Publication:
Biofilm formation and resistance to fungicides in clinically relevant members of the fungal genus fusarium

dc.contributor.authorSav, Hafize
dc.contributor.authorRafati, Haleh
dc.contributor.authorÖz, Yasemin
dc.contributor.authorDalyan-Cilo, Burcu
dc.contributor.authorMohammadi, Faezeh
dc.contributor.authorİlkit, Macit
dc.contributor.authorvan Diepeningen, Anne D.
dc.contributor.authorSeyedmousavi, Seyedmojtaba
dc.contributor.buuauthorEner, Beyza
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentMikrobiyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-4803-8206
dc.contributor.researcheridAAG-8523-2021
dc.contributor.scopusid15053025300
dc.date.accessioned2024-03-20T08:20:03Z
dc.date.available2024-03-20T08:20:03Z
dc.date.issued2018-01-16
dc.description.abstractClinically relevant members of the fungal genus, Fusarium, exhibit an extraordinary genetic diversity and cause a wide spectrum of infections in both healthy individuals and immunocompromised patients. Generally, Fusarium species are intrinsically resistant to all systemic antifungals. We investigated whether the presence or absence of the ability to produce biofilms across and within Fusarium species complexes is linked to higher resistance against antifungals. A collection of 41 Fusarium strains, obtained from 38 patients with superficial and systemic infections, and three infected crops, were tested, including 25 species within the Fusarium fujikuroi species complex, 14 from the Fusarium solani species complex (FSSC), one Fusarium dimerum species complex, and one Fusarium oxysporum species complex isolate. Of all isolates tested, only seven strains from two species of FSSC, five F. petroliphilum and two F. keratoplasticum strains, recovered from blood, nail scrapings, and nasal biopsy samples, could produce biofilms under the tested conditions. In the liquid culture tested, sessile biofilm-forming Fusarium strains exhibited elevated minimum inhibitory concentrations (MICs) for amphotericin B, voriconazole, and posaconazole, compared to their planktonic counterparts, indicating that the ability to form biofilm may significantly increase resistance. Collectively, this suggests that once a surface adherent biofilm has been established, therapies designed to kill planktonic cells of Fusarium are ineffective.
dc.identifier.citationSav, H. vd. (2018). ''Biofilm formation and resistance to fungicides in clinically relevant members of the fungal genus fusarium''. Journal of Fungi, 4(1), Special Issue SI.
dc.identifier.doihttps://doi.org/10.3390/jof4010016
dc.identifier.issn2309-608X
dc.identifier.issue1, Special Issue SI
dc.identifier.pubmed29371509
dc.identifier.scopus2-s2.0-85056793860
dc.identifier.urihttps://www.mdpi.com/2309-608X/4/1/16
dc.identifier.urihttps://hdl.handle.net/11452/40516
dc.identifier.volume4
dc.identifier.wos000451382800005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherMDPI
dc.relation.collaborationYurt dışı
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalJournal of Fungi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMicrobiology
dc.subjectMycology
dc.subjectBiofilms
dc.subjectFusarium solani species complex
dc.subjectFusarium petroliphilum
dc.subjectFusarium keratoplasticum
dc.subjectAntifungal resistance
dc.subjectCandida-albicans biofilms
dc.subjectAntifungal susceptibility
dc.subjectKeratitis
dc.subjectVoriconazole
dc.subjectDiversity
dc.subjectComplex
dc.subjectMechanism
dc.subjectInfection
dc.subjectOutbreak
dc.subject.scopusCandida Albicans; Micafungin; Antifungal Agents
dc.subject.wosMicrobiology
dc.subject.wosMycology
dc.titleBiofilm formation and resistance to fungicides in clinically relevant members of the fungal genus fusarium
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Mikrobiyoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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