Publication:
Statistical shape analysis of subthalamic nucleus in patients with parkinson disease

dc.contributor.authorÖztürk, Sait
dc.contributor.authorGönen, Murat
dc.contributor.authorErol, Fatih Serhat
dc.contributor.authorKocabıçak, Ersoy
dc.contributor.buuauthorKaya, Mehmet Onur
dc.contributor.buuauthorErcan, İlker
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.orcid0000-0001-8052-0484
dc.contributor.researcheridV-9415-2018
dc.contributor.researcheridABF-2367-2020
dc.contributor.scopusid56689249200
dc.contributor.scopusid6603789069
dc.date.accessioned2023-10-19T11:47:07Z
dc.date.available2023-10-19T11:47:07Z
dc.date.issued2019-06
dc.description.abstractObjective: Subthalamic nucleus (STN) is the most targeted localization in the treatment of Parkinson disease (PD) with deep brain stimulation. However, no studies have been found in the literature about possible shape changes of STN in the literature. We aimed to investigate possible shape changes in the STN and the relationship between shape changes and disease duration in PD patients by using statistical analysis. Methods: Patients who were diagnosed with idiopathic PD and controls were enrolled in this study. Age, sex, and disease duration of all cases were recorded. Turbo-spin-echo T2-weighted axial series parallel to the skull base in each case containing midbrain images were obtained, including the whole STN. Standard anatomic landmarks were selected and marked on each digital image using a special software in all cases. Statistical geometric shape and deformation analysis of STN was performed in 2 groups. Results: Forty-three patients with PD and 50 age/sex-matched controls were enrolled in this study. There were statistically significant left and right STN shape differences between the groups. Maximum deformation was seen in the dorsolateral parts of both STNs. General shape variability of the STNs was found on the left (0.096) and right (0.049). Conclusions: Significant shape differences and remarkable deformation of STN are seen in patients with PD compared with controls. Maximum deformation was observed in the dorsolateral part of the STN, and with the increase in the duration of the PD, shape differences and deformations became more prominent.
dc.identifier.citationÖztürk, S. vd. (2019). "Statistical shape analysis of subthalamic nucleus in patients with parkinson disease". World Neurosurgery, 126, e835-e841.
dc.identifier.endpagee841
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pubmed30862597
dc.identifier.scopus2-s2.0-85063918862
dc.identifier.startpagee835
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1878875019306035
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2019.02.180
dc.identifier.urihttp://hdl.handle.net/11452/34464
dc.identifier.volume126
dc.identifier.wos000469222400104
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.indexed.wosSSCI
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.collaborationYurt içi
dc.relation.journalElsevier
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDeep brain stimulation
dc.subjectSubthalamic nucleus
dc.subjectParkinson disease
dc.subjectStatistical shape analysis
dc.subjectSubthalamic nucleus
dc.subjectNeuronal-activity
dc.subjectNeurosciences & neurology
dc.subjectSurgery
dc.subjectDeformation
dc.subjectAged
dc.subjectBrain mapping
dc.subjectDiagnostic imaging
dc.subjectFemale
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle aged
dc.subjectNuclear magnetic resonance imaging
dc.subjectOrgan size
dc.subject.meshAged
dc.subject.meshBrain mapping
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMagnetic resonance imaging
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshOrgan size
dc.subject.meshParkinson disease
dc.subject.meshSubthalamic nucleus
dc.subject.scopusBrain Depth Stimulation; Subthalamic Nucleus; Parkinson Disease
dc.subject.wosClinical neurology
dc.subject.wosSurgery
dc.titleStatistical shape analysis of subthalamic nucleus in patients with parkinson disease
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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