Publication:
Expression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survival

dc.contributor.authorÇelik, Nilüfer
dc.contributor.authorBilgin, Tevfik
dc.contributor.buuauthorÖzuysal, Sema
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorÖzgür, Tümay
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Onkoloji Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-9732-5340
dc.contributor.researcheridAAJ-1027-2021
dc.contributor.researcheridAAA-1530-2020
dc.contributor.scopusid56616314600
dc.contributor.scopusid54584171000
dc.contributor.scopusid54584171000
dc.date.accessioned2021-12-23T07:53:47Z
dc.date.available2021-12-23T07:53:47Z
dc.date.issued2009
dc.description.abstractObjective: To evaluate the expression of cyclooxygenase (COX)-2 in ovarian serous carcinomas (OSC) and its correlation with microvessel density (MVD), nm23 expression, clinicopathologic prognostic factors and survival. Methods: Specimens from 44 patients with OSC were evaluated by immunohistochemistry for COX-2 and nm23 expression. Tumor MVD was assessed with CD34 immunostaining. The survival data of the patients were found from data files. Results: 40 specimens (90.1%) showed positive COX-2 staining. Patients with high COX-2-expressed tumors had shorter overall survival, but it was not statistically significant. No correlation was found between COX-2 expression and clinicopathologic variables. There was no significant correlation between COX-2 and nm23 expression or MVD. Conclusions: COX-2 is frequently expressed in OSC. Although we could not confirm the prognostic significance of Cox-2 expression in the present cohort of OSC patients, the p value for overall Survival was just slightly greater than alpha, and this result can be referred as almost significant. We considered that the limited number of cases in Our study might affect the statistical analysis of our results. Further studies involving a larger number of patients are needed to clarify the prognostic significance of COX-2 expression in ovarian carcinomas.
dc.identifier.citationÖzuysal, S. vd. (2009). "Expression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survival". European Journal of Gynaecological Oncology, 30(6), 640-645.
dc.identifier.endpage645
dc.identifier.issn0392-2936
dc.identifier.issue6
dc.identifier.pubmed20099494
dc.identifier.scopus2-s2.0-70949090063
dc.identifier.startpage640
dc.identifier.urihttp://hdl.handle.net/11452/23483
dc.identifier.volume30
dc.identifier.wos000271614400008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherImr Press
dc.relation.bapT-2006/15
dc.relation.collaborationSanayi
dc.relation.journalEuropean Journal of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiogenesis
dc.subjectCD34
dc.subjectCOX-2
dc.subjectCyclooxygenase-2
dc.subjectImmunohistochemistry
dc.subjectnm23
dc.subjectOvarian serous carcinoma
dc.subjectPrognosis
dc.subjectIntestinal epithelial-cells
dc.subjectMetastasis-related nm23-h1
dc.subjectColon-cancer cells
dc.subjectPrognostic-significance
dc.subjectTumor angiogenesis
dc.subjectBreast-carcinoma
dc.subjectMolecular markers
dc.subjectGene-expression
dc.subjectGrowth
dc.subjectAdenocarcinomas
dc.subjectOncology
dc.subjectObstetrics & gynecology
dc.subject.emtreeCyclooxygenase 2
dc.subject.emtreeNucleoside diphosphate kinase NM23
dc.subject.emtreeAdult
dc.subject.emtreeAged
dc.subject.emtreeAngiogenesis
dc.subject.emtreeArticle
dc.subject.emtreeCancer survival
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeOvary carcinoma
dc.subject.emtreePrognosis
dc.subject.emtreeProtein expression
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCyclooxygenase 2
dc.subject.meshCystadenoma, serous
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshKaplan-meiers estimate
dc.subject.meshMicrovessels
dc.subject.meshMiddle aged
dc.subject.meshNeovascularization, pathologic
dc.subject.meshNM23 nucleoside diphosphate kinases
dc.subject.meshOvarian neoplasms
dc.subject.meshSurvival analysis
dc.subject.scopusCyclooxygenase 2; Celecoxib; Prostaglandin Synthase
dc.subject.wosOncology
dc.subject.wosObstetrics & gynecology
dc.titleExpression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survival
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Onkoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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