Publication:
Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia

dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorŞafak, Özlem
dc.contributor.buuauthorMelahat, Dirican
dc.contributor.buuauthorUncu, Gürkan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyokimya Ana Bilim Dalı
dc.contributor.departmentKadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.contributor.orcid0000-0002-2593-7196
dc.contributor.researcheridABE-1716-2020
dc.contributor.researcheridAAG-6985-2021
dc.contributor.scopusid55943324800
dc.contributor.scopusid6508363078
dc.contributor.scopusid6601919847
dc.contributor.scopusid6603716169
dc.date.accessioned2021-10-07T12:35:03Z
dc.date.available2021-10-07T12:35:03Z
dc.date.issued2004-11
dc.description.abstractLipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy were included in this study. Serum malondialdehyde (MDA) level, an indicator of lipid peroxidation, was measured by high-performance liquid chromatography (HPLC). The oxidizability of apolipoprotein B-containing lipoproteins was evaluated by copper-induced in vitro peroxidation of the isolated fraction of apolipoprotein B-containing lipoproteins coupled with the thiobarbituric acid-reactive substances assay and expressed as the difference between copper-treated MDA and basal MDA (ΔMDA). The serum paraoxonase and arylesterase activities were determined spectrophotometrically. Serum MDA and ΔMDA levels of apolipoprotein B-containing lipoproteins were significantly higher in both mild and severe preeclampsia groups than in the normal pregnant group. Serum paraoxonase and arylesterase activities were not significantly different among the study groups. Enhancement in oxidizability of apolipoprotein B-containing lipoproteins accompanying with dyslipidemia and increased serum MDA levels suggests that those lipoproteins play a role in the pathogenesis of preeclampsia. Further studies are needed to investigate serum paraoxonase activity in women with normal pregnancies and preeclampsia.
dc.identifier.citationSarandöl, E. vd. (2004). “Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia”. Clinical Biochemistry, 37(11), 990-996.
dc.identifier.endpage996
dc.identifier.issn0009-9120
dc.identifier.issue11
dc.identifier.pubmed15498527
dc.identifier.scopus2-s2.0-6344220183
dc.identifier.startpage990
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2004.06.013
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912004001791
dc.identifier.urihttp://hdl.handle.net/11452/22286
dc.identifier.volume37
dc.identifier.wos000225389900008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.journalClinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArylesterase
dc.subjectLipoprotein oxidation
dc.subjectMalondialdehyde
dc.subjectParaoxonase
dc.subjectPreeclampsia
dc.subjectLow-density-lipoprotein
dc.subjectPregnancy-induced hypertension
dc.subjectEndothelial dysfunction
dc.subjectOxidative modification
dc.subjectParaoxonase arylesterase
dc.subjectLipid-peroxidation
dc.subjectHDL-cholesterol
dc.subjectVitamin-E
dc.subjectPlasma
dc.subjectWomen
dc.subjectMedical laboratory technology
dc.subject.emtreeApolipoprotein B
dc.subject.emtreeAryldialkylphosphatase
dc.subject.emtreeArylesterase
dc.subject.emtreeCopper
dc.subject.emtreeLipid
dc.subject.emtreeLipoprotein
dc.subject.emtreeMalonaldehyde
dc.subject.emtreeThiobarbituric acid reactive substance
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeAssay
dc.subject.emtreeBlood level
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeDisease severity
dc.subject.emtreeEnzyme activity
dc.subject.emtreeEvaluation
dc.subject.emtreeFemale
dc.subject.emtreeHigh performance liquid chromatography
dc.subject.emtreeHuman
dc.subject.emtreeIn vitro study
dc.subject.emtreeIsolation procedure
dc.subject.emtreeLipid peroxidation
dc.subject.emtreeMeasurement
dc.subject.emtreeOxidation
dc.subject.emtreePeroxidation
dc.subject.emtreePreeclampsia
dc.subject.emtreePregnancy
dc.subject.emtreePriority journal
dc.subject.emtreeProtein expression
dc.subject.emtreeSerum
dc.subject.emtreeSpectrophotometry
dc.subject.meshApolipoproteins B
dc.subject.meshAryldialkylphosphatase
dc.subject.meshCarboxylic ester hydrolases
dc.subject.meshCopper
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLipid peroxidation
dc.subject.meshLipoproteins
dc.subject.meshMalondialdehyde
dc.subject.meshOxidation-reduction
dc.subject.meshPre-eclampsia
dc.subject.meshPregnancy
dc.subject.scopusPregnancy Toxemia; Maternal Hypertension; Eclampsia
dc.subject.wosMedical laboratory technology
dc.titleOxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Kadın Hastalıkları ve Doğum Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: