Publication:
The antinociceptive effects of centrally administered CDP-choline on acute

dc.contributor.buuauthorHamurtekin, Emre
dc.contributor.buuauthorGürün, M. Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
dc.contributor.researcheridAAG-8716-2019
dc.contributor.scopusid8717648500
dc.contributor.scopusid6602547850
dc.date.accessioned2021-09-13T07:24:24Z
dc.date.available2021-09-13T07:24:24Z
dc.date.issued2006-10-30
dc.description.abstractThis study investigates the antinociceptive effect of intracerebroventricular (i.c.v.) injection of cytidine-5'-diphosphate choline (CDP-choline; citicoline) and the involvement of cholinergic mechanisms in rats. Three different pain models were utilized: thermal paw withdrawal test, mechanical paw pressure test and acetic acid writhing test. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 mu mol) produced dose and time-dependent antinociception. Equimolar dose of choline (1 mu mol; i.c.v.) produced antinociceptive response similar to the one observed in CDP-choline given animals. On the other hand, cytidine (1 mu mol; i.c.v.) failed to produce response in the thermal paw withdrawal test and the mechanical paw pressure test but in the writhing test in which it produced significant antinociceptive effect. CDP-choline-induced antinociception was prevented by the neuronal high affinity choline uptake inhibitor HC-3 (1 mu g; i.c.v.), the nonselective nicotinic receptor antagonist mecamylamine (50 mu g; i.c.v.) and by the alpha(7)-selective nicotinic receptor antagonist, MLA (25 mu g; i.c.v.). However, it was not changed by the nonselective muscarinic receptor antagonist atropine (10 mu g; i.c.v.) in the thermal paw withdrawal test and mechanical paw pressure test. In the writhing test, all antagonist pretreatments produced blockade similar to that obtained from CDP-choline injected animals. CDP-choline did not impair the motor performance of rats as evaluated by a rota-rod test. Therefore, it can be postulated that CDP-choline exerts an antinociceptive effect mediated by a central cholinergic mechanism. Activation of specific alpha(7)-nicotinic cholinergic receptors through the activation of presynaptic cholinergic mechanisms appears to be involved in the antinociceptive effect of this drug.
dc.identifier.citationHamurtekin, E. ve Gurun, M. S. (2006). ''The antinociceptive effects of centrally administered CDP-choline on acute''. Brain Research, 1117(1), 92-100.
dc.identifier.endpage100
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.issue1
dc.identifier.pubmed16942753
dc.identifier.scopus2-s2.0-33750002031
dc.identifier.startpage92
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2006.07.118
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006899306023481
dc.identifier.urihttp://hdl.handle.net/11452/21876
dc.identifier.volume1117
dc.identifier.wos000242147200010
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.journalBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectCholinergicα7-nicotinic receptor
dc.subjectAntinociception
dc.subjectCytidine
dc.subjectCholine
dc.subjectCDP-choline
dc.subjectMice
dc.subjectAnalgesics
dc.subjectPain
dc.subjectNicotinic acetylcholine-receptors
dc.subjectRelease
dc.subjectCiticoline
dc.subjectActivation
dc.subjectBrain
dc.subjectSpinal-cord
dc.subjectRat hippocampal-neurons
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholine
dc.subject.wosNeurosciences
dc.titleThe antinociceptive effects of centrally administered CDP-choline on acute
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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