Publication:
Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia

dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.buuauthorÇetinkaya, Merih
dc.contributor.buuauthorKılıç, Serkan
dc.contributor.buuauthorÇelebi, Solmaz
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.buuauthorBudak, Ferah
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.departmentTıbbi Mikrobiyoloji Ana Bilim Dalı
dc.contributor.departmentÇocuk İmmünolojisi Bölümü
dc.contributor.departmentÇocuk Enfeksiyon Hastalıkları Bölümü
dc.contributor.departmentNeonatoloji Bölümü
dc.contributor.departmentİmmünoloji Bölümü
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.researcheridK-7285-2012
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridAAG-8393-2021
dc.date.accessioned2021-12-14T11:51:14Z
dc.date.available2021-12-14T11:51:14Z
dc.date.issued2012-03
dc.description.abstractObjective: The aim of this study was to determine the serum mannose-binding lectin (MBL) levels and the frequency of MBL gene polymorphisms in infants with neonatal sepsis. Study Design: Between January 2008 and January 2010, a total of 93 infants were included in this study and 53 of them had neonatal sepsis diagnosis as study group and 40 infants who had no sepsis according to clinical and laboratory findings as control group. Result: Serum MBL levels were found to be low in 17 of 93 infants. Eleven of them were in the sepsis group and six of them were in the control group. Serum MBL levels were significantly lower in infants with sepsis compared with the control group. Frequencies of genotype AB and BB were also significantly higher in the study group compared with the control group. Most importantly, presence of B allele of MBL exon 1 gene was found to be associated with an increased risk for neonatal sepsis. Additionally, in the study group, the mean serum MBL levels were found to be significantly lower in the premature infants compared with the term infants. Pneumonia, bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) were significantly higher in infants with MBL deficiency compared with infants with normal MBL levels. Conclusion: Low MBL levels and presence of B allele of MBL exon 1 gene were found to be important risk factors for development of both neonatal sepsis and pneumonia, especially in premature infants. Low MBL levels and MBL gene polymorphisms might also be associated with inflammation-related neonatal morbidities such as BPD and IVH.
dc.identifier.citationÖzkan, H. vd. (2012). "Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia". Journal of Perinatology, 32(3), 210-217.
dc.identifier.endpage217
dc.identifier.issn0743-8346
dc.identifier.issn1476-5543
dc.identifier.issue3
dc.identifier.pubmed21681178
dc.identifier.scopus2-s2.0-84857923927
dc.identifier.startpage210
dc.identifier.urihttps://doi.org/10.1038/jp.2011.79
dc.identifier.urihttps://www.nature.com/articles/jp201179
dc.identifier.urihttp://hdl.handle.net/11452/23264
dc.identifier.volume32
dc.identifier.wos000300875000008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringernature
dc.relation.bapT-2006/52
dc.relation.journalJournal of Perinatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObstetrics & gynecology
dc.subjectPediatrics
dc.subjectNeonatal sepsis
dc.subjectMannan-binding lectin
dc.subjectPremature infant
dc.subjectGene polymorphism
dc.subjectPreterm infants
dc.subjectInfection
dc.subjectRisk
dc.subjectSusceptibility
dc.subjectComplement
dc.subjectProtein
dc.subjectInvolvement
dc.subjectDeficiency
dc.subjectMutations
dc.subjectVariants
dc.subject.emtreeMannose binding lectin
dc.subject.emtreeAllele
dc.subject.emtreeArticle
dc.subject.emtreeBrain hemorrhage
dc.subject.emtreeControlled study
dc.subject.emtreeDna polymorphism
dc.subject.emtreeFemale
dc.subject.emtreeGene frequency
dc.subject.emtreeGenetic association
dc.subject.emtreeGenetic risk
dc.subject.emtreeGenotype
dc.subject.emtreeHuman
dc.subject.emtreeLung dysplasia
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeMannose binding lectin gene
dc.subject.emtreeMutator gene
dc.subject.emtreeNewborn
dc.subject.emtreeNewborn morbidity
dc.subject.emtreeNewborn sepsis
dc.subject.emtreePneumonia
dc.subject.emtreePrematurity
dc.subject.emtreeProtein blood level
dc.subject.meshCase-control studies
dc.subject.meshFemale
dc.subject.meshGenetic predisposition to disease
dc.subject.meshGenotyping techniques
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, newborn
dc.subject.meshInfant, premature
dc.subject.meshInfant, premature, diseases
dc.subject.meshIntensive care, neonatal
dc.subject.meshMale
dc.subject.meshMannose-binding lectin
dc.subject.meshPneumonia
dc.subject.meshPolymorphism, genetic
dc.subject.meshRisk factors
dc.subject.meshSepsis
dc.subject.scopusMannose-Binding Lectins; Ficolin; Collectins
dc.subject.wosObstetrics & gynecology
dc.subject.wosPediatrics
dc.titleSerum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia
dc.typeArticle
dc.wos.quartileQ2 (Obstetrics & gynecology)
dc.wos.quartileQ1 (Pediatrics)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı/Neonatoloji Bölümü
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı/Çocuk İmmünolojisi Bölümü
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı/Çocuk Enfeksiyon Hastalıkları Bölümü
local.contributor.departmentTıp Fakültesi/Tıbbi Mikrobiyoloji Ana Bilim Dalı/İmmünoloji Bölümü
local.indexed.atPubMed
local.indexed.atWOS

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