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Variants of sars-cov-2, their effects on infection, transmission and neutralization by vaccine induced antibodies

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dc.contributor.authorWahid, M.
dc.contributor.authorJawed, A.
dc.contributor.authorMandal, R. K.
dc.contributor.authorDailah, H. G.
dc.contributor.authorJanahi, E. M.
dc.contributor.authorDhama, K.
dc.contributor.authorSomvanshi, P.
dc.contributor.buuauthorHaque, S.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi.
dc.contributor.orcid0000-0001-7068-8769
dc.contributor.orcid0000-0001-6206-1413
dc.contributor.orcid0000-0001-7991-0151
dc.contributor.orcid0000-0001-7469-4752
dc.contributor.orcid0000-0003-1214-9374
dc.contributor.orcid0000-0002-2989-121X
dc.contributor.researcheridAAR-6999-2021
dc.contributor.researcheridB-7852-2015
dc.date.accessioned2024-06-25T13:34:57Z
dc.date.available2024-06-25T13:34:57Z
dc.date.issued2021-01-01
dc.description.abstractOBJECTIVE: The current study reviewed Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) variants for their effects on infection, transmission and neutralization by vaccine-induced antibodies.MATERIALS AND METHODS: The research articles for the current study were searched over PubMed, Google Scholar, EMBASE and Web of Science online databases. The keywords used were: [("SARS-CoV-2" OR "COVID-19") AND ("mutation" OR "variant") AND ("death" OR "hospitalization" OR "infection" OR "transmission") AND ("antibody" OR "neutralize" OR "vaccine")]. A total of 333 research articles were retrieved through online-database search. These articles were further scrutinized for their relevancy. Additionally, searches were performed to find the latest relevant information over Google search engine and relevant news browsers. Finally, around 35 germane articles were considered for scripting the current report.RESULTS: The mutations have changed amino acids at key positions in spike protein viz. S477N, E484K, 0677H, E484Q, L452R, K417T, K417N and N501Y. These mutations are relevant for different characteristics and are present in newly evolved strains of SARS-CoV-2 like E484K in B.1.526, B.1.525, P.2, B.1.1.7, P.1 and B.1.351. Mutations have increased the immune escape potential leading to 3.5-6.5-folds decrease in neutralization of antibodies (Pfizer and Moderna vaccines). The variant, B.1.617 circulating in India and many other countries (double variant) having E4840 and L452R mutations, has raised the infection rate and decreased the neutralization capacity of the vaccine-induced antibodies. Deadly K417N+E484K+N501Y triplet mutations found in B.1.351 and P.1 have increased the transmission ability of these strains by 50% leading to greater COVID-19 hospitalization, ICU admissions and deaths.CONCLUSIONS: The new SARS-CoV-2 variants have compromised the neutralization potential of the currently used vaccines, but still, they have considerable efficacy to reduce infection and mortality.[GRAPHICS].
dc.identifier.doi10.26355/eurrev_202109_26805
dc.identifier.endpage5864
dc.identifier.issn1128-3602
dc.identifier.issue18
dc.identifier.startpage5857
dc.identifier.urihttps://doi.org/10.26355/eurrev_202109_26805
dc.identifier.urihttps://hdl.handle.net/11452/42386
dc.identifier.volume25
dc.identifier.wos000705057500031
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.journalEuropean Review For Medical And Pharmacological Sciences
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSars-cov-2
dc.subjectCovid-19
dc.subjectVariants
dc.subjectTransmission
dc.subjectVirulence
dc.subjectNeutralization
dc.subjectAntibodies
dc.subjectVaccines
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPharmacology & pharmacy
dc.subjectPharmacology & pharmacy
dc.titleVariants of sars-cov-2, their effects on infection, transmission and neutralization by vaccine induced antibodies
dc.typeArticle
dspace.entity.typePublication

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