023
dc.contributor.researcheridFLP-9613-2022
dc.date.accessioned2024-11-21T11:23:04Z
dc.date.available2024-11-21T11:23:04Z
dc.date.issued2014-01-01
dc.description.abstractIntroduction: Triple-negative breast cancers (TNBCs) -which lack the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2)-have no established markers that can be used for prognostic stratification. As adiponectin has been previously implicated in a more aggressive phenotype of primary breast cancer, we explored the relation between adiponectin immunohistochemical expression and prognosis in TNBCs.Material and methods: Immunohistochemical staining for adiponectin was performed in 38 TNBC patients. Disease-free survival (DFS) and overall survival (OS) served as the main outcome measures.Results: Of the 38 TNBC patients, 18 (47%) had negative and 20 (53%) positive adiponectin immunohistochemical expression. We did not find any significant association between adipo-nectin immunohistochemical expression and the baseline characteristics. In addition, there were no associations between adiponectin immunohistochemical expression and prognosis.Conclusions: Although our results suggest that adiponectin immunohistochemical expression is not of prognostic significance in TNBCs, further studies are warranted to determine the role of this adipokine in breast cancer biology.
dc.identifier.doi10.5114/wo.2014.40454
dc.identifier.endpage38
dc.identifier.issn1428-2526
dc.identifier.issue1
dc.identifier.startpage34
dc.identifier.urihttps://doi.org/10.5114/wo.2014.40454
dc.identifier.urihttps://www.termedia.pl/Lack-of-prognostic-significance-of-adiponectin-immunohistochemical-expression-in-patients-with-triple-negative-breast-cancer,3,22210,0,1.html
dc.identifier.urihttps://hdl.handle.net/11452/48286
dc.identifier.volume18
dc.identifier.wos000422070400006
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.journalWspolczesna Onkologia-Contemporary Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTriple-negative breast cancer
dc.subjectAdiponectin
dc.subjectImmunohistochemistry
dc.subjectPrognosis
dc.subjectOncology
dc.titleLack of prognostic significance of adiponectin immunohistochemical expression in patients with triplenegative breast cancer
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Onkoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/İç Hastalıkları Ana Bilim Dalı
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relation.isAuthorOfPublication76775155-c27b-4421-bb7b-b154db42aac3
relation.isAuthorOfPublicationedfc19d5-ce9e-4fbd-8a24-07492003c264
relation.isAuthorOfPublication375ef438-7ff8-4a42-97a4-74096fac117f
relation.isAuthorOfPublication.latestForDiscoveryf971677f-09c5-4463-bf01-3c6341fbe5f7

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