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A comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells

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dc.contributor.buuauthorÇelikler, Serap
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorBilaloǧlu, Rahmi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.orcid0000-0002-4177-3478
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.researcheridAAH-2767-2021
dc.contributor.researcheridAAH-5296-2021
dc.contributor.scopusid8234554800
dc.contributor.scopusid26533892300
dc.contributor.scopusid6505804122
dc.date.accessioned2024-04-03T06:02:05Z
dc.date.available2024-04-03T06:02:05Z
dc.date.issued2007-09
dc.description.abstractPyrimethamine is an antimalarial agent widely used in clinical therapy. We aimed to compare its mutagenic potential in mammalian spermatogonial and bone marrow cells. For studying chromosomal aberrations mice were treated acutely (single treatment) with 4 dose levels of pyrimethamine (5, 10, 20 and 40 mg/kg). Pyrimethamine was found to produce a significant increase in structural chromosomal aberrations after acute treatment in bone marrow cells of mice (p < 0.001). It also induced chromosome abnormalities in spermatogonial cells (p < 0.05) at the highest dose.
dc.identifier.citationÇelikler, S. vd. (2007). "A comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells". Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 62(9-10), 679-683.
dc.identifier.endpage683
dc.identifier.issn0939-5075
dc.identifier.issue9-10
dc.identifier.pubmed18069240
dc.identifier.scopus2-s2.0-36148968971
dc.identifier.startpage679
dc.identifier.urihttps://doi.org/10.1515/znc-2007-9-1009
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/znc-2007-9-1009/html
dc.identifier.urihttps://hdl.handle.net/11452/40925
dc.identifier.volume62
dc.identifier.wos000251331700009
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.journalZeitschrift fur Naturforschung - Section C Journal of Biosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIn-vivo mouse
dc.subjectMicronucleus test
dc.subjectSperm morphology
dc.subjectDaraprim
dc.subjectFragile sites
dc.subjectInduction
dc.subjectMutagenicity
dc.subjectTeratogenicity
dc.subjectSpermatogenesis
dc.subjectAssays
dc.subjectMammalia
dc.subjectMus
dc.subjectBiochemistry & molecular biology
dc.subjectPharmacology & pharmacy
dc.subject.scopusHyperpigmentation; Cyanocobalamin; Megaloblastic Anemia
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosPharmacology & pharmacy
dc.titleA comparative study on the genotoxic effect of pyrimethamine in bone marrow and spermatogonial mice cells
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atWOS
local.indexed.atScopus

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