Publication:
New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs

Simple item page
dc.contributor.authorFlood, Pamela
dc.contributor.authorPapke, Roger L.
dc.contributor.authorDamaj, M. Imad
dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentDeney Hayvanları Yetiştirme ve Araştırma Merkezi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridAAG-8716-2019
dc.contributor.researcheridEOB-5882-2022
dc.contributor.scopusid15062425700
dc.contributor.scopusid55664349700
dc.date.accessioned2024-03-28T10:54:20Z
dc.date.available2024-03-28T10:54:20Z
dc.date.issued2017-08-16
dc.description.abstractBackground: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this review is to introduce readers particularly to alpha 7 nAChRs in a perspective of pain and its modulation. Methods: Developments for alpha 7 nAChR modulators and recent animal studies related to pain are reviewed. Results: Accumulating evidences suggest that selective ligands for alpha 7 nAChRs hold promise in the treatment of chronic pain conditions as they lack many of side effects associated with other nicotinic receptor types. Conclusion: This review provides the reader recent insights on alpha 7 nAChRs from structure and function to the latest findings on the pharmacology and therapeutic targeting of these receptors for the treatment of pain and inflammation.
dc.description.sponsorshipUnited States Department of Health & Human Services - National Institutes of Health (NIH) - R01-CA206028 / R01GM057481
dc.identifier.citationBağdaş, D. vd. (2018). ''New insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs''. Current Neuropharmacology, 16(4), 415-425.
dc.identifier.doihttps://doi.org/10.2174/1570159X15666170818102108
dc.identifier.eissn1875-6190
dc.identifier.endpage425
dc.identifier.issn1570-159X
dc.identifier.issue4
dc.identifier.pubmed28820052
dc.identifier.scopus2-s2.0-85048949626
dc.identifier.startpage415
dc.identifier.urihttps://www.eurekaselect.com/article/85349
dc.identifier.urihttps://hdl.handle.net/11452/40650
dc.identifier.volume16
dc.identifier.wos000431914200007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.bap(KUAP (T) 2016/15)
dc.relation.collaborationYurt dışı
dc.relation.journalCurrent Neuropharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha 7 nicotinic acetylcholine receptors
dc.subjectNicotine
dc.subjectPain
dc.subjectInflammation
dc.subjectModulators
dc.subjectAnti-inflammatory
dc.subjectAgonists
dc.subjectPositive allosteric modulator
dc.subjectCholinergic antiinflammatory pathway
dc.subjectGated ion-channel
dc.subjectX-ray-structure
dc.subjectNeuropathic pain
dc.subjectAnimal-models
dc.subjectSpinal-cord
dc.subjectBinding-sites
dc.subjectHuman monocytes
dc.subjectDrug discovery
dc.subjectNeurosciences & neurology
dc.subjectPharmacology & pharmacy
dc.subject.emtreeBungarotoxin receptor
dc.subject.emtreeGelatinase B
dc.subject.emtreeGlial fibrillary acidic protein
dc.subject.emtreeHigh mobility group B1 protein
dc.subject.emtreeL kappa B
dc.subject.emtreeImmunoglobulin enhancer binding protein
dc.subject.emtreeInterleukin 1
dc.subject.emtreeInterleukin 10
dc.subject.emtreeInterleukin 18
dc.subject.emtreeInterleukin 1beta
dc.subject.emtreeInterleukin 6
dc.subject.emtreeJanus kinase 2
dc.subject.emtreeLigand gated ion channel
dc.subject.emtreeMecamylamine
dc.subject.emtreeMitogen activated protein kinase 1
dc.subject.emtreeMitogen activated protein kinase 3
dc.subject.emtreeMyeloid differentiation factor 88
dc.subject.emtreeNicotinic receptor
dc.subject.emtreePhosphatidylcholine
dc.subject.emtreeSerotonin
dc.subject.emtreeSTAT3 protein
dc.subject.emtreeSuppressor of cytokine signaling 3
dc.subject.emtreeToll like receptor 4
dc.subject.emtreeTumor necrosis factor
dc.subject.emtreeAnalgesic agent
dc.subject.emtreeCholinergic receptor stimulating agent
dc.subject.emtreeNicotinic receptor
dc.subject.emtreeNonsteroid antiinflammatory agent
dc.subject.emtreeAntiinflammatory activity
dc.subject.emtreeBinding site
dc.subject.emtreeChronic pain
dc.subject.emtreeConformational transition
dc.subject.emtreeCytokine production
dc.subject.emtreeCytokine release
dc.subject.emtreeDesensitization
dc.subject.emtreeDown regulation
dc.subject.emtreeHuman
dc.subject.emtreeInflammation
dc.subject.emtreeMacrophage migration
dc.subject.emtreeNeuropathic pain
dc.subject.emtreeNonhuman
dc.subject.emtreePain
dc.subject.emtreePhosphorylation
dc.subject.emtreeProtein expression
dc.subject.emtreeReview
dc.subject.emtreeSignal transduction
dc.subject.emtreeUpregulation
dc.subject.emtreeAnimal
dc.subject.emtreeDrug effect
dc.subject.emtreeInflammation
dc.subject.emtreeMetabolism
dc.subject.emtreeNerve cell
dc.subject.emtreePain
dc.subject.meshAnalgesics
dc.subject.meshAnimals
dc.subject.meshAnti-inflammatory agents
dc.subject.meshNon-steroidal
dc.subject.meshCholinergic agents
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshNeurons
dc.subject.meshPain
dc.subject.meshReceptors, nicotinic
dc.subject.scopusInflammation; Methyllycaconitine; 3-(2,4-Dimethoxybenzylidene)Anabaseine
dc.subject.wosNeurosciences
dc.subject.wosPharmacology & pharmacy
dc.titleNew insights on neuronal nicotinic acetylcholine receptors as targets for pain and inflammation: A focus on α7 nAChRs
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bağdaş_vd_2018.pdf
Size:
393.13 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

İndeksli Yayınlar / Indexed Publications