Publication:
Vincristine modulates the expression of Ki67 and apoptosis in naturally occurring canine transmissible venereal tumor (TVT)

dc.contributor.authorBaştan, Ayhan
dc.contributor.authorBaştan, İdil
dc.contributor.authorDarbaz, İsfendiyar
dc.contributor.authorSalar, Seçkin
dc.contributor.authorKarakaş, Kübra
dc.contributor.buuauthorÖzalp, Gözde Rabia
dc.contributor.buuauthorZik, Berrin
dc.contributor.buuauthorPeker, Sabire
dc.contributor.buuauthorÖzdemir, Emsal Sinem Salcı
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentJinekoloji ve Doğum Ana Bilim Dalı
dc.contributor.departmentHistoloji ve Embriyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-4694-6937
dc.contributor.researcheridAAH-9810-2021
dc.contributor.researcheridAAE-3607-2019
dc.contributor.scopusid23985710500
dc.contributor.scopusid6507763192
dc.contributor.scopusid55109615900
dc.contributor.scopusid55249919300
dc.date.accessioned2022-04-12T07:59:22Z
dc.date.available2022-04-12T07:59:22Z
dc.date.issued2012-07
dc.description.abstractWe investigated eight adult dogs that were brought to veterinary clinics with a history of transmissible venereal tumors (TVT). Our goal was to demonstrate the occurrence of apoptosis and the cessation of cell proliferation at every phase of scheduled chemotherapy for naturally occurring TVT. Tissue samples were collected immediately after weekly treatments with vincristine sulfate and processed for histological purposes. Sections 5 mu m thick were stained by the TUNEL reaction for apoptosis and immunostained for Ki67 as a proliferation marker. We observed that after vincristine applications, tumor cell proliferation ceased and apoptosis increased. Ki67 HSCORE values were significantly lowered after the first and second treatments with the chemotherapeutic agent compared to controls, whereas TUNEL HSCORE values were significantly higher after two applications of vincristine compared to controls. Our results suggest that scheduled vincristine sulfate applications stabilize the induction of tumor regression by inducing apoptosis and preventing cell proliferation.
dc.identifier.citationÖzalp, G. R. vd. (2012). "Vincristine modulates the expression of Ki67 and apoptosis in naturally occurring canine transmissible venereal tumor (TVT)". Biotechnic & Histochemistry, 87(5), 325-330.
dc.identifier.endpage330
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5
dc.identifier.pubmed22404564
dc.identifier.scopus2-s2.0-84862184836
dc.identifier.startpage325
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.655311
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/10520295.2012.655311
dc.identifier.urihttp://hdl.handle.net/11452/25727
dc.identifier.volume87
dc.identifier.wos000305076900002
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.collaborationYurt içi
dc.relation.journalBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiotechnology & applied microbiology
dc.subjectCell biology
dc.subjectApoptosis
dc.subjectCanine
dc.subjectTVT
dc.subjectVincristine sulfate
dc.subjectGrowth
dc.subjectRegression
dc.subjectSarcoma
dc.subjectChemotherapy
dc.subjectProgression
dc.subjectEfficacy
dc.subjectTherapy
dc.subjectDogs
dc.subjectCell
dc.subject.emtreeKi 67 antigen
dc.subject.emtreeTubulin modulator
dc.subject.emtreeVincristine
dc.subject.emtreeAnimal
dc.subject.emtreeAnimal venereal tumor
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeDog
dc.subject.emtreeDog disease
dc.subject.emtreeDrug effect
dc.subject.emtreeFemale
dc.subject.emtreeGene expression regulation
dc.subject.emtreeMale
dc.subject.emtreeMetabolism
dc.subject.meshAnimals
dc.subject.meshApoptosis
dc.subject.meshDog diseases
dc.subject.meshDogs
dc.subject.meshFemale
dc.subject.meshGene Expression Regulation
dc.subject.meshKi-67 antigen
dc.subject.meshMale
dc.subject.meshTubulin modulators
dc.subject.meshVenereal tumors, veterinary
dc.subject.meshVincristine
dc.subject.scopusTransmissible Venereal Tumors; Sarcophilus Harrisii; Devil
dc.subject.wosBiotechnology & applied microbiology
dc.subject.wosCell biology
dc.titleVincristine modulates the expression of Ki67 and apoptosis in naturally occurring canine transmissible venereal tumor (TVT)
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Jinekoloji ve Doğum Ana Bilim Dalı
local.contributor.departmentVeteriner Fakültesi/Histoloji ve Embriyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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