Publication:
May hemocytometer parameters be a biomarker in distinguishing between adrenal adenomas and carcinomas and in prognosis of adrenocortical carcinomas?

dc.contributor.authorŞişman, Pınar
dc.contributor.buuauthorBiçer, Buket
dc.contributor.buuauthorGül, Özen
dc.contributor.buuauthorCander, Soner
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorSaraydaroğlu, Özlem
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentEndokrinoloji ve Metabolizma Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.orcid0000-0001-6303-7896
dc.contributor.orcid0000-0003-4510-6282
dc.contributor.orcid0000-0002-4127-9656
dc.contributor.orcid0000-0003-2399-6608
dc.contributor.researcheridAAI-1005-2021
dc.contributor.researcheridAAJ-6536-2021
dc.contributor.researcheridAAH-8861-2021
dc.contributor.researcheridAAH-9701-2021
dc.contributor.scopusid57220581517
dc.contributor.scopusid26040787100
dc.contributor.scopusid25027068600
dc.contributor.scopusid6701485882
dc.contributor.scopusid15074395500
dc.contributor.scopusid7005488796
dc.date.accessioned2023-02-22T12:01:27Z
dc.date.available2023-02-22T12:01:27Z
dc.date.issued2020-02-03
dc.description.abstractRecently, studies have reported that inflammatory response and elevated platelet counts are associated with several cancers. In the present study, we aimed to evaluate hemocytometer parameters in differentiating adrenal adenoma and carcinoma, and the prognostic utility of hemocytometer parameters in adrenocortical carcinoma (ACC). We included 30 patients with nonfunctional adrenal adenoma and 13 patients with ACC having undergone surgery between 2005 and 2017 and followed up postoperatively at our centre. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), mean platelet volume (MPV) and plateletcrit (PCT) were evaluated preoperatively in all patients included in the study. There was a significant difference between the adrenal adenoma and ACC groups in terms of neutrophil and lymphocyte counts, NLR and PLR. There was no significant difference between the two groups in terms of platelet count and MPV, but PCT levels were significantly lower in ACC group. There was no statistically significant difference between recurrent and/or metastasis positive patients and negative ones according to NLR, PLR, RDW and MPV. There was a statistically significant difference in RDW levels and tumor diameter between the groups. Our study is the first to evaluate hemocytometer parameters in differentiating adrenal adenomas and carcinomas, and also in the prognosis of ACC. The present study suggested that the hemocytometer parameters may be a marker in the differential diagnosis of adrenal adenomas and carcinomas. However, our study also showed that these parameters had no prognostic value in ACC.
dc.identifier.citationŞişman, P. vd. (2020). "May hemocytometer parameters be a biomarker in distinguishing between adrenal adenomas and carcinomas and in prognosis of adrenocortical carcinomas?". Acta Clinica Croatica, 59(3), 439-444.
dc.identifier.endpage444
dc.identifier.issn0353-9466
dc.identifier.issnhttps://hrcak.srce.hr/clanak/360128
dc.identifier.issue3
dc.identifier.pubmed34177053
dc.identifier.scopus2-s2.0-85100416292
dc.identifier.startpage439
dc.identifier.urihttps://doi.org/10.20471/acc.2020.59.03.07
dc.identifier.urihttp://hdl.handle.net/11452/31125
dc.identifier.volume59
dc.identifier.wos000603080400007
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSestre Milosrdnice University Hospital
dc.relation.collaborationSanayi
dc.relation.journalActa Clinica Croatica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenal adenoma
dc.subjectAdrenocortical carcinoma
dc.subjectHemocytometer parameters
dc.subjectMean platelet volume
dc.subjectNeutrophil to lymphocyte ratio
dc.subjectNeutrophil-to-lymphocyte
dc.subjectManagement
dc.subjectCancer
dc.subjectGeneral & internal medicine
dc.subject.emtreeBiological marker
dc.subject.emtreeAdrenal cortex adenoma
dc.subject.emtreeAdrenal cortex carcinoma
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeBiochemical composition
dc.subject.emtreeCancer patient
dc.subject.emtreeCancer prognosis
dc.subject.emtreeCancer recurrence
dc.subject.emtreeCancer size
dc.subject.emtreeCancer surgery
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeData analysis software
dc.subject.emtreeDisease marker
dc.subject.emtreeDistant metastasis
dc.subject.emtreeFemale
dc.subject.emtreeFollow up
dc.subject.emtreeHematological parameters
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeLymphocyte count
dc.subject.emtreeMale
dc.subject.emtreeMean platelet volume
dc.subject.emtreeNeutrophil count
dc.subject.emtreeNeutrophil lymphocyte ratio
dc.subject.emtreePlatelet count
dc.subject.emtreePlatelet distribution width
dc.subject.emtreePlatelet lymphocyte ratio
dc.subject.emtreePlateletcrit
dc.subject.emtreePostoperative period
dc.subject.emtreePreoperative evaluation
dc.subject.emtreeRed blood cell distribution width
dc.subject.emtreeAdenoma
dc.subject.emtreeAdrenal cortex carcinoma
dc.subject.emtreeAdrenal cortex tumor
dc.subject.emtreeLymphocyte
dc.subject.emtreeNeutrophil
dc.subject.emtreePrognosis
dc.subject.meshAdenoma
dc.subject.meshAdrenal cortex neoplasms
dc.subject.meshAdrenocortical carcinoma
dc.subject.meshBiomarkers
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshNeutrophils
dc.subject.meshPlatelet count
dc.subject.meshPrognosis
dc.subject.scopusInflammation; Glasgow; Lymphocytes
dc.subject.wosMedicine, general & internal
dc.titleMay hemocytometer parameters be a biomarker in distinguishing between adrenal adenomas and carcinomas and in prognosis of adrenocortical carcinomas?
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/İç Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Endokrinoloji ve Metabolizma Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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