Publication:
Genetic variations of DNA repair genes in breast cancer

dc.contributor.authorÖzgöz, Asuman
dc.contributor.authorÖztürk, Kuyas Hekimler
dc.contributor.authorYükseltürk, Aysegul
dc.contributor.authorİçduygu, Fadime Mutlu
dc.contributor.authorBaşkan, Zuhal
dc.contributor.authorBacaksız, Mehmet
dc.contributor.buuauthorŞamlı, Hale
dc.contributor.orcid0000-0003-4728-0735
dc.contributor.researcheridAAH-6488-2021
dc.contributor.scopusid6507670789
dc.date.accessioned2024-03-21T08:07:38Z
dc.date.available2024-03-21T08:07:38Z
dc.date.issued2019-01
dc.description.abstractGenetic variations in DNA repair genes may affect DNA repair capacity therefore increase risk for cancer. In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls. Genotyping of the DNA samples was carried out by multiplex PCR and matrix-assisted laser desorption/ionization mass spectrometry with time of flight measurement (MALDI-TOF) using Sequenom MassARRAY 4 analyzer. Genotype and allele distributions were calculated between the groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported. rs25487 AA genotype and A allele was found to be increased in the control group (respectively, OR 0.16 95% CI 0.02-1.06, p = 0.058; OR 1.55, 95% CI 1.01-2.36, p = 0.043) and rs861539 T allele was found to be decreased in the patient group (OR 1.53, 95% CI 1.01-2.30, p = 0.049). No association with breast cancer was found for the remaining SNPs. Our findings suggest that XRCC1 rs25487 AA genotype and A allele, XRCC3 rs861539 T allele may have protective effects in breast cancer for Turkish population.
dc.description.sponsorshipKastamonu University (KUBAP-01/2013-03)
dc.identifier.citationÖzgöz, A. vd. (2019). "Genetic variations of DNA repair genes in breast cancer". Pathology & Oncology Research, 25, 1, 107-114.
dc.identifier.doihttps://doi.org/10.1007/s12253-017-0322-3
dc.identifier.endpage114
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.issue1
dc.identifier.pubmed28983784
dc.identifier.scopus2-s2.0-85030717744
dc.identifier.startpage107
dc.identifier.urihttps://link.springer.com/article/10.1007/s12253-017-0322-3
dc.identifier.urihttps://hdl.handle.net/11452/40550
dc.identifier.volume25
dc.identifier.wos000456915500012
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFrontiers Media SA
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalPathology & Oncology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast cancer
dc.subjectDNA damage
dc.subjectDNA repair
dc.subjectPolymorphism
dc.subjectSingle-nucleotide polymorphisms
dc.subjectCell carcinoma
dc.subjectCRCC1
dc.subjectRisk
dc.subjectSusceptibility
dc.subjectAssociation
dc.subjectARG194TRP
dc.subjectRadiation
dc.subjectVariants
dc.subjectERCC2
dc.subject.scopusXeroderma pigmentosum; Base excision repair; Glycosylases
dc.subject.wosOncology
dc.subject.wosPathology
dc.titleGenetic variations of DNA repair genes in breast cancer
dc.typeArticle
dspace.entity.typePublication
local.indexed.atPubMed
local.indexed.atScopus

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