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The immunohistochemical expression of c-met is an independent predictor of survival in patients with glioblastoma multiforme

dc.contributor.buuauthorÖlmez, O. F.
dc.contributor.buuauthorÇubukçu, E.
dc.contributor.buuauthorÇUBUKÇU, ERDEM
dc.contributor.buuauthorEvrensel, T.
dc.contributor.buuauthorEVRENSEL, TÜRKKAN
dc.contributor.buuauthorKurt, M.
dc.contributor.buuauthorAvcı, N.
dc.contributor.buuauthorTolunay, S.
dc.contributor.buuauthorTOLUNAY, ŞAHSİNE
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorDeligönül, Adem
dc.contributor.buuauthorDELİGÖNÜL, ADEM
dc.contributor.buuauthorHartavi, M.
dc.contributor.buuauthorAlkış, N.
dc.contributor.buuauthorManavoğlu, O.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/ Onkoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/NöroPatoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridAAJ-1027-2021
dc.contributor.researcheridAAA-3961-2020
dc.contributor.researcheridAAI-1612-2021
dc.date.accessioned2024-08-15T08:01:23Z
dc.date.available2024-08-15T08:01:23Z
dc.date.issued2014-02-01
dc.description.abstractBecause the outcome of glioblastoma multiforme (GBM) remains dismal, there is an urgent need for a better molecular characterization of this malignancy. The aim of this prospective study was to investigate the prognostic impact of the expression of c-mesenchymal-epithelial transition (c-Met) a receptor tyrosine kinase implicated in expression growth, survival, motility/migration, and invasion in GMB patients managed according to the established diagnostic and therapeutic protocols.Between May 2003 and March 2011, a total of 69 patients (33 males and 36 females; mean age: 52.2 +/- A 12.9 years, age range: 23-81 years) referred to our Department for the surgical removal of GBM were evaluated immunohistochemically for c-Met expression. Progression-free survival (PFS) and overall survival (OS) served as the main outcome measures.Compared with c-Met- subjects (n = 38), c-Met+ subjects (n = 31) had both a significantly lower OS (15.3 +/- A 2.3 vs. 22.6 +/- A 2.5 months, respectively, p < 0.01) and PFS (12.3 +/- A 2.1 vs. 19.1 +/- A 2.6 months, respectively, p < 0.05). After allowance for potential confounders, multivariate Cox regression analysis identified c-Met+ as an independent predictor of both OS (hazard ratio = 1.7; 95 % confidence interval = 1.2-1.9, p < 0.01) and PFS (hazard ratio = 1.6; 95 % confidence interval = 1.1-2.3, p < 0.05).Our findings suggest that c-Met immunohistochemical expression is an independent predictor of outcomes in patients with GBM treated by standard of care.
dc.identifier.doi10.1007/s12094-013-1059-4
dc.identifier.endpage177
dc.identifier.issn1699-048X
dc.identifier.issue2
dc.identifier.startpage173
dc.identifier.urihttps://doi.org/10.1007/s12094-013-1059-4
dc.identifier.urihttps://hdl.handle.net/11452/44043
dc.identifier.volume16
dc.identifier.wos000330964300009
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer International Publishing Ag
dc.relation.journalClinical & Translational Oncology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.subjectHepatocyte growth-factor
dc.subjectKinase inhibitor
dc.subjectPrognostic-significance
dc.subjectCancer
dc.subjectGliomas
dc.subjectTarget
dc.subjectTherapy
dc.subjectGlioblastoma multiforme
dc.subjectPrognosis
dc.subjectC-met
dc.subjectImmunohistochemistry
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.titleThe immunohistochemical expression of c-met is an independent predictor of survival in patients with glioblastoma multiforme
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublicationeceff514-6af7-4c3b-a146-b77546565a6c
relation.isAuthorOfPublication13dc6562-e9fe-42fa-8973-dcd80444844e
relation.isAuthorOfPublicatione929e321-8731-462f-8655-65e237321fef
relation.isAuthorOfPublicationedfc19d5-ce9e-4fbd-8a24-07492003c264
relation.isAuthorOfPublication.latestForDiscoveryf971677f-09c5-4463-bf01-3c6341fbe5f7

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