Publication:
Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus

dc.contributor.buuauthorGüleç, Süyen Güldal
dc.contributor.buuauthorNoyan, Behzat
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-0863-1547
dc.contributor.researcheridC-5730-2015
dc.contributor.scopusid6506333172
dc.contributor.scopusid6602752303
dc.date.accessioned2021-09-07T07:56:21Z
dc.date.available2021-09-07T07:56:21Z
dc.date.issued2000
dc.description.abstractThe effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats. Rats were implanted with chronic, stainless steel screw electrodes epidurally for electrocortical recordings. A control group received 3 mEq/kg LiCl (i.p.) and 24 h later 45 mg/kg pilocarpine HCl (i.p.). Two different experimental procedures were followed: (1) L-arginine was applied in doses of 100 mg/kg, 300 mg/kg or 500 mg/kg (i.p.), 30 min before pilocarpine injection; (2) 100 mg/kg, 500 mg/kg or 1000 mg/kg (i.p.) L-arginine was injected either 5 min or 30 min after the onset of status epilepticus (SE). L-arginine (300 mg/kg) injected 30 min before pilocarpine significantly reduced the percentage of SE, but did not change the latency to SE or 24-hour survival. These parameters were not significantly affected by the 100 mg/kg or 500 mg/kg dose of L-arginine. On the other hand, no dose of L-arginine that was applied after SE had begun, had any significant influence on the seizures. We concluded that L-arginine may prevent seizure activity in some but not all doses, and does not have any effect on the ongoing seizure activity.
dc.identifier.citationNoyan, B. ve Güleç, S. G. (2000). "Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus". Physiological Research, 49(3), 379-385.
dc.identifier.endpage385
dc.identifier.issn0862-8408
dc.identifier.issue3
dc.identifier.pubmed11043926
dc.identifier.scopus2-s2.0-0033840174
dc.identifier.startpage379
dc.identifier.urihttps://europepmc.org/article/med/11043926
dc.identifier.urihttp://hdl.handle.net/11452/21721
dc.identifier.volume49
dc.identifier.wos000088843100012
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAcad Sciences Czech Republic Institute of Physiology
dc.relation.journalPhysiological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhysiology
dc.subjectNitric oxide
dc.subjectL-arginine
dc.subjectStatus epilepticus
dc.subjectRat
dc.subjectNitric-oxide synthesis
dc.subjectHuman temporal-lobe
dc.subjectInduced seizures
dc.subjectBrain-damage
dc.subjectRats
dc.subjectEpilepsy
dc.subjectModel
dc.subjectMechanisms
dc.subjectAcid
dc.subjectMice
dc.subject.scopusArginine Vasopressin; Learning and Memory; Spatial Learning
dc.subject.wosPhysiology
dc.titleEffects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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