Publication: Treatment efficacy of ribociclib or palbociclib plus letrozole in hormone receptor-positive/HER2-negative metastatic breast cancer
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Date
2023-05-03
Authors
Kahraman, Seda
Erul, Enes
Seyyar, Mustafa
Gumusay, Ozge
Bayram, Ertugrul
Demirel, Burcin Cakan
Acar, Omer
Aksoy, Sercan
Baytemur, Naziyet Kose
Sahin, Elif
Journal Title
Journal ISSN
Volume Title
Publisher
Future Medicine Ltd
Abstract
Background: Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase inhibitors as the first-line standard-of-care for patients with hormone receptor-positive, HER2-negative metastatic breast cancer. Methods: The authors report retrospective real-life data for 600 patients with estrogen receptor- and/or progesterone receptor-positive and HER2-negative metastatic breast cancer who were treated with ribociclib and palbociclib in combination with letrozole. Results & conclusion: The results demonstrated that the combination of palbociclib or ribociclib with letrozole has similar progression-free survival and overall survival benefit in real life for the patient group with similar clinical features. Specifically, endocrine sensitivity may be a factor to be considered in the treatment preference.
Description
Keywords
Cdk 4, 6 inhibitors, Her2-negative metastatic breast cancer, Hr-positive, Letrozole, Oncology