Publication:
Association of b7-h4 gene polymorphisms in urothelial bladder cancer

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dc.contributor.authorÖzgöz, Asuman
dc.contributor.authorŞamlı, Murat
dc.contributor.authorŞahin, Ahmet
dc.contributor.authorİnce, Ümit
dc.contributor.authorSağlıcan, Yeşim
dc.contributor.buuauthorDinçel, Deniz
dc.contributor.buuauthorBalcı, Faruk
dc.contributor.buuauthorŞamlı, Hale
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentGenetik Ana Bilim Dalı
dc.contributor.orcid0000-0002-8015-9032
dc.contributor.researcheridAAH-6192-2021
dc.contributor.researcheridAAH-6488-2021
dc.contributor.scopusid56607385000
dc.contributor.scopusid16062981700
dc.contributor.scopusid6507670789
dc.date.accessioned2023-01-31T08:45:14Z
dc.date.available2023-01-31T08:45:14Z
dc.date.issued2016-07-07
dc.description.abstractBackground/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
dc.identifier.citationÖzgöz, A. vd. (2017). ''Association of b7-h4 gene polymorphisms in urothelial bladder cancer''. Turkish Journal of Medical Sciences, 47(2), 443-446.
dc.identifier.endpage446
dc.identifier.issn1300-0144
dc.identifier.issue2
dc.identifier.pubmed28425229
dc.identifier.scopus2-s2.0-85018778719
dc.identifier.startpage443
dc.identifier.urihttps://doi.org/10.3906/sag-1603-54
dc.identifier.uri1303-6165
dc.identifier.urihttps://journals.tubitak.gov.tr/medical/vol47/iss2/12/
dc.identifier.urihttp://hdl.handle.net/11452/30737
dc.identifier.volume47
dc.identifier.wos000399829700012
dc.indexed.scopusScopus
dc.indexed.trdizinTrDizin
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.bapOUAP(V) - 2013 /3
dc.relation.collaborationYurt içi
dc.relation.journalTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & internal medicine
dc.subjectBladder cancer
dc.subjectPolymorphism
dc.subjectB7-H4 gene
dc.subjectT-cell-activation
dc.subjectB7 family-mem
dc.subjectBerbreast-cancer
dc.subjectImmunity
dc.subjectExpression
dc.subjectCostimulation
dc.subjectMolecules
dc.subjectLigands
dc.subject.emtreeTumor marker
dc.subject.emtreeV set domain containing T cell activation inhibitor 1
dc.subject.emtreeVTCN1 protein, human
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeB7 H4 gene
dc.subject.emtreeCancer diagnosis
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeGene
dc.subject.emtreeGene frequency
dc.subject.emtreeGenetic association
dc.subject.emtreeGenotype
dc.subject.emtreeHuman
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeMiddle aged
dc.subject.emtreePolymerase chain reaction
dc.subject.emtreeRestriction fragment length polymorphism
dc.subject.emtreeSingle nucleotide polymorphism
dc.subject.emtreeSmoking
dc.subject.emtreeTransitional cell carcinoma
dc.subject.emtreeAged
dc.subject.emtreeBladder tumor
dc.subject.emtreeGenetic association study
dc.subject.emtreeGenetics
dc.subject.emtreePathology
dc.subject.emtreePhysiology
dc.subject.emtreePredictive value
dc.subject.emtreeReal time polymerase chain reaction
dc.subject.emtreeSingle nucleotide polymorphism
dc.subject.emtreeUrothelium
dc.subject.meshAged
dc.subject.meshBiomarkers, tumor
dc.subject.meshFemale
dc.subject.meshGene frequency
dc.subject.meshGenetic association studies
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshPolymorphism, single nucleotide
dc.subject.meshPredictive value of tests
dc.subject.meshReal-time polymerase chain reaction
dc.subject.meshUrinary bladder neoplasms
dc.subject.meshUrothelium
dc.subject.meshV-set domain-containing T-cell activation inhibitor 1
dc.subject.scopusB7 Antigens; Tumor Escape; Cancer
dc.subject.wosMedicine, general & internal
dc.titleAssociation of b7-h4 gene polymorphisms in urothelial bladder cancer
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Genetik Ana Bilim Dalı
local.indexed.atTrDizin
local.indexed.atWOS
local.indexed.atScopus

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