Publication:
Postischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flaps

dc.contributor.buuauthorAkın, Selçuk
dc.contributor.buuauthorÖzcan, Mesut
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPlastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0003-1683-0722
dc.contributor.researcheridAAH-5064-2021
dc.contributor.scopusid7005263372
dc.contributor.scopusid7102067678
dc.date.accessioned2021-12-07T06:50:53Z
dc.date.available2021-12-07T06:50:53Z
dc.date.issued1998
dc.description.abstractThis study investigated the possible effect of hydroxyethyl starch (HAES) as a postischemic perfusion washout on survival of skin flaps. Forty-eight, male, Sprague-Dawley rats were used in this experiment. A 4x6 cm unilateral island skin flap based on the superficial inferior epigastric artery and vein was raised. The femoral neurovascular bundle supplying the flap pedicle was also dissected free. The flaps were divided into four groups, each consisting of 12 rats. Group 1 (Nonishemic control); Group 2 (Control) - no perfusion washout; Group 3 (Saline) - postischemic washout with normal saline solution; Group 4 (HAES) - postischemic washout with hydroxyethyl starch 10% (HAES) solution. The flaps were subjected to 11 hours of warm ischemia. Thirty minutes prior to the completion of the ischemic period, the flaps were perfused with normal saline solution in group 3 and with HAES in group 4. The percentage of flap survival was assessed on postoperative day 7. Statistical analysis was performed using the Student's t-test. Flap survival rates for Group 4 (HAES) were significantly greater than Group 2 (Control nonperfusion washout) and Group 3 (saline solution) (p<0.001). This is the first study to investigate the effect of HAES on skin flap survival based on the results, HAES solution may be useful in clinical practice.
dc.identifier.citationAkın, S. ve Özcan, M. (1998). "Postischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flaps". European Journal of Plastic Surgery, 21(5), 238-242.
dc.identifier.endpage242
dc.identifier.issn0930-343X
dc.identifier.issue5
dc.identifier.scopus2-s2.0-0031822050
dc.identifier.startpage238
dc.identifier.urihttps://doi.org/10.1007/s002380050081
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs002380050081
dc.identifier.urihttp://hdl.handle.net/11452/23023
dc.identifier.volume21
dc.identifier.wos000074674100008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer-Verlag
dc.relation.journalEuropean Journal of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSurgery
dc.subjectHAES solution
dc.subjectPostischemic washout
dc.subjectSkin flap survival
dc.subjectNo-reflow phenomenon
dc.subjectSuperoxide-dismutase
dc.subjectImproved survival
dc.subjectTissue-injury
dc.subjectFree-radicals
dc.subjectPerfusion
dc.subjectInfusion
dc.subjectUrokinase
dc.subjectIloprost
dc.subjectIschemia
dc.subjectSalvage
dc.subject.emtreeHetastarch
dc.subject.emtreeSodium chloride
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeInferior epigastric artery
dc.subject.emtreeIschemia
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreePedicled skin flap
dc.subject.emtreePerfusion
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSkin flap
dc.subject.emtreeSkin flap survival
dc.subject.emtreeStatistical analysis
dc.subject.emtreeSurvival rate
dc.subject.emtreeTissue perfusion
dc.subject.scopusFree Tissue Graft; Breast Reconstruction; Flaps (Control Surfaces)
dc.subject.wosSurgery
dc.titlePostischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flaps
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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