Publication: Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus
dc.contributor.buuauthor | Güleç, Süyen Güldal | |
dc.contributor.buuauthor | Noyan, Behzat | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Fizyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0003-0863-1547 | |
dc.contributor.researcherid | C-5730-2015 | |
dc.contributor.scopusid | 6506333172 | |
dc.contributor.scopusid | 6602752303 | |
dc.date.accessioned | 2021-09-07T07:56:21Z | |
dc.date.available | 2021-09-07T07:56:21Z | |
dc.date.issued | 2000 | |
dc.description.abstract | The effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats. Rats were implanted with chronic, stainless steel screw electrodes epidurally for electrocortical recordings. A control group received 3 mEq/kg LiCl (i.p.) and 24 h later 45 mg/kg pilocarpine HCl (i.p.). Two different experimental procedures were followed: (1) L-arginine was applied in doses of 100 mg/kg, 300 mg/kg or 500 mg/kg (i.p.), 30 min before pilocarpine injection; (2) 100 mg/kg, 500 mg/kg or 1000 mg/kg (i.p.) L-arginine was injected either 5 min or 30 min after the onset of status epilepticus (SE). L-arginine (300 mg/kg) injected 30 min before pilocarpine significantly reduced the percentage of SE, but did not change the latency to SE or 24-hour survival. These parameters were not significantly affected by the 100 mg/kg or 500 mg/kg dose of L-arginine. On the other hand, no dose of L-arginine that was applied after SE had begun, had any significant influence on the seizures. We concluded that L-arginine may prevent seizure activity in some but not all doses, and does not have any effect on the ongoing seizure activity. | |
dc.identifier.citation | Noyan, B. ve Güleç, S. G. (2000). "Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus". Physiological Research, 49(3), 379-385. | |
dc.identifier.endpage | 385 | |
dc.identifier.issn | 0862-8408 | |
dc.identifier.issue | 3 | |
dc.identifier.pubmed | 11043926 | |
dc.identifier.scopus | 2-s2.0-0033840174 | |
dc.identifier.startpage | 379 | |
dc.identifier.uri | https://europepmc.org/article/med/11043926 | |
dc.identifier.uri | http://hdl.handle.net/11452/21721 | |
dc.identifier.volume | 49 | |
dc.identifier.wos | 000088843100012 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Acad Sciences Czech Republic Institute of Physiology | |
dc.relation.journal | Physiological Research | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Physiology | |
dc.subject | Nitric oxide | |
dc.subject | L-arginine | |
dc.subject | Status epilepticus | |
dc.subject | Rat | |
dc.subject | Nitric-oxide synthesis | |
dc.subject | Human temporal-lobe | |
dc.subject | Induced seizures | |
dc.subject | Brain-damage | |
dc.subject | Rats | |
dc.subject | Epilepsy | |
dc.subject | Model | |
dc.subject | Mechanisms | |
dc.subject | Acid | |
dc.subject | Mice | |
dc.subject.scopus | Arginine Vasopressin; Learning and Memory; Spatial Learning | |
dc.subject.wos | Physiology | |
dc.title | Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus | |
dc.type | Article | |
dc.wos.quartile | Q3 | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Fizyoloji Ana Bilim Dalı | |
local.indexed.at | Scopus | |
local.indexed.at | WOS |
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