Publication: The antinociceptive effects of centrally administered CDP-choline on acute
dc.contributor.buuauthor | Hamurtekin, Emre | |
dc.contributor.buuauthor | Gürün, M. Sibel | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı | |
dc.contributor.researcherid | AAG-8716-2019 | |
dc.contributor.scopusid | 8717648500 | |
dc.contributor.scopusid | 6602547850 | |
dc.date.accessioned | 2021-09-13T07:24:24Z | |
dc.date.available | 2021-09-13T07:24:24Z | |
dc.date.issued | 2006-10-30 | |
dc.description.abstract | This study investigates the antinociceptive effect of intracerebroventricular (i.c.v.) injection of cytidine-5'-diphosphate choline (CDP-choline; citicoline) and the involvement of cholinergic mechanisms in rats. Three different pain models were utilized: thermal paw withdrawal test, mechanical paw pressure test and acetic acid writhing test. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 mu mol) produced dose and time-dependent antinociception. Equimolar dose of choline (1 mu mol; i.c.v.) produced antinociceptive response similar to the one observed in CDP-choline given animals. On the other hand, cytidine (1 mu mol; i.c.v.) failed to produce response in the thermal paw withdrawal test and the mechanical paw pressure test but in the writhing test in which it produced significant antinociceptive effect. CDP-choline-induced antinociception was prevented by the neuronal high affinity choline uptake inhibitor HC-3 (1 mu g; i.c.v.), the nonselective nicotinic receptor antagonist mecamylamine (50 mu g; i.c.v.) and by the alpha(7)-selective nicotinic receptor antagonist, MLA (25 mu g; i.c.v.). However, it was not changed by the nonselective muscarinic receptor antagonist atropine (10 mu g; i.c.v.) in the thermal paw withdrawal test and mechanical paw pressure test. In the writhing test, all antagonist pretreatments produced blockade similar to that obtained from CDP-choline injected animals. CDP-choline did not impair the motor performance of rats as evaluated by a rota-rod test. Therefore, it can be postulated that CDP-choline exerts an antinociceptive effect mediated by a central cholinergic mechanism. Activation of specific alpha(7)-nicotinic cholinergic receptors through the activation of presynaptic cholinergic mechanisms appears to be involved in the antinociceptive effect of this drug. | |
dc.identifier.citation | Hamurtekin, E. ve Gurun, M. S. (2006). ''The antinociceptive effects of centrally administered CDP-choline on acute''. Brain Research, 1117(1), 92-100. | |
dc.identifier.endpage | 100 | |
dc.identifier.issn | 0006-8993 | |
dc.identifier.issn | 1872-6240 | |
dc.identifier.issue | 1 | |
dc.identifier.pubmed | 16942753 | |
dc.identifier.scopus | 2-s2.0-33750002031 | |
dc.identifier.startpage | 92 | |
dc.identifier.uri | https://doi.org/10.1016/j.brainres.2006.07.118 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0006899306023481 | |
dc.identifier.uri | http://hdl.handle.net/11452/21876 | |
dc.identifier.volume | 1117 | |
dc.identifier.wos | 000242147200010 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.journal | Brain Research | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Neurosciences & neurology | |
dc.subject | Cholinergicα7-nicotinic receptor | |
dc.subject | Antinociception | |
dc.subject | Cytidine | |
dc.subject | Choline | |
dc.subject | CDP-choline | |
dc.subject | Mice | |
dc.subject | Analgesics | |
dc.subject | Pain | |
dc.subject | Nicotinic acetylcholine-receptors | |
dc.subject | Release | |
dc.subject | Citicoline | |
dc.subject | Activation | |
dc.subject | Brain | |
dc.subject | Spinal-cord | |
dc.subject | Rat hippocampal-neurons | |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | |
dc.subject.wos | Neurosciences | |
dc.title | The antinociceptive effects of centrally administered CDP-choline on acute | |
dc.type | Article | |
dc.wos.quartile | Q3 | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı | |
local.indexed.at | PubMed | |
local.indexed.at | WOS |
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