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Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions

dc.contributor.buuauthorÖzgüç, Halil
dc.contributor.buuauthorTokyay, Rifat
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorSürmen Gür, Esma
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyokimya Ana Bilim Dalı
dc.contributor.departmentGenel Cerrahi Ana Bilim Dalı
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.departmentBeyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.contributor.orcid0000-0001-7377-9682
dc.contributor.orcid0000-0003-0841-8201
dc.contributor.researcheridAAG-7070-2021
dc.contributor.researcheridAAG-7327-2021
dc.contributor.scopusid6603867989
dc.contributor.scopusid7003296847
dc.contributor.scopusid6602597846
dc.contributor.scopusid57222002284
dc.contributor.scopusid7801407302
dc.contributor.scopusid7004641343
dc.date.accessioned2023-11-23T06:36:04Z
dc.date.available2023-11-23T06:36:04Z
dc.date.issued2003-04
dc.description.abstractThe sensitivity of liver to warm ischemia has always been a concern for surgeons. To monitor the ischemia and/or reperfusion injury after the Pringle maneuver (occlusion of porta hepatis) in livers subjected to hemorrhage, blood pressure, blood pH, base deficit (BE), serum alanine aminotransferase (ALT), serum and liver malondialdehyde (MDA), and liver glutathione (GSH) levels were measured. MDA is a by-product of oxidant induced lipid peroxidation, and GSH is an endogenous antioxidant. The effect of lactated Ringer's (LR) resuscitation with or without the addition of 2-oxothiazolidine-4-carboxylate (OTC), a cysteine prodrug (enhancing glutathione production) on liver injury, if any, were investigated. Rats in the sham group (n = 8) and five other groups (n = 8) underwent femoral artery and vein catheterization and laparotomy. The hemorrhage group was bled 30% of their blood volume and the ischemia group underwent occlusion of the porta hepatis 30 minutes. The hemorrhage-ischemia (HI), LR, and OTC groups underwent both hemorrhage and occlusion. The LR and OTC groups, 30 minutes after hemorrhage, received either LR resuscitation (equivalent to three times the shed blood) or LR resuscitation plus IV OTC (100 mg/kg before clamping and 100 mg/kg after declamping). Porta hepatis occlusion in the presence of hypovolemia (HI group) caused an increase in serum ALT, plasma MDA, liver NIDA, and base deficit and a decrease in blood pH levels. LR resuscitation lowered only MDA (plasma and liver) and base deficit but did not reduce ALT and increase blood pH. Although liver GSH did not change, OTC kept all parameters at control levels. OTC prevents the deleterious effects of total hepatic inflow occlusion under hypovolemic conditions, but this does not occur through enhancement liver glutathione production. OTC may protect the liver by accelerating hepatic glutathione turnover, but further studies are needed to explain its mechanism of action.
dc.identifier.citationÖzgüç, H. vd. (2003). “Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions”. World Journal of Surgery, 27(4), 448-454.
dc.identifier.endpage454
dc.identifier.issn0364-2313
dc.identifier.issue4
dc.identifier.pubmed12658491
dc.identifier.scopus2-s2.0-0042744783
dc.identifier.startpage448
dc.identifier.urihttps://doi.org/10.1007/s00268-002-6551-x
dc.identifier.urihttps://link.springer.com/article/10.1007/s00268-002-6551-x
dc.identifier.urihttp://hdl.handle.net/11452/34987
dc.identifier.volume27
dc.identifier.wos000182421900015
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.journalWorld Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSurgery
dc.subjectIschemia-reperfusion injury
dc.subjectHemorrhagic-shock
dc.subjectN-acetylcysteine
dc.subjectRat-liver
dc.subjectLipid peroxides
dc.subjectFree-radicals
dc.subjectGlutathione
dc.subjectResuscitation
dc.subjectDysfunction
dc.subjectL-2-oxothiazolidine-4-carboxylate
dc.subject.emtree2 oxo 4 thiazolidinecarboxylic acid
dc.subject.emtreeAlanine aminotransferase
dc.subject.emtreeGlutathione
dc.subject.emtreeLiver protective agent
dc.subject.emtreeMalonaldehyde
dc.subject.emtreeRinger lactate solution
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBleeding
dc.subject.emtreeBlood ph
dc.subject.emtreeBlood pressure
dc.subject.emtreeControlled study
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug mechanism
dc.subject.emtreeFemoral artery
dc.subject.emtreeHypovolemia
dc.subject.emtreeIschemia
dc.subject.emtreeLaparotomy
dc.subject.emtreeLipid peroxidation
dc.subject.emtreeLiver hilus
dc.subject.emtreeLiver injury
dc.subject.emtreeLiver protection
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeReperfusion injury
dc.subject.emtreeTreatment outcome
dc.subject.emtreeVein catheterization
dc.subject.meshAnimals
dc.subject.meshConstriction
dc.subject.meshHepatic artery
dc.subject.meshHypovolemia
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshModels, animal
dc.subject.meshPortal vein
dc.subject.meshPyrrolidonecarboxylic acid
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshReperfusion injury
dc.subject.meshThiazoles
dc.subject.meshThiazolidines
dc.subject.scopusCarboxylic Acids; Acetaminophen; Glutathione GSH
dc.subject.wosSurgery
dc.titleOxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Genel Cerrahi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Beyin ve Sinir Cerrahisi Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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